CRCGN011_HEPG2_24H:F23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description prednisolone 2.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN011_HEPG2_24H:F23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 5.4413
MAMLD1 mastermind-like domain containing 1 5.40655
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.2848
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.76485
PLS1 plastin 1 4.0218
CCL2 chemokine (C-C motif) ligand 2 3.91545
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.59635
RAB21 RAB21, member RAS oncogene family 3.28995
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.0201
DYNLT3 dynein, light chain, Tctex-type 3 2.997
COL11A1 collagen, type XI, alpha 1 2.9075
VAV3 vav 3 guanine nucleotide exchange factor 2.89935
TBK1 TANK-binding kinase 1 2.87765
CLDN1 claudin 1 2.75125
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.7421
DDIT4 DNA-damage-inducible transcript 4 2.66055
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.46892
ANKRD46 ankyrin repeat domain 46 2.4418
CCNF cyclin F 2.43703
DIPK1A divergent protein kinase domain 1A 2.38158
GPATCH8 G patch domain containing 8 2.33227
HAGH hydroxyacylglutathione hydrolase 2.2969
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 2.14915
MAGEA6 melanoma antigen family A6 2.146
CLOCK clock circadian regulator 2.1318
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.12815
SMAD3 SMAD family member 3 2.11687
CHN1 chimerin 1 2.0916
GPX3 glutathione peroxidase 3 2.07443
GSTZ1 glutathione S-transferase zeta 1 2.0281

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.70895
CCNB1 cyclin B1 -5.89215
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.4295
NT5DC2 5'-nucleotidase domain containing 2 -5.1593
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.1403
SLC35F2 solute carrier family 35, member F2 -5.00125
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7725
LDHD lactate dehydrogenase D -4.6751
CDC20 cell division cycle 20 -4.66275
MRPS2 mitochondrial ribosomal protein S2 -4.58575
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.48475
PCCB propionyl CoA carboxylase, beta polypeptide -4.31325
PCNA proliferating cell nuclear antigen -4.2251
SCAND1 SCAN domain containing 1 -3.90125
OXA1L oxidase (cytochrome c) assembly 1-like -3.46445
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.42285
TLCD3A TLC domain containing 3A -3.3858
HEATR1 HEAT repeat containing 1 -3.18425
GDF15 growth differentiation factor 15 -2.9214
WDR62 WD repeat domain 62 -2.9008
HLA-DMA major histocompatibility complex, class II, DM alpha -2.8096
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.68211
LCN1 lipocalin 1 -2.625
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.4616
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough -2.4557
VASP vasodilator-stimulated phosphoprotein -2.4253
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.38578
ERBIN erbb2 interacting protein -2.38395
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.31065
ANPEP alanyl (membrane) aminopeptidase -2.30965
MILR1 mast cell immunoglobulin-like receptor 1 -2.2634
PTGDR prostaglandin D2 receptor (DP) -2.256
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.2405
GYPC glycophorin C (Gerbich blood group) -2.2329
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.1568
TRIM6-TRIM34 TRIM6-TRIM34 readthrough -2.0935
CCNH cyclin H -2.0338
EIF5 eukaryotic translation initiation factor 5 -2.01374
RTP4 receptor (chemosensory) transporter protein 4 -2.00815
PELI1 pellino E3 ubiquitin protein ligase 1 -2.00335