CRCGN011_HEPG2_24H:F14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 19.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN011_HEPG2_24H:F14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 5.889
TLR4 toll-like receptor 4 5.37175
CXCL2 chemokine (C-X-C motif) ligand 2 4.99
STIMATE STIM activating enhancer 4.97575
BZW2 basic leucine zipper and W2 domains 2 4.77805
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.4691
KLHL9 kelch-like family member 9 3.9588
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.87235
E2F2 E2F transcription factor 2 3.8217
GPER1 G protein-coupled estrogen receptor 1 3.81817
CYCS cytochrome c, somatic 3.5877
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.40405
WDTC1 WD and tetratricopeptide repeats 1 3.37508
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.09792
CCNF cyclin F 2.96685
SHB Src homology 2 domain containing adaptor protein B 2.7849
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.50595
EVL Enah/Vasp-like 2.4883
SOCS2 suppressor of cytokine signaling 2 2.30192
UFM1 ubiquitin-fold modifier 1 2.2868
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.2733
GPATCH8 G patch domain containing 8 2.2439
ABHD4 abhydrolase domain containing 4 2.205
LIM2 lens intrinsic membrane protein 2, 19kDa 2.1959
ALAS1 5'-aminolevulinate synthase 1 2.18605
ICAM1 intercellular adhesion molecule 1 2.12613
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.0998
ZMYM1 zinc finger, MYM-type 1 2.08375
CLEC1A C-type lectin domain family 1, member A 2.0612
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.0388
SETD1A SET domain containing 1A 2.0313
ELF2 E74-like factor 2 (ets domain transcription factor) 2.0246

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -5.6292
PCNA proliferating cell nuclear antigen -5.1007
ZNF586 zinc finger protein 586 -4.92735
GNAS GNAS complex locus -3.65747
CCNB2 cyclin B2 -3.08655
OXA1L oxidase (cytochrome c) assembly 1-like -2.563
RBM34 RNA binding motif protein 34 -2.39127
SNX11 sorting nexin 11 -2.3888
TXNRD1 thioredoxin reductase 1 -2.37885
CSNK1E casein kinase 1, epsilon -2.3453
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.27896
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1567
PFKP phosphofructokinase, platelet -2.11765
SDF2L1 stromal cell-derived factor 2-like 1 -2.07355
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.0628
LAP3 leucine aminopeptidase 3 -2.0372