CRCGN011_HEPG2_24H:G10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

107 genes differentially expressed following the CRCGN011_HEPG2_24H:G10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.6485
NMU neuromedin U 5.4814
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.3886
CSK c-src tyrosine kinase 5.35735
PPARG peroxisome proliferator-activated receptor gamma 5.19315
HEBP1 heme binding protein 1 5.0298
CARMIL1 capping protein regulator and myosin 1 linker 1 4.8239
PEX11A peroxisomal biogenesis factor 11 alpha 4.72272
E2F2 E2F transcription factor 2 4.648
MYLK myosin light chain kinase 4.5847
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.35295
TESK1 testis-specific kinase 1 4.3406
SSBP2 single-stranded DNA binding protein 2 3.8987
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.6586
DENND2D DENN/MADD domain containing 2D 3.65005
CHN1 chimerin 1 3.4383
RNF167 ring finger protein 167 3.31695
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.1283
VAV3 vav 3 guanine nucleotide exchange factor 3.10775
MEST mesoderm specific transcript 3.10225
CSRP2 cysteine and glycine-rich protein 2 3.05358
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.84595
KLHL9 kelch-like family member 9 2.74303
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.68615
WNT16 wingless-type MMTV integration site family, member 16 2.6666
CCNF cyclin F 2.64208
ZNF395 zinc finger protein 395 2.54227
MAGEA6 melanoma antigen family A6 2.53947
GPATCH8 G patch domain containing 8 2.5369
GPER1 G protein-coupled estrogen receptor 1 2.48172
ADGRE5 adhesion G protein-coupled receptor E5 2.4304
PROSER1 proline and serine rich 1 2.39445
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.383
DCTN3 dynactin 3 (p22) 2.37825
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.37212
REG1A regenerating islet-derived 1 alpha 2.35315
MSANTD3-TMEFF1 MSANTD3-TMEFF1 readthrough 2.3303
UFM1 ubiquitin-fold modifier 1 2.3209
TMPRSS3 transmembrane protease, serine 3 2.3045
NVL nuclear VCP-like 2.30105
CUTA cutA divalent cation tolerance homolog (E. coli) 2.29495
ZNF711 zinc finger protein 711 2.2827
CD40 CD40 molecule, TNF receptor superfamily member 5 2.28066
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.2776
DYNLT3 dynein, light chain, Tctex-type 3 2.27205
TREM1 triggering receptor expressed on myeloid cells 1 2.2655
ENDOU endonuclease, polyU-specific 2.2155
ZSCAN9 zinc finger and SCAN domain containing 9 2.2113
STON1 stonin 1 2.206
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 2.19285
CDH10 cadherin 10, type 2 (T2-cadherin) 2.18295
FAM149A family with sequence similarity 149, member A 2.17938
ZNF589 zinc finger protein 589 2.1689
TRIM39-RPP21 TRIM39-RPP21 readthrough 2.15545
COQ8A coenzyme Q8A 2.14185
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.11235
NOTCH4 notch 4 2.10395
ZSCAN26 zinc finger and SCAN domain containing 26 2.0786
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.07785
SARS1 seryl-tRNA synthetase 1 2.07665
REG1B regenerating islet-derived 1 beta 2.06195
CSNK2B casein kinase 2, beta polypeptide 2.05195
SERTAD2 SERTA domain containing 2 2.04045
WDR33 WD repeat domain 33 2.04035
PARP6 poly (ADP-ribose) polymerase family, member 6 2.0371
ZNF232 zinc finger protein 232 2.02085
ZFP36 ZFP36 ring finger protein 2.0131
HOXD9 homeobox D9 2.00705
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2.00463
DENND5B DENN/MADD domain containing 5B 2.004

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.221
HEATR1 HEAT repeat containing 1 -5.94275
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.98075
LDHD lactate dehydrogenase D -4.9694
CCDC86 coiled-coil domain containing 86 -4.53285
MAP7 microtubule-associated protein 7 -4.51993
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.29605
GTPBP8 GTP-binding protein 8 (putative) -4.1977
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.06635
SESN1 sestrin 1 -3.6007
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.33085
IFRD2 interferon-related developmental regulator 2 -3.0673
CCNB2 cyclin B2 -2.93795
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.86739
FBXO7 F-box protein 7 -2.85065
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.8058
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.4988
IFNGR1 interferon gamma receptor 1 -2.48747
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.34695
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.31335
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.298
CD58 CD58 molecule -2.29718
NUP62 nucleoporin 62kDa -2.24032
NPDC1 neural proliferation, differentiation and control, 1 -2.20715
HOXB13 homeobox B13 -2.1824
OXA1L oxidase (cytochrome c) assembly 1-like -2.14095
CHURC1-FNTB CHURC1-FNTB readthrough -2.11818
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.1168
FERMT1 fermitin family member 1 -2.09825
NRIP1 nuclear receptor interacting protein 1 -2.09238
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.0762
TMOD3 tropomodulin 3 (ubiquitous) -2.06335
PRPF19 pre-mRNA processing factor 19 -2.05745
STK32B serine/threonine kinase 32B -2.0454
PROS1 protein S (alpha) -2.0416
SLC44A4 solute carrier family 44, member 4 -2.03265
DUSP13A dual specificity phosphatase 13A -2.0281