CRCGN011_HEPG2_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triphenyl phosphate 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

203 genes differentially expressed following the CRCGN011_HEPG2_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDC45 cell division cycle 45 6.1143
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.54835
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0548
LCN2 lipocalin 2 5.0
TRIB3 tribbles pseudokinase 3 4.64525
UBQLN2 ubiquilin 2 4.6021
MEF2C myocyte enhancer factor 2C 4.51855
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.3428
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.34135
GSTZ1 glutathione S-transferase zeta 1 4.24075
GLRX glutaredoxin (thioltransferase) 4.23732
BACE2 beta-site APP-cleaving enzyme 2 4.21245
MAP7 microtubule-associated protein 7 4.1171
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.11705
CXCL2 chemokine (C-X-C motif) ligand 2 4.09365
CDPF1 cysteine-rich, DPF motif domain containing 1 4.03905
TXNRD1 thioredoxin reductase 1 4.01505
INPP1 inositol polyphosphate-1-phosphatase 3.9588
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.95735
RALB v-ral simian leukemia viral oncogene homolog B 3.94035
NOSIP nitric oxide synthase interacting protein 3.906
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.5121
LSR lipolysis stimulated lipoprotein receptor 3.4431
CCL2 chemokine (C-C motif) ligand 2 3.3266
COL11A1 collagen, type XI, alpha 1 3.29235
AARS1 alanyl-tRNA synthetase 1 3.2634
SQSTM1 sequestosome 1 3.22825
PEX11A peroxisomal biogenesis factor 11 alpha 3.1253
FASTKD5 FAST kinase domains 5 3.10475
VAT1 vesicle amine transport 1 2.9783
RBM15B RNA binding motif protein 15B 2.80995
GPER1 G protein-coupled estrogen receptor 1 2.79542
MTERF3 mitochondrial transcription termination factor 3 2.78215
GRB10 growth factor receptor-bound protein 10 2.78032
CTSH cathepsin H 2.7645
SATB1 SATB homeobox 1 2.74815
UGT8 UDP glycosyltransferase 8 2.69705
GPATCH8 G patch domain containing 8 2.69415
MVP major vault protein 2.69205
TFEB transcription factor EB 2.6452
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.633
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.62645
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.6119
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.60765
ALDOC aldolase C, fructose-bisphosphate 2.5334
ABHD4 abhydrolase domain containing 4 2.533
SERINC1 serine incorporator 1 2.50875
SHTN1 shootin 1 2.4907
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.4812
CIDEB cell death-inducing DFFA-like effector b 2.46565
APOD apolipoprotein D 2.4432
GATA2 GATA binding protein 2 2.4354
SLC25A46 solute carrier family 25, member 46 2.43325
SKIC3 SKI3 subunit of superkiller complex 2.42395
OGDHL oxoglutarate dehydrogenase-like 2.4191
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.4072
NNT nicotinamide nucleotide transhydrogenase 2.3942
C4BPB complement component 4 binding protein, beta 2.38725
ADGRG6 adhesion G protein-coupled receptor G6 2.3599
MCF2L MCF.2 cell line derived transforming sequence-like 2.35255
ICAM1 intercellular adhesion molecule 1 2.34618
MAN2A1 mannosidase, alpha, class 2A, member 1 2.3404
CDA cytidine deaminase 2.33215
CREG1 cellular repressor of E1A-stimulated genes 1 2.318
ZFYVE16 zinc finger, FYVE domain containing 16 2.3165
SLC12A8 solute carrier family 12, member 8 2.3117
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.28525
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.2752
ATG4A autophagy related 4A, cysteine peptidase 2.275
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.27455
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 2.27325
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.27225
GRB14 growth factor receptor-bound protein 14 2.2636
CLEC16A C-type lectin domain family 16, member A 2.2529
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.2309
HAND2 heart and neural crest derivatives expressed 2 2.2309
TNIK TRAF2 and NCK interacting kinase 2.2276
PRR15L proline rich 15-like 2.22665
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 2.2265
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.213
STMN4 stathmin-like 4 2.20905
SNRPN small nuclear ribonucleoprotein polypeptide N 2.20445
NUP62CL nucleoporin 62kDa C-terminal like 2.20415
MFN1 mitofusin 1 2.19567
SLC67A1 solute carrier family 67 member 1 2.19145
PUM1 pumilio RNA-binding family member 1 2.18105
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.16385
PRDX1 peroxiredoxin 1 2.14695
VNN1 vanin 1 2.1416
CNPY3 canopy FGF signaling regulator 3 2.1396
DSG2 desmoglein 2 2.1394
PHGDH phosphoglycerate dehydrogenase 2.13908
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.131
ZNF638 zinc finger protein 638 2.1296
SEC31A SEC31 homolog A (S. cerevisiae) 2.11865
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.0875
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 2.0716
PARP2 poly (ADP-ribose) polymerase 2 2.06508
PLXNC1 plexin C1 2.05985
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.05508
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.05225
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.05015
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.03105
NKX2-1 NK2 homeobox 1 2.03032
RSU1 Ras suppressor protein 1 2.0183
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.0182
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.01675
RBM41 RNA binding motif protein 41 2.01565
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.01465
CYCS cytochrome c, somatic 2.0111
BLVRA biliverdin reductase A 2.00775
ENTREP1 endosomal transmembrane epsin interactor 1 2.00515

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
CCNB2 cyclin B2 -7.4323
TLCD3A TLC domain containing 3A -7.28245
NUP85 nucleoporin 85kDa -5.96105
CDC20 cell division cycle 20 -5.74475
ZW10 zw10 kinetochore protein -5.18435
LDHD lactate dehydrogenase D -5.0305
COG7 component of oligomeric golgi complex 7 -5.0
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.7813
PCNA proliferating cell nuclear antigen -4.66275
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.52555
CCDC86 coiled-coil domain containing 86 -4.50385
PECR peroxisomal trans-2-enoyl-CoA reductase -4.0362
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.8245
EIF5 eukaryotic translation initiation factor 5 -3.77242
SLC35F2 solute carrier family 35, member F2 -3.5507
PLK1 polo-like kinase 1 -3.48065
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.37895
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.2684
GRWD1 glutamate-rich WD repeat containing 1 -3.2515
GNAS GNAS complex locus -3.2212
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.174
NCAPD2 non-SMC condensin I complex, subunit D2 -2.90225
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.8292
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.78507
WDR7 WD repeat domain 7 -2.7756
CIRBP cold inducible RNA binding protein -2.77383
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.72605
TSPOAP1 TSPO associated protein 1 -2.7153
ZNF274 zinc finger protein 274 -2.70405
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.67625
SLC38A12 solute carrier family 38 member 12 -2.66735
TBC1D10C TBC1 domain family, member 10C -2.6651
MRPS7 mitochondrial ribosomal protein S7 -2.64055
UBE2C ubiquitin-conjugating enzyme E2C -2.62475
TENT5C terminal nucleotidyltransferase 5C -2.5851
CDK1 cyclin-dependent kinase 1 -2.58363
CDC25B cell division cycle 25B -2.5813
TBC1D31 TBC1 domain family, member 31 -2.5398
TMEM94 transmembrane protein 94 -2.53905
EDN1 endothelin 1 -2.52135
CSF3 colony stimulating factor 3 (granulocyte) -2.4372
CCNA2 cyclin A2 -2.42712
IRF3 interferon regulatory factor 3 -2.41575
DDB2 damage-specific DNA binding protein 2, 48kDa -2.4084
LOC122539214 Zinc finger protein LOC122539214 -2.3731
ANKMY2 ankyrin repeat and MYND domain containing 2 -2.35685
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.35615
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.3346
MIS18A MIS18 kinetochore protein A -2.31675
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.31585
YEATS4 YEATS domain containing 4 -2.31045
CCT2 chaperonin containing TCP1, subunit 2 (beta) -2.29868
KDM8 lysine (K)-specific demethylase 8 -2.296
UTP25 UTP25 small subunit processome component -2.28177
LBR lamin B receptor -2.2752
MIDEAS mitotic deacetylase associated SANT domain protein -2.26275
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.25515
BDKRB1 bradykinin receptor B1 -2.25155
TMEM100 transmembrane protein 100 -2.24565
BIRC5 baculoviral IAP repeat containing 5 -2.22972
SMNDC1 survival motor neuron domain containing 1 -2.2236
PCYOX1L prenylcysteine oxidase 1 like -2.2181
KCTD2 potassium channel tetramerization domain containing 2 -2.21445
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.17865
TCEAL4 transcription elongation factor A (SII)-like 4 -2.1766
RIN1 Ras and Rab interactor 1 -2.17035
NFIL3 nuclear factor, interleukin 3 regulated -2.1579
PEG10 paternally expressed 10 -2.14757
AURKB aurora kinase B -2.1474
PUF60 poly-U binding splicing factor 60KDa -2.13695
CCNE1 cyclin E1 -2.12165
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.12075
CD96 CD96 molecule -2.11125
WDR26 WD repeat domain 26 -2.10275
ATRNL1 attractin-like 1 -2.08715
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.08365
FANCF Fanconi anemia, complementation group F -2.07245
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.06725
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.0602
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.057
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.0494
CDR2L cerebellar degeneration-related protein 2-like -2.04045
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -2.0337
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -2.0176
ZFP30 ZFP30 zinc finger protein -2.0142
EML1 echinoderm microtubule associated protein like 1 -2.00915
TRIM56 tripartite motif containing 56 -2.0053
ADGRA2 adhesion G protein-coupled receptor A2 -2.0051
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.0027
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -2.00215