CRCGN011_HEPG2_24H:F18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description xylene mixture (60% m-xylene, 9% o-xylene, 14% p-xylene, 17% ethylbenzene) 1.21 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN011_HEPG2_24H:F18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.64485
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.06332
ATP11B ATPase, class VI, type 11B 4.9819
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.79735
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.7694
PHKG2 phosphorylase kinase, gamma 2 (testis) 4.63715
CIAO3 cytosolic iron-sulfur assembly component 3 4.47185
STIMATE STIM activating enhancer 4.1725
AMDHD2 amidohydrolase domain containing 2 4.02915
MICALL1 MICAL-like 1 3.94273
EVL Enah/Vasp-like 3.859
HOXA10 homeobox A10 3.79195
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.7616
MTERF3 mitochondrial transcription termination factor 3 3.52315
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 3.36745
JADE2 jade family PHD finger 2 3.35803
RNF167 ring finger protein 167 3.0339
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.91795
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.8328
LOC122526780 uncharacterized LOC122526780 2.6531
CCNF cyclin F 2.55708
GADD45A growth arrest and DNA-damage-inducible, alpha 2.50275
CLDN1 claudin 1 2.4674
WDR7 WD repeat domain 7 2.3829
FUBP3 far upstream element (FUSE) binding protein 3 2.3357
YJU2B YJU2 splicing factor homolog B 2.3321
HDAC2 histone deacetylase 2 2.3209
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.30078
TARBP2 TAR (HIV-1) RNA binding protein 2 2.2758
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.2433
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.22755
SOCS1 suppressor of cytokine signaling 1 2.20822
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.19198
INTS11 integrator complex subunit 11 2.16935
DDTL D-dopachrome tautomerase-like 2.14855
KRT16 keratin 16, type I 2.1212
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.0929
CEP57 centrosomal protein 57kDa 2.08882
NFE2L3 nuclear factor, erythroid 2-like 3 2.07065
ARMCX5 armadillo repeat containing, X-linked 5 2.03595
DBR1 debranching RNA lariats 1 2.03505
CDC23 cell division cycle 23 2.02795

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.32449
CCNB2 cyclin B2 -7.08505
CDC20 cell division cycle 20 -5.31545
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.04325
CCDC86 coiled-coil domain containing 86 -4.94255
ZDHHC6 zinc finger, DHHC-type containing 6 -4.78535
LDHD lactate dehydrogenase D -4.5113
VAT1 vesicle amine transport 1 -4.3962
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.33745
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.78285
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.624
MAPK13 mitogen-activated protein kinase 13 -3.58435
GRWD1 glutamate-rich WD repeat containing 1 -3.54055
EIF5 eukaryotic translation initiation factor 5 -3.5234
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -2.89245
PEG10 paternally expressed 10 -2.73067
CHRDL1 chordin-like 1 -2.64375
CYTIP cytohesin 1 interacting protein -2.557
SCG3 secretogranin III -2.5469
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.5403
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.51117
DOCK3 dedicator of cytokinesis 3 -2.5083
ADIPOQ adiponectin, C1Q and collagen domain containing -2.4881
ZC4H2 zinc finger, C4H2 domain containing -2.46725
OMD osteomodulin -2.46567
EGFL6 EGF-like-domain, multiple 6 -2.46205
DSG2 desmoglein 2 -2.3616
FTO fat mass and obesity associated -2.36045
HSF2BP heat shock transcription factor 2 binding protein -2.2942
CDH10 cadherin 10, type 2 (T2-cadherin) -2.28135
SKIL SKI-like proto-oncogene -2.27965
TCEAL2 transcription elongation factor A (SII)-like 2 -2.26535
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -2.265
NRIP1 nuclear receptor interacting protein 1 -2.25085
PLIN2 perilipin 2 -2.23815
ZFAND5 zinc finger, AN1-type domain 5 -2.20718
ZNF286A zinc finger protein 286A -2.19445
ZNF394 zinc finger protein 394 -2.18935
JAM2 junctional adhesion molecule 2 -2.17875
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.1707
KCNK3 potassium channel, two pore domain subfamily K, member 3 -2.16585
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -2.15025
PINK1 PTEN induced putative kinase 1 -2.1464
TMT1A thiol methyltransferase 1A -2.1298
YIPF3 Yip1 domain family, member 3 -2.1218
ZNF165 zinc finger protein 165 -2.1198
SESN1 sestrin 1 -2.10075
PIEZO2 piezo-type mechanosensitive ion channel component 2 -2.0989
AOC3 amine oxidase, copper containing 3 -2.08805
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.0843
MCOLN3 mucolipin 3 -2.0738
YBX1 Y box binding protein 1 -2.0604
RND2 Rho family GTPase 2 -2.05982
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -2.0492
TENT5C terminal nucleotidyltransferase 5C -2.0462
FOXF2 forkhead box F2 -2.04575
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.0409
CPA4 carboxypeptidase A4 -2.03615
SH3GL2 SH3-domain GRB2-like 2 -2.01855
ELMO1 engulfment and cell motility 1 -2.01215
LMO3 LIM domain only 3 (rhombotin-like 2) -2.002