| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 9.7 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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57 genes differentially expressed following the CRCGN011_HEPG2_24H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STIMATE | STIM activating enhancer | 5.52055 |
| MSRA | methionine sulfoxide reductase A | 5.21455 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.8408 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 4.33483 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 4.01485 |
| HSPA1A | heat shock 70kDa protein 1A | 3.8765 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 3.76105 |
| TLR4 | toll-like receptor 4 | 3.572 |
| STXBP1 | syntaxin binding protein 1 | 3.3929 |
| KLHL9 | kelch-like family member 9 | 3.3887 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 3.36505 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.28105 |
| SOCS2 | suppressor of cytokine signaling 2 | 3.25025 |
| TESK1 | testis-specific kinase 1 | 3.1838 |
| RNF167 | ring finger protein 167 | 3.05915 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.94765 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 2.90768 |
| NMU | neuromedin U | 2.84585 |
| ZNF589 | zinc finger protein 589 | 2.82492 |
| TRIM13 | tripartite motif containing 13 | 2.8118 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.7145 |
| RAB21 | RAB21, member RAS oncogene family | 2.65405 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 2.6179 |
| SATB1 | SATB homeobox 1 | 2.5071 |
| TBXA2R | thromboxane A2 receptor | 2.43991 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | 2.3641 |
| SCRN1 | secernin 1 | 2.36385 |
| TRIB3 | tribbles pseudokinase 3 | 2.2891 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.2871 |
| NGRN | neugrin, neurite outgrowth associated | 2.1964 |
| KAT6A | K(lysine) acetyltransferase 6A | 2.1823 |
| LGALSL | lectin, galactoside-binding-like | 2.10515 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 2.08265 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -5.512 |
| CCDC86 | coiled-coil domain containing 86 | -5.50735 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -5.36725 |
| TUBB6 | tubulin, beta 6 class V | -5.2715 |
| LDHD | lactate dehydrogenase D | -5.03885 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.7387 |
| GDF15 | growth differentiation factor 15 | -4.44945 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.36935 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -4.1549 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.8554 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.5565 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -3.5104 |
| GNAS | GNAS complex locus | -3.46711 |
| PCNA | proliferating cell nuclear antigen | -3.35455 |
| HMG20B | high mobility group 20B | -3.2686 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -3.25075 |
| C5 | complement component 5 | -3.2467 |
| HEATR1 | HEAT repeat containing 1 | -3.04822 |
| CCNB2 | cyclin B2 | -3.00735 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -2.56646 |
| RGS1 | regulator of G-protein signaling 1 | -2.5007 |
| RAD51C | RAD51 paralog C | -2.2624 |
| GTF2B | general transcription factor IIB | -2.04145 |
| KRT17 | keratin 17, type I | -2.0056 |
