CRCGN011_HEPG2_24H:G06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triphenyl phosphate 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN011_HEPG2_24H:G06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.4638
DENND2D DENN/MADD domain containing 2D 5.3965
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.24715
CHMP6 charged multivesicular body protein 6 5.2424
CSK c-src tyrosine kinase 4.91515
CIAO3 cytosolic iron-sulfur assembly component 3 4.90345
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.5333
STIMATE STIM activating enhancer 4.3109
PPARG peroxisome proliferator-activated receptor gamma 4.20255
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.1893
BIRC2 baculoviral IAP repeat containing 2 3.91965
PFKL phosphofructokinase, liver 3.7179
MAP7 microtubule-associated protein 7 3.6867
VGLL4 vestigial-like family member 4 3.38825
SOCS2 suppressor of cytokine signaling 2 3.32647
KLHL9 kelch-like family member 9 3.16195
AKT1 v-akt murine thymoma viral oncogene homolog 1 3.08895
COQ8A coenzyme Q8A 3.00115
ERBB3 erb-b2 receptor tyrosine kinase 3 2.9795
SSBP2 single-stranded DNA binding protein 2 2.9245
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.864
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.66135
GPER1 G protein-coupled estrogen receptor 1 2.62173
MMP2 matrix metallopeptidase 2 2.5291
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.48605
NMU neuromedin U 2.41335
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.3686
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.2691
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.2098
SFTPD surfactant protein D 2.18005
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.15775
PODXL2 podocalyxin-like 2 2.13435
TRMT61B tRNA methyltransferase 61B 2.0995
INF2 inverted formin, FH2 and WH2 domain containing 2.09135
HPCAL1 hippocalcin-like 1 2.085
RANGAP1 Ran GTPase activating protein 1 2.07037
GATD3 glutamine amidotransferase class 1 domain containing 3 2.05872
RASIP1 Ras interacting protein 1 2.0312
METRN meteorin, glial cell differentiation regulator 2.02815
TGM3 transglutaminase 3 2.01035

decreased expression

Symbol Name Standardized Value
SCAND1 SCAN domain containing 1 -5.67705
UGDH UDP-glucose 6-dehydrogenase -5.48955
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.39595
LDHD lactate dehydrogenase D -5.24985
FBXL12 F-box and leucine-rich repeat protein 12 -5.08935
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0
COG2 component of oligomeric golgi complex 2 -4.92225
PCNA proliferating cell nuclear antigen -4.7455
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.62155
BLCAP bladder cancer associated protein -4.4846
LYPLA1 lysophospholipase I -3.8563
CD58 CD58 molecule -3.70832
GDF15 growth differentiation factor 15 -3.69165
GNAS GNAS complex locus -3.66016
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.3577
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.25685
WASHC4 WASH complex subunit 4 -3.07007
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.00153
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.69865
S100PBP S100P binding protein -2.53425
AGBL2 ATP/GTP binding protein-like 2 -2.5079
OXA1L oxidase (cytochrome c) assembly 1-like -2.49035
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.3982
NGRN neugrin, neurite outgrowth associated -2.3743
RAI14 retinoic acid induced 14 -2.3585
PRPF4 pre-mRNA processing factor 4 -2.26853
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.22085
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.14475
RGS2 regulator of G-protein signaling 2 -2.08845
FOXO4 forkhead box O4 -2.06305
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.05795
CNOT2 CCR4-NOT transcription complex, subunit 2 -2.0307
PLEKHS1 pleckstrin homology domain containing, family S member 1 -2.00305