CRCGN011_HEPG2_24H:G11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN011_HEPG2_24H:G11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 8.9143
LCN2 lipocalin 2 7.56945
NMU neuromedin U 5.05935
PPARG peroxisome proliferator-activated receptor gamma 4.92265
UBQLN2 ubiquilin 2 4.74645
STK10 serine/threonine kinase 10 4.6181
ABHD4 abhydrolase domain containing 4 4.338
STIMATE STIM activating enhancer 3.9608
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.94485
SSBP2 single-stranded DNA binding protein 2 3.64612
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.6113
CIRBP cold inducible RNA binding protein 3.02658
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.91925
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.90394
ZNF589 zinc finger protein 589 2.71558
SCRN1 secernin 1 2.52985
CRELD2 cysteine-rich with EGF-like domains 2 2.3302
SOCS2 suppressor of cytokine signaling 2 2.19737
FPGS folylpolyglutamate synthase 2.1821
CHEK2 checkpoint kinase 2 2.16645
LOC122526780 uncharacterized LOC122526780 2.10945
ZFP36 ZFP36 ring finger protein 2.05315
PPP6C protein phosphatase 6, catalytic subunit 2.032

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.4084
COG4 component of oligomeric golgi complex 4 -5.32565
CD320 CD320 molecule -5.28995
FASTKD5 FAST kinase domains 5 -5.1888
KDM3A lysine (K)-specific demethylase 3A -5.1518
GDF15 growth differentiation factor 15 -5.0
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
GTPBP8 GTP-binding protein 8 (putative) -4.6449
CCDC86 coiled-coil domain containing 86 -4.53285
FGFR4 fibroblast growth factor receptor 4 -4.4931
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.95945
HMG20B high mobility group 20B -3.89355
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.518
GNAS GNAS complex locus -3.51145
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.0874
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.95758
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.88265
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.6419
HEATR1 HEAT repeat containing 1 -2.61437
NRIP1 nuclear receptor interacting protein 1 -2.53013
FOS FBJ murine osteosarcoma viral oncogene homolog -2.4412
PCDH17 protocadherin 17 -2.40265
SELE selectin E -2.3611
TRAT1 T cell receptor associated transmembrane adaptor 1 -2.20025
CAVIN2 caveolae associated protein 2 -2.1582
GRB7 growth factor receptor-bound protein 7 -2.1304
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.1086
RAB1B RAB1B, member RAS oncogene family -2.07035
PDHX pyruvate dehydrogenase complex, component X -2.06067
ADGRL4 adhesion G protein-coupled receptor L4 -2.0565
CORO7-PAM16 CORO7-PAM16 readthrough -2.0389
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 -2.00595