CRCGN011_HEPG2_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN011_HEPG2_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.18595
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.07905
PPARG peroxisome proliferator-activated receptor gamma 4.9585
NOTCH1 notch 1 4.9034
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.88335
MYLK myosin light chain kinase 4.811
C2CD2 C2 calcium-dependent domain containing 2 4.7622
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.4816
GSTZ1 glutathione S-transferase zeta 1 4.24205
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.18825
ATP11B ATPase, class VI, type 11B 4.10215
FPGS folylpolyglutamate synthase 3.0686
TIAM1 T-cell lymphoma invasion and metastasis 1 2.88645
VGLL4 vestigial-like family member 4 2.87995
GARRE1 granule associated Rac and RHOG effector 1 2.8146
RNF167 ring finger protein 167 2.5115
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.3572
KLHL9 kelch-like family member 9 2.32912
GPATCH8 G patch domain containing 8 2.21878
COQ8A coenzyme Q8A 2.20155
CAB39 calcium binding protein 39 2.1736
HBB hemoglobin, beta 2.1373
HBA1 hemoglobin, alpha 1 2.05077
CRIPTO3 cripto, EGF-CFC family member 3 2.02335

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.79255
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.4386
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.25135
LDHD lactate dehydrogenase D -5.0532
DNM1L dynamin 1-like -5.0184
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.52715
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.85415
GNAS GNAS complex locus -3.62919
OXA1L oxidase (cytochrome c) assembly 1-like -3.53365
ADI1 acireductone dioxygenase 1 -3.1437
PRPF4 pre-mRNA processing factor 4 -2.6395
TBC1D31 TBC1 domain family, member 31 -2.1244
WASHC4 WASH complex subunit 4 -2.08563
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.08515
FBXO7 F-box protein 7 -2.05195