CRCGN011_HEPG2_24H:F16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 4.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN011_HEPG2_24H:F16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 9.03183
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.89615
CYCS cytochrome c, somatic 5.8455
PLS1 plastin 1 5.14765
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.9957
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.75365
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.63005
PRKCH protein kinase C, eta 4.60943
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.4824
EPN2 epsin 2 4.40075
E2F2 E2F transcription factor 2 4.0639
C2CD2 C2 calcium-dependent domain containing 2 3.9947
SSBP2 single-stranded DNA binding protein 2 3.85195
GPER1 G protein-coupled estrogen receptor 1 3.45785
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.9757
JADE2 jade family PHD finger 2 2.85358
ITFG1 integrin alpha FG-GAP repeat containing 1 2.8468
SOCS2 suppressor of cytokine signaling 2 2.54262
TRIM13 tripartite motif containing 13 2.4896
NMU neuromedin U 2.4803
MAGEA6 melanoma antigen family A6 2.37657
KRT4 keratin 4, type II 2.30585
RFTN1 raftlin, lipid raft linker 1 2.2688
CEMIP2 cell migration inducing hyaluronidase 2 2.2501
TMPRSS3 transmembrane protease, serine 3 2.2093
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.17555
EVL Enah/Vasp-like 2.1541
COQ9 coenzyme Q9 2.1356
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.09505
TGFB3 transforming growth factor, beta 3 2.0885
GIN1 gypsy retrotransposon integrase 1 2.0791
HLA-DRA major histocompatibility complex, class II, DR alpha 2.05805
UBQLN2 ubiquilin 2 2.0542
SGCE sarcoglycan, epsilon 2.05345
RAB5IF RAB5 interacting factor 2.0519
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.05015

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.50085
KDM3A lysine (K)-specific demethylase 3A -5.27615
UGDH UDP-glucose 6-dehydrogenase -5.1166
CDC20 cell division cycle 20 -4.66275
MAP7 microtubule-associated protein 7 -4.43488
MACF1 microtubule-actin crosslinking factor 1 -3.88652
NRIP1 nuclear receptor interacting protein 1 -3.36328
GDF15 growth differentiation factor 15 -3.2475
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.146
CCNB2 cyclin B2 -2.62695
ITGAV integrin, alpha V -2.57405
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.35085
IFNGR1 interferon gamma receptor 1 -2.34933
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.29125
NADSYN1 NAD synthetase 1 -2.24105
MORC3 MORC family CW-type zinc finger 3 -2.1096
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.10628
ADAM28 ADAM metallopeptidase domain 28 -2.10308
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.09835
MAGED2 melanoma antigen family D2 -2.08117
LEFTY1 left-right determination factor 1 -2.06195
SOWAHC sosondowah ankyrin repeat domain family member C -2.05875
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.0257
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.0171