CRCGN011_HEPG2_24H:F20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description prednisolone 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN011_HEPG2_24H:F20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.5246
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.30005
STIMATE STIM activating enhancer 5.27675
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.26825
RPP38 ribonuclease P/MRP 38kDa subunit 5.1903
MNAT1 MNAT CDK-activating kinase assembly factor 1 5.16705
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.00965
PEX11A peroxisomal biogenesis factor 11 alpha 4.6999
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.5171
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.4541
PPARG peroxisome proliferator-activated receptor gamma 4.32665
ATP11B ATPase, class VI, type 11B 4.17255
CCL2 chemokine (C-C motif) ligand 2 3.8663
VAV3 vav 3 guanine nucleotide exchange factor 3.78543
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.75145
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.7242
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.53408
CYCS cytochrome c, somatic 3.50085
PRKCH protein kinase C, eta 3.35468
EXOSC4 exosome component 4 3.26195
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.07753
WDTC1 WD and tetratricopeptide repeats 1 3.04493
DDIT4 DNA-damage-inducible transcript 4 3.02875
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.6784
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.6739
PEX3 peroxisomal biogenesis factor 3 2.66815
LSR lipolysis stimulated lipoprotein receptor 2.60665
SHB Src homology 2 domain containing adaptor protein B 2.58032
TMOD1 tropomodulin 1 2.5542
CMTR1 cap methyltransferase 1 2.5383
HMOX1 heme oxygenase 1 2.513
EVL Enah/Vasp-like 2.47305
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.46515
FASTKD5 FAST kinase domains 5 2.4566
IFI6 interferon, alpha-inducible protein 6 2.41575
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.37365
NLRP2B NLR family pyrin domain containing 2B 2.37175
OSBPL9 oxysterol binding protein-like 9 2.2983
DCAF6 DDB1 and CUL4 associated factor 6 2.2121
AFG3L2 AFG3-like AAA ATPase 2 2.1949
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 2.1581
UQCRC1 ubiquinol-cytochrome c reductase core protein I 2.1562
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.15425
DIPK1A divergent protein kinase domain 1A 2.14815
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.13035
RAB23 RAB23, member RAS oncogene family 2.1219
ISG15 ISG15 ubiquitin-like modifier 2.10245
USP18 ubiquitin specific peptidase 18 2.09635
RNF123 ring finger protein 123 2.08765
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 2.0827
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.07635
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.075
BAG2 BCL2-associated athanogene 2 2.06525
COL11A1 collagen, type XI, alpha 1 2.06308
MB myoglobin 2.0482
SIX1 SIX homeobox 1 2.04515
PYGM phosphorylase, glycogen, muscle 2.0336
CCDC170 coiled-coil domain containing 170 2.0294
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.02935
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.02743
MECR mitochondrial trans-2-enoyl-CoA reductase 2.0226
GAMT guanidinoacetate N-methyltransferase 2.01355
GOLT1A golgi transport 1A 2.01185
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.0067
DRC3 dynein regulatory complex subunit 3 2.0022

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.3062
CCNB2 cyclin B2 -7.53415
TMEM109 transmembrane protein 109 -5.5957
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.35415
THAP11 THAP domain containing 11 -4.73425
PCCB propionyl CoA carboxylase, beta polypeptide -4.66275
GTPBP8 GTP-binding protein 8 (putative) -4.4507
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.332
ADI1 acireductone dioxygenase 1 -4.0903
CHMP4B charged multivesicular body protein 4B -4.03067
FGFR4 fibroblast growth factor receptor 4 -3.95715
GNAS GNAS complex locus -3.52701
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.46545
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.05998
TBC1D31 TBC1 domain family, member 31 -2.91825
YME1L1 YME1-like 1 ATPase -2.73922
ZHX2 zinc fingers and homeoboxes 2 -2.2734
CDC25B cell division cycle 25B -2.267
EIF5 eukaryotic translation initiation factor 5 -2.25786
CDHR2 cadherin-related family member 2 -2.22
SLC35F2 solute carrier family 35, member F2 -2.19925
FOS FBJ murine osteosarcoma viral oncogene homolog -2.153
BMAL1 basic helix-loop-helix ARNT like 1 -2.11452
IGSF6 immunoglobulin superfamily, member 6 -2.1141
KCNIP1 Kv channel interacting protein 1 -2.1051
MARCHF1 membrane associated ring-CH-type finger 1 -2.10445
CARD9 caspase recruitment domain family, member 9 -2.0946
FMNL1 formin-like 1 -2.08785
FOXE1 forkhead box E1 -2.0752
KCNK3 potassium channel, two pore domain subfamily K, member 3 -2.07225
PGM1 phosphoglucomutase 1 -2.06315
NRIP1 nuclear receptor interacting protein 1 -2.04825
TBXAS1 thromboxane A synthase 1 (platelet) -2.0445
RPL10A ribosomal protein L10a -2.03985
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 -2.02935
OXA1L oxidase (cytochrome c) assembly 1-like -2.0242
RIN2 Ras and Rab interactor 2 -2.02375
IGSF1 immunoglobulin superfamily, member 1 -2.01335
MYZAP myocardial zonula adherens protein -2.0101
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.00938
CCDC90B coiled-coil domain containing 90B -2.0088