CRCGN011_HEPG2_24H:F22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description prednisolone 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN011_HEPG2_24H:F22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
MNAT1 MNAT CDK-activating kinase assembly factor 1 5.2616
CHMP6 charged multivesicular body protein 6 5.1817
MYLK myosin light chain kinase 5.17205
LCN2 lipocalin 2 5.0
CXCL2 chemokine (C-X-C motif) ligand 2 4.95315
E2F2 E2F transcription factor 2 4.86675
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.80785
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.5439
HOXA10 homeobox A10 4.1306
GPER1 G protein-coupled estrogen receptor 1 3.46865
ABHD6 abhydrolase domain containing 6 3.44972
KLHL9 kelch-like family member 9 3.34212
PRR15L proline rich 15-like 3.10805
DYNLT3 dynein, light chain, Tctex-type 3 2.9976
TIAM1 T-cell lymphoma invasion and metastasis 1 2.94458
RXYLT1 ribitol xylosyltransferase 1 2.92428
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.8467
H2BC21 H2B clustered histone 21 2.7521
JADE2 jade family PHD finger 2 2.70187
COQ8A coenzyme Q8A 2.65525
ADAT1 adenosine deaminase, tRNA-specific 1 2.51675
CHN1 chimerin 1 2.42605
CCNA1 cyclin A1 2.41295
ZNF232 zinc finger protein 232 2.33585
TUBA3E tubulin, alpha 3e 2.3095
HLA-DRA major histocompatibility complex, class II, DR alpha 2.27288
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 2.27035
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.26783
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.25275
NMU neuromedin U 2.24955
ANO1 anoctamin 1, calcium activated chloride channel 2.23255
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.22635
CYB561 cytochrome b561 2.18725
VAC14 Vac14 homolog (S. cerevisiae) 2.17515
PFN2 profilin 2 2.16595
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.16083
FCHO1 FCH domain only 1 2.14295
MAGEA6 melanoma antigen family A6 2.14293
CCNF cyclin F 2.13385
BPHL biphenyl hydrolase-like (serine hydrolase) 2.13135
MEST mesoderm specific transcript 2.0731
SMIM10L1 small integral membrane protein 10 like 1 2.05405
DDIT4 DNA-damage-inducible transcript 4 2.009
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.0004

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -10.0
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -7.6056
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.39595
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.05175
ADI1 acireductone dioxygenase 1 -5.0294
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.97045
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.9417
KDM3A lysine (K)-specific demethylase 3A -4.70655
HSPB1 heat shock 27kDa protein 1 -4.5722
TRIB3 tribbles pseudokinase 3 -4.30405
CHMP4B charged multivesicular body protein 4B -4.21058
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.18255
NGRN neugrin, neurite outgrowth associated -3.88955
CD320 CD320 molecule -3.73745
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.55
PCNA proliferating cell nuclear antigen -3.534
YME1L1 YME1-like 1 ATPase -3.47667
PAEP progestagen-associated endometrial protein -2.93905
MAPK13 mitogen-activated protein kinase 13 -2.73917
PDZD2 PDZ domain containing 2 -2.63855
ACLY ATP citrate lyase -2.55297
RABL6 RAB, member RAS oncogene family-like 6 -2.38435
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.3668
ITGB1BP1 integrin beta 1 binding protein 1 -2.25227
IFRD1 interferon-related developmental regulator 1 -2.22945
RNF103-CHMP3 RNF103-CHMP3 readthrough -2.2149
STXBP1 syntaxin binding protein 1 -2.05775
ACTL6A actin-like 6A -2.0445
HLA-DMA major histocompatibility complex, class II, DM alpha -2.02905
EIF5 eukaryotic translation initiation factor 5 -2.02844
RGS20 regulator of G-protein signaling 20 -2.0048