CRCGN011_HEPG2_24H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description prednisolone 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN011_HEPG2_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 8.42785
NOTCH1 notch 1 5.8676
C2CD2 C2 calcium-dependent domain containing 2 5.35145
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.17335
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.90555
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.844
PPARG peroxisome proliferator-activated receptor gamma 4.814
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.37015
CCL2 chemokine (C-C motif) ligand 2 4.2979
GPER1 G protein-coupled estrogen receptor 1 3.96515
ABHD6 abhydrolase domain containing 6 3.88747
TLR4 toll-like receptor 4 3.44345
SNAP25 synaptosomal-associated protein, 25kDa 3.16525
NMU neuromedin U 2.92595
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.9126
ADGRE5 adhesion G protein-coupled receptor E5 2.8472
TREM1 triggering receptor expressed on myeloid cells 1 2.73
PLSCR3 phospholipid scramblase 3 2.52343
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.43805
ZNF589 zinc finger protein 589 2.4091
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.39697
ELP3 elongator acetyltransferase complex subunit 3 2.39145
PRMT7 protein arginine methyltransferase 7 2.35415
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.3364
CTSH cathepsin H 2.29355
RESF1 retroelement silencing factor 1 2.2868
TRIM13 tripartite motif containing 13 2.2631
CYCS cytochrome c, somatic 2.21445
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.19855
KLHL9 kelch-like family member 9 2.19155
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 2.13945
USP20 ubiquitin specific peptidase 20 2.1387
NPTXR neuronal pentraxin receptor 2.1345
COL11A1 collagen, type XI, alpha 1 2.08398
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.0664
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.06455
JADE2 jade family PHD finger 2 2.05772
DOLK dolichol kinase 2.0522
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.0472
LSM1 LSM1, U6 small nuclear RNA associated 2.04625
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.00975
CCDC51 coiled-coil domain containing 51 2.0065

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -10.0
DSG2 desmoglein 2 -7.6177
GNAS GNAS complex locus -7.50081
MAPK13 mitogen-activated protein kinase 13 -5.39792
LDHD lactate dehydrogenase D -5.39615
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.18105
UGDH UDP-glucose 6-dehydrogenase -5.0745
GDF15 growth differentiation factor 15 -5.0
PCNA proliferating cell nuclear antigen -4.7455
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.539
TRIB3 tribbles pseudokinase 3 -4.52715
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.48945
MAP7 microtubule-associated protein 7 -4.47223
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.11855
MRPS2 mitochondrial ribosomal protein S2 -4.02675
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.61143
HMG20B high mobility group 20B -3.4652
RBM42 RNA binding motif protein 42 -3.35215
CAPNS1 calpain, small subunit 1 -3.24565
ADI1 acireductone dioxygenase 1 -3.1901
TLCD3A TLC domain containing 3A -3.16655
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.09472
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.09425
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.9485
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.8745
TCHH trichohyalin -2.87165
STAT1 signal transducer and activator of transcription 1, 91kDa -2.75186
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.67435
TBCB tubulin folding cofactor B -2.61255
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.56533
RPP40 ribonuclease P/MRP 40kDa subunit -2.55955
HLA-DMA major histocompatibility complex, class II, DM alpha -2.5425
HEATR1 HEAT repeat containing 1 -2.4504
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.4292
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -2.38888
DERA deoxyribose-phosphate aldolase (putative) -2.36195
TUBB2B tubulin, beta 2B class IIb -2.2572
TMEM147 transmembrane protein 147 -2.2507
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.2224
PA2G4 proliferation-associated 2G4, 38kDa -2.18243
KRT34 keratin 34, type I -2.17745
COL4A4 collagen, type IV, alpha 4 -2.17715
RUBCNL rubicon like autophagy enhancer -2.1704
CSNK2B casein kinase 2, beta polypeptide -2.1696
MUC7 mucin 7, secreted -2.16415
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.16165
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.15875
PCDHB16 protocadherin beta 16 -2.1423
QPCT glutaminyl-peptide cyclotransferase -2.0891
SCMH1 sex comb on midleg homolog 1 (Drosophila) -2.085
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.07855
PGM1 phosphoglucomutase 1 -2.07655
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -2.07305
RGS2 regulator of G-protein signaling 2 -2.05275
WDR11 WD repeat domain 11 -2.05035
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.0445
NELFA negative elongation factor complex member A -2.04373
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -2.0357
SIM1 single-minded family bHLH transcription factor 1 -2.03425
KDM4D lysine (K)-specific demethylase 4D -2.0263
CHPT1 choline phosphotransferase 1 -2.00025