CRCGN011_HEPG2_24H:G08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN011_HEPG2_24H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NMU neuromedin U 5.77175
E2F2 E2F transcription factor 2 5.16985
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0321
UBQLN2 ubiquilin 2 5.0114
SLC75A1 solute carrier family 75 member 1 4.8823
AMDHD2 amidohydrolase domain containing 2 4.5848
CHMP6 charged multivesicular body protein 6 4.50475
CCL2 chemokine (C-C motif) ligand 2 4.07895
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.01435
ANO1 anoctamin 1, calcium activated chloride channel 4.00815
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.0048
KIF5C kinesin family member 5C 3.9832
MAP7 microtubule-associated protein 7 3.97697
HOXA10 homeobox A10 3.78075
DYNLT3 dynein, light chain, Tctex-type 3 3.2203
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.19
PMM2 phosphomannomutase 2 3.1172
EPN2 epsin 2 3.11703
TXNL4B thioredoxin-like 4B 2.98125
SHB Src homology 2 domain containing adaptor protein B 2.9727
MMP2 matrix metallopeptidase 2 2.64345
GRB10 growth factor receptor-bound protein 10 2.64202
DIPK1A divergent protein kinase domain 1A 2.6165
MAG myelin associated glycoprotein 2.51405
DENND2D DENN/MADD domain containing 2D 2.4946
RNF167 ring finger protein 167 2.40545
H2BC21 H2B clustered histone 21 2.35065
TMEM184B transmembrane protein 184B 2.3134
RFTN1 raftlin, lipid raft linker 1 2.27955
TBXA2R thromboxane A2 receptor 2.27354
HOXD12 homeobox D12 2.24075
CCNF cyclin F 2.22645
RAI14 retinoic acid induced 14 2.2092
TESK1 testis-specific kinase 1 2.1853
APLP1 amyloid beta (A4) precursor-like protein 1 2.16245
GBX2 gastrulation brain homeobox 2 2.1486
NONO non-POU domain containing, octamer-binding 2.14218
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.08795
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.05875
NTF3 neurotrophin 3 2.0532
CYCS cytochrome c, somatic 2.04825
STIP1 stress-induced phosphoprotein 1 2.03597
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.0349
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.00115

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.50685
UGDH UDP-glucose 6-dehydrogenase -5.0745
PLK1 polo-like kinase 1 -4.8186
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.65675
TLCD3A TLC domain containing 3A -4.41825
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.2301
ADI1 acireductone dioxygenase 1 -3.84435
GRWD1 glutamate-rich WD repeat containing 1 -3.8359
RHEB Ras homolog enriched in brain -3.72647
NGRN neugrin, neurite outgrowth associated -3.64205
ARID5B AT rich interactive domain 5B (MRF1-like) -3.4034
PCNA proliferating cell nuclear antigen -3.3054
SPAG4 sperm associated antigen 4 -3.19155
CCNB2 cyclin B2 -2.98215
ACAA1 acetyl-CoA acyltransferase 1 -2.93598
HEATR1 HEAT repeat containing 1 -2.92383
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.72705
SCAND1 SCAN domain containing 1 -2.7107
PLCD1 phospholipase C, delta 1 -2.66845
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.49048
NRIP1 nuclear receptor interacting protein 1 -2.3893
REEP5 receptor accessory protein 5 -2.25887
FOS FBJ murine osteosarcoma viral oncogene homolog -2.23485
GSAP gamma-secretase activating protein -2.17378
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.0845
RSRC1 arginine/serine-rich coiled-coil 1 -2.02605
CENPC centromere protein C -2.02195
RBL2 retinoblastoma-like 2 -2.01872
NQO1 NAD(P)H dehydrogenase, quinone 1 -2.01022
BICRA BRD4 interacting chromatin remodeling complex associated protein -2.0086