CRCGN011_HEPG2_24H:F19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description prednisolone 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN011_HEPG2_24H:F19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
TESK1 testis-specific kinase 1 5.9366
PHKG2 phosphorylase kinase, gamma 2 (testis) 5.1741
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.052
PPARG peroxisome proliferator-activated receptor gamma 5.0059
STIMATE STIM activating enhancer 4.71755
ADRB2 adrenoceptor beta 2, surface 4.7057
PEX11A peroxisomal biogenesis factor 11 alpha 4.60357
KLHL9 kelch-like family member 9 4.54432
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.3962
TLR4 toll-like receptor 4 4.27885
PLS1 plastin 1 4.1002
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.91512
SLC75A1 solute carrier family 75 member 1 3.8097
COL11A1 collagen, type XI, alpha 1 3.43542
CYCS cytochrome c, somatic 3.24045
GPER1 G protein-coupled estrogen receptor 1 3.13443
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.03475
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.01267
GPATCH8 G patch domain containing 8 2.86028
SMIM40 small integral membrane protein 40 2.7688
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.5905
TNIP2 TNFAIP3 interacting protein 2 2.58542
SSBP2 single-stranded DNA binding protein 2 2.57852
DDIT4 DNA-damage-inducible transcript 4 2.57295
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.527
ZNF589 zinc finger protein 589 2.52687
TREM1 triggering receptor expressed on myeloid cells 1 2.4822
CCL4 chemokine (C-C motif) ligand 4 2.4412
UBAP1 ubiquitin associated protein 1 2.41355
CD40 CD40 molecule, TNF receptor superfamily member 5 2.32853
GORASP1 golgi reassembly stacking protein 1, 65kDa 2.3232
WDR7 WD repeat domain 7 2.2889
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.28075
CREB3L4 cAMP responsive element binding protein 3-like 4 2.27565
CDC45 cell division cycle 45 2.2281
EXOSC4 exosome component 4 2.0686
TNF tumor necrosis factor 2.0535
PDE8B phosphodiesterase 8B 2.0409
INSIG2 insulin induced gene 2 2.0289
LTA lymphotoxin alpha 2.017
GATA2 GATA binding protein 2 2.01205
SIAH2 siah E3 ubiquitin protein ligase 2 2.00935

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -9.15485
LDHD lactate dehydrogenase D -5.85915
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.69785
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.4439
HEATR1 HEAT repeat containing 1 -5.0992
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.06675
GDF15 growth differentiation factor 15 -4.7951
PLK1 polo-like kinase 1 -4.75625
NGRN neugrin, neurite outgrowth associated -4.66635
UBE3C ubiquitin protein ligase E3C -4.59955
ARID5B AT rich interactive domain 5B (MRF1-like) -4.27525
MAPK13 mitogen-activated protein kinase 13 -2.85302
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.81265
PRPF4 pre-mRNA processing factor 4 -2.76708
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.7636
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.73282
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.63565
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.59585
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.50535
NDFIP1 Nedd4 family interacting protein 1 -2.3014
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.2907
NAXD NAD(P)HX dehydratase -2.27555
METTL16 methyltransferase like 16 -2.11155
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.0693
HLA-DMA major histocompatibility complex, class II, DM alpha -2.0667
CCNH cyclin H -2.04885
NVL nuclear VCP-like -2.0189
LAP3 leucine aminopeptidase 3 -2.00375