CRCGN011_HEPG2_24H:G12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c blue no. 2 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN011_HEPG2_24H:G12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MINDY1 MINDY lysine 48 deubiquitinase 1 5.47775
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.45975
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.41035
E2F2 E2F transcription factor 2 5.37095
ADRB2 adrenoceptor beta 2, surface 5.1497
MYLK myosin light chain kinase 5.035
STIMATE STIM activating enhancer 4.81555
CSK c-src tyrosine kinase 4.66275
LAGE3 L antigen family, member 3 4.5679
PPARG peroxisome proliferator-activated receptor gamma 4.5155
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.3607
GPER1 G protein-coupled estrogen receptor 1 3.87423
MEST mesoderm specific transcript 3.6124
TLR4 toll-like receptor 4 3.61095
TESK1 testis-specific kinase 1 3.4803
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.38895
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.27945
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.12455
SSBP2 single-stranded DNA binding protein 2 3.00058
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.76977
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.55995
ZNF589 zinc finger protein 589 2.51182
ADGRE5 adhesion G protein-coupled receptor E5 2.49295
FBP1 fructose-1,6-bisphosphatase 1 2.3602
ITM2A integral membrane protein 2A 2.33368
CCDC28A coiled-coil domain containing 28A 2.3168
LAG3 lymphocyte-activation gene 3 2.21365
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.18075
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.17795
CRELD1 cysteine-rich with EGF-like domains 1 2.1754
EMCN endomucin 2.1678
CYCS cytochrome c, somatic 2.14805
OR7E24 olfactory receptor, family 7, subfamily E, member 24 2.07835
JCHAIN joining chain of multimeric IgA and IgM 2.04585
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.04175
TSPAN6 tetraspanin 6 2.02087
DMRT1 doublesex and mab-3 related transcription factor 1 2.0146
ZNF37A zinc finger protein 37A 2.00985
OLFML2A olfactomedin-like 2A 2.0091
COL9A3 collagen, type IX, alpha 3 2.00005

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -7.2698
CDC20 cell division cycle 20 -5.5741
PLK1 polo-like kinase 1 -5.40635
KDM3A lysine (K)-specific demethylase 3A -5.06735
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.0
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.9444
COG2 component of oligomeric golgi complex 2 -4.88455
LDHD lactate dehydrogenase D -4.81815
CCDC86 coiled-coil domain containing 86 -4.43985
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.76922
CCNB2 cyclin B2 -3.4936
WASHC4 WASH complex subunit 4 -3.3949
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.3737
HEATR1 HEAT repeat containing 1 -3.05732
MACF1 microtubule-actin crosslinking factor 1 -2.99964
PCNA proliferating cell nuclear antigen -2.9197
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.91919
NRIP1 nuclear receptor interacting protein 1 -2.90992
ZNF586 zinc finger protein 586 -2.7806
YME1L1 YME1-like 1 ATPase -2.73227
RNF167 ring finger protein 167 -2.6036
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.5354
GAB2 GRB2-associated binding protein 2 -2.5187
SNX11 sorting nexin 11 -2.46672
IPO13 importin 13 -2.3485
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.343
FOS FBJ murine osteosarcoma viral oncogene homolog -2.3383
CR2 complement component (3d/Epstein Barr virus) receptor 2 -2.21385
KRT10 keratin 10, type I -2.09503
PSRC1 proline/serine-rich coiled-coil 1 -2.0897
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.07615
GPSM2 G-protein signaling modulator 2 -2.01692
LGMN legumain -2.0081
NFE2L2 nuclear factor, erythroid 2-like 2 -2.0064