CRCGN011_HEPG2_24H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 2.43 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

122 genes differentially expressed following the CRCGN011_HEPG2_24H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 6.27515
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.71915
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.1999
NOTCH1 notch 1 4.9825
UBQLN2 ubiquilin 2 4.97985
CARMIL1 capping protein regulator and myosin 1 linker 1 4.92325
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.91027
STIMATE STIM activating enhancer 4.9034
CHMP6 charged multivesicular body protein 6 4.759
SNAP25 synaptosomal-associated protein, 25kDa 4.64445
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.50335
STK10 serine/threonine kinase 10 4.49083
ADRB2 adrenoceptor beta 2, surface 4.48525
RAB21 RAB21, member RAS oncogene family 4.10855
KDM5A lysine (K)-specific demethylase 5A 3.8717
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.7733
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.76143
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.69545
MAP7 microtubule-associated protein 7 3.56652
PRR15L proline rich 15-like 3.51055
ABHD4 abhydrolase domain containing 4 3.4661
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.3714
CCNE2 cyclin E2 3.14353
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.9149
FZD7 frizzled class receptor 7 2.75312
TBXA2R thromboxane A2 receptor 2.7338
GPATCH8 G patch domain containing 8 2.67438
CELA3B chymotrypsin-like elastase family, member 3B 2.58625
CTRB2 chymotrypsinogen B2 2.5746
DAPL1 death associated protein-like 1 2.5514
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.53897
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.51292
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.4782
GRB10 growth factor receptor-bound protein 10 2.43318
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.42455
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 2.41755
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.40885
TESC tescalcin 2.38095
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.3763
WASF3 WAS protein family, member 3 2.3542
MANBA mannosidase, beta A, lysosomal 2.3144
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.3034
GAL3ST4 galactose-3-O-sulfotransferase 4 2.3012
CELA3A chymotrypsin-like elastase family, member 3A 2.29635
MTA2 metastasis associated 1 family, member 2 2.28215
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 2.27915
TESK1 testis-specific kinase 1 2.2481
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.23162
RARG retinoic acid receptor, gamma 2.2201
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.20535
LCN2 lipocalin 2 2.20425
TMEM109 transmembrane protein 109 2.1898
REG3A regenerating islet-derived 3 alpha 2.18945
HYDIN HYDIN, axonemal central pair apparatus protein 2.18915
CD40 CD40 molecule, TNF receptor superfamily member 5 2.183
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.1761
EFR3B EFR3 homolog B (S. cerevisiae) 2.1713
WDTC1 WD and tetratricopeptide repeats 1 2.15505
BMP4 bone morphogenetic protein 4 2.14955
TPSG1 tryptase gamma 1 2.14285
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 2.12017
CLPS colipase, pancreatic 2.08485
SLC22A14 solute carrier family 22, member 14 2.082
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.08145
LMOD1 leiomodin 1 (smooth muscle) 2.07915
HOXA4 homeobox A4 2.0531
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.0448
COQ6 coenzyme Q6 monooxygenase 2.0425
ADGRE5 adhesion G protein-coupled receptor E5 2.0395
TCTN2 tectonic family member 2 2.03325
CTRC chymotrypsin C (caldecrin) 2.0278
AMHR2 anti-Mullerian hormone receptor, type II 2.0249
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.02265
NTSR2 neurotensin receptor 2 2.0038
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.00282

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.9525
CCNB1 cyclin B1 -5.4962
LAP3 leucine aminopeptidase 3 -5.4423
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.86735
NT5DC2 5'-nucleotidase domain containing 2 -4.78795
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.5925
MRPS2 mitochondrial ribosomal protein S2 -4.507
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.42985
CDC20 cell division cycle 20 -4.2518
TLCD3A TLC domain containing 3A -4.2404
FGFR4 fibroblast growth factor receptor 4 -3.93508
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.68875
WASHC4 WASH complex subunit 4 -3.65055
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.6087
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.5334
PCNA proliferating cell nuclear antigen -3.18195
MAPK13 mitogen-activated protein kinase 13 -3.12018
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.94975
GADD45A growth arrest and DNA-damage-inducible, alpha -2.78795
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.77695
MTFR1 mitochondrial fission regulator 1 -2.76883
HEATR1 HEAT repeat containing 1 -2.70325
OXA1L oxidase (cytochrome c) assembly 1-like -2.68485
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.49452
SOAT2 sterol O-acyltransferase 2 -2.48025
ARL5A ADP-ribosylation factor-like 5A -2.4603
JPT1 Jupiter microtubule associated homolog 1 -2.4409
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.41297
TPST1 tyrosylprotein sulfotransferase 1 -2.3697
RNF167 ring finger protein 167 -2.3523
SCAND1 SCAN domain containing 1 -2.314
NCKAP1 NCK-associated protein 1 -2.30865
KLHDC2 kelch domain containing 2 -2.2888
CKM creatine kinase, muscle -2.24995
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.1828
ARHGAP9 Rho GTPase activating protein 9 -2.1375
TNNT3 troponin T type 3 (skeletal, fast) -2.1286
LIMA1 LIM domain and actin binding 1 -2.09235
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.0909
MYL1 myosin, light chain 1, alkali; skeletal, fast -2.08465
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -2.07525
FAT4 FAT atypical cadherin 4 -2.0656
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -2.0523
DOLK dolichol kinase -2.04915
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.04435
CDC25B cell division cycle 25B -2.01635
MYL2 myosin, light chain 2, regulatory, cardiac, slow -2.0118