CRCGN011_HEPG2_24H:G17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description withaferin-a 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

326 genes differentially expressed following the CRCGN011_HEPG2_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 10.0
ABHD4 abhydrolase domain containing 4 10.0
HMOX1 heme oxygenase 1 8.4209
TXNRD1 thioredoxin reductase 1 8.01835
MCOLN1 mucolipin 1 6.72525
FOSL1 FOS-like antigen 1 6.3081
CNPY3 canopy FGF signaling regulator 3 6.21225
CBR1 carbonyl reductase 1 6.2002
TIMP2 TIMP metallopeptidase inhibitor 2 5.78195
SQSTM1 sequestosome 1 5.5891
RPL39L ribosomal protein L39-like 5.23655
KLHL21 kelch-like family member 21 5.1997
BZW2 basic leucine zipper and W2 domains 2 5.1402
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.0
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.5279
KEAP1 kelch-like ECH-associated protein 1 4.4788
HSPA1A heat shock 70kDa protein 1A 4.4718
CCL2 chemokine (C-C motif) ligand 2 4.29275
MVP major vault protein 4.26445
ALAS1 5'-aminolevulinate synthase 1 4.09235
PPARG peroxisome proliferator-activated receptor gamma 4.05475
UGDH UDP-glucose 6-dehydrogenase 3.9643
ZW10 zw10 kinetochore protein 3.86735
EPHB2 EPH receptor B2 3.86555
MICALL1 MICAL-like 1 3.70845
TEX10 testis expressed 10 3.5967
TATDN2 TatD DNase domain containing 2 3.54485
VAT1 vesicle amine transport 1 3.4499
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.3723
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.33535
RNASE7 ribonuclease, RNase A family, 7 3.31313
TERF2IP telomeric repeat binding factor 2, interacting protein 3.2738
GCLM glutamate-cysteine ligase, modifier subunit 3.26125
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.25475
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.1533
RBKS ribokinase 3.1367
H2BC12 H2B clustered histone 12 3.12385
COG4 component of oligomeric golgi complex 4 3.12265
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.1042
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 3.09915
STX3 syntaxin 3 3.09487
BIRC2 baculoviral IAP repeat containing 2 3.0833
C5 complement component 5 3.0826
EEIG1 estrogen-induced osteoclastogenesis regulator 1 3.0741
CHEK1 checkpoint kinase 1 3.07148
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.04685
FOXO4 forkhead box O4 3.0342
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 3.01965
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 3.01315
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.99145
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.9891
TBC1D2 TBC1 domain family, member 2 2.9636
CCDC92 coiled-coil domain containing 92 2.8566
INPP1 inositol polyphosphate-1-phosphatase 2.82495
GSR glutathione reductase 2.7709
TSKU tsukushi, small leucine rich proteoglycan 2.7573
NQO1 NAD(P)H dehydrogenase, quinone 1 2.75013
DYNLT3 dynein, light chain, Tctex-type 3 2.73625
RNMT RNA (guanine-7-) methyltransferase 2.68412
AARS1 alanyl-tRNA synthetase 1 2.6825
GADD45A growth arrest and DNA-damage-inducible, alpha 2.6823
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.66755
TOM1 target of myb1 (chicken) 2.65895
TRAM2 translocation associated membrane protein 2 2.63755
PTK7 protein tyrosine kinase 7 (inactive) 2.63165
RAB21 RAB21, member RAS oncogene family 2.63165
AATF apoptosis antagonizing transcription factor 2.61335
BAG2 BCL2-associated athanogene 2 2.583
KCTD5 potassium channel tetramerization domain containing 5 2.566
CTSL cathepsin L 2.5558
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 2.5329
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.53185
CHMP1A charged multivesicular body protein 1A 2.50895
ZNF532 zinc finger protein 532 2.49755
SLC61A1 solute carrier family 61 member 1 2.496
PIR pirin (iron-binding nuclear protein) 2.49175
PDPN podoplanin 2.473
EPHB3 EPH receptor B3 2.46793
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.4669
MAD2L1BP MAD2L1 binding protein 2.44065
MRPL37 mitochondrial ribosomal protein L37 2.43145
MFSD1 major facilitator superfamily domain containing 1 2.4305
HSPA4L heat shock 70kDa protein 4-like 2.4259
SKIC2 SKI2 subunit of superkiller complex 2.422
COL17A1 collagen, type XVII, alpha 1 2.4095
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.40507
MPZL1 myelin protein zero-like 1 2.39456
RPP38 ribonuclease P/MRP 38kDa subunit 2.3894
CLN3 ceroid-lipofuscinosis, neuronal 3 2.36505
TMEM50A transmembrane protein 50A 2.35265
ATG9A autophagy related 9A 2.33945
RETN resistin 2.33795
MED27 mediator complex subunit 27 2.33645
TRIM16 tripartite motif containing 16 2.33475
SMG6 SMG6 nonsense mediated mRNA decay factor 2.3221
MMP3 matrix metallopeptidase 3 2.3176
ELL2 elongation factor, RNA polymerase II, 2 2.30395
SYNRG synergin, gamma 2.29163
UIMC1 ubiquitin interaction motif containing 1 2.2897
NPC1 Niemann-Pick disease, type C1 2.28375
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.2831
RNF19B ring finger protein 19B 2.2797
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.27665
MNT MAX network transcriptional repressor 2.2697
STXBP1 syntaxin binding protein 1 2.26865
TARS1 threonyl-tRNA synthetase 1 2.26655
LSR lipolysis stimulated lipoprotein receptor 2.25845
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.25807
RAI14 retinoic acid induced 14 2.2553
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.2314
SAFB scaffold attachment factor B 2.23095
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.2232
SBNO1 strawberry notch homolog 1 (Drosophila) 2.22225
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 2.214
RFWD3 ring finger and WD repeat domain 3 2.2077
ZDHHC18 zinc finger, DHHC-type containing 18 2.1956
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 2.19297
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.18875
PIAS4 protein inhibitor of activated STAT, 4 2.17838
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.17815
VAC14 Vac14 homolog (S. cerevisiae) 2.1728
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.17215
SDF2 stromal cell-derived factor 2 2.1703
ALG3 ALG3, alpha-1,3- mannosyltransferase 2.16995
PRSS22 protease, serine, 22 2.15775
BCCIP BRCA2 and CDKN1A interacting protein 2.12325
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.12185
DNM1L dynamin 1-like 2.11695
AURKA aurora kinase A 2.11553
AARSD1 alanyl-tRNA synthetase domain containing 1 2.1016
CDC45 cell division cycle 45 2.1008
REEP5 receptor accessory protein 5 2.09678
LAMB3 laminin, beta 3 2.0911
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.08875
FBXO7 F-box protein 7 2.08765
REX1BD required for excision 1-B domain containing 2.08467
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.0819
CMTR1 cap methyltransferase 1 2.08045
SIRT2 sirtuin 2 2.0778
GPN2 GPN-loop GTPase 2 2.07695
IST1 increased sodium tolerance 1 homolog (yeast) 2.0764
BAG3 BCL2-associated athanogene 3 2.0763
TIPIN TIMELESS interacting protein 2.0711
GHR growth hormone receptor 2.0694
FAM53C family with sequence similarity 53, member C 2.0649
NUAK2 NUAK family, SNF1-like kinase, 2 2.0636
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.06335
DOLK dolichol kinase 2.0624
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.05735
SAC3D1 SAC3 domain containing 1 2.04885
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.04535
EDC4 enhancer of mRNA decapping 4 2.0412
CENPN centromere protein N 2.04047
NKIRAS2 NFKB inhibitor interacting Ras-like 2 2.04023
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.03775
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.0344
RALB v-ral simian leukemia viral oncogene homolog B 2.02933
EHD4 EH-domain containing 4 2.0282
SPC25 SPC25, NDC80 kinetochore complex component 2.0232
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.02215
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.02135
TMCO1 transmembrane and coiled-coil domains 1 2.00695
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.00615
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.0019

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -10.0
PCCB propionyl CoA carboxylase, beta polypeptide -7.58635
GNAS GNAS complex locus -7.29754
B4GAT1 beta-1,4-glucuronyltransferase 1 -6.61415
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.82485
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.553
LDHD lactate dehydrogenase D -5.4237
CCDC86 coiled-coil domain containing 86 -5.3558
ISOC1 isochorismatase domain containing 1 -5.16555
CCNB1 cyclin B1 -5.1462
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.0
PECR peroxisomal trans-2-enoyl-CoA reductase -4.8156
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.6294
CHMP4B charged multivesicular body protein 4B -4.62197
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.6081
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -4.4791
COG2 component of oligomeric golgi complex 2 -4.38125
ACAA1 acetyl-CoA acyltransferase 1 -4.37435
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.29128
S100A4 S100 calcium binding protein A4 -4.1499
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.07225
INTS3 integrator complex subunit 3 -3.9605
EIF5 eukaryotic translation initiation factor 5 -3.87639
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.8697
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.8091
PGM1 phosphoglucomutase 1 -3.79525
EXT1 exostosin glycosyltransferase 1 -3.79265
TRAP1 TNF receptor-associated protein 1 -3.7613
OXA1L oxidase (cytochrome c) assembly 1-like -3.5737
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.51915
FGFR4 fibroblast growth factor receptor 4 -3.47102
C2CD5 C2 calcium-dependent domain containing 5 -3.4189
GLRX5 glutaredoxin 5 -3.3887
NRIP1 nuclear receptor interacting protein 1 -3.2556
UBA2 ubiquitin-like modifier activating enzyme 2 -3.2525
TOP2A topoisomerase (DNA) II alpha 170kDa -3.21242
TSPAN4 tetraspanin 4 -3.11595
DCK deoxycytidine kinase -3.03775
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.99325
ITGB1BP1 integrin beta 1 binding protein 1 -2.92965
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.92935
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.8501
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.84325
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.7976
TCEAL4 transcription elongation factor A (SII)-like 4 -2.7949
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.76435
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.74445
GET1 guided entry of tail-anchored proteins factor 1 -2.7406
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.72995
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.66625
HEATR1 HEAT repeat containing 1 -2.66615
STMN1 stathmin 1 -2.63075
CCNB2 cyclin B2 -2.6196
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.61625
CAPNS1 calpain, small subunit 1 -2.6112
RFC2 replication factor C (activator 1) 2, 40kDa -2.6019
GAMT guanidinoacetate N-methyltransferase -2.5995
HMGA2 high mobility group AT-hook 2 -2.59545
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.59237
FXYD1 FXYD domain containing ion transport regulator 1 -2.58
RERGL RERG/RAS-like -2.5708
OXR1 oxidation resistance 1 -2.5384
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.5274
VDAC1 voltage-dependent anion channel 1 -2.5234
PARP2 poly (ADP-ribose) polymerase 2 -2.49768
PNKP polynucleotide kinase 3'-phosphatase -2.49255
TM7SF2 transmembrane 7 superfamily member 2 -2.4629
MRPS27 mitochondrial ribosomal protein S27 -2.4564
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.44815
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -2.4312
HLF hepatic leukemia factor -2.41433
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.4126
TRMT5 tRNA methyltransferase 5 -2.4073
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.39785
CDK4 cyclin-dependent kinase 4 -2.39605
HNMT histamine N-methyltransferase -2.38568
YME1L1 YME1-like 1 ATPase -2.38253
ARMCX2 armadillo repeat containing, X-linked 2 -2.36445
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -2.36212
CASQ2 calsequestrin 2 (cardiac muscle) -2.3523
RAP1A RAP1A, member of RAS oncogene family -2.3498
ERBB3 erb-b2 receptor tyrosine kinase 3 -2.34657
ZNHIT1 zinc finger, HIT-type containing 1 -2.34415
RNF167 ring finger protein 167 -2.34225
RPH3A rabphilin 3A -2.3364
N4BP2L1 NEDD4 binding protein 2-like 1 -2.32905
TAGLN2 transgelin 2 -2.32258
ADD3 adducin 3 (gamma) -2.31393
FGF4 fibroblast growth factor 4 -2.3065
E2F5 E2F transcription factor 5, p130-binding -2.29985
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.2974
LUM lumican -2.2843
NCKIPSD NCK interacting protein with SH3 domain -2.28245
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.26045
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) -2.2586
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.25362
ASGR1 asialoglycoprotein receptor 1 -2.25125
LOC128966570 alpha-amylase 1B -2.2364
KLHDC2 kelch domain containing 2 -2.2346
TUBB4A tubulin, beta 4A class IVa -2.23315
ASGR2 asialoglycoprotein receptor 2 -2.2213
COL3A1 collagen, type III, alpha 1 -2.22058
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.2171
LRRC17 leucine rich repeat containing 17 -2.21695
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.203
CCN3 cellular communication network factor 3 -2.19895
RPL36AL ribosomal protein L36a-like -2.1967
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.19365
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.19325
C4A complement component 4A (Rodgers blood group) -2.18337
DUSP6 dual specificity phosphatase 6 -2.1833
MYH10 myosin, heavy chain 10, non-muscle -2.17922
NPY1R neuropeptide Y receptor Y1 -2.17465
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -2.17015
CCNG1 cyclin G1 -2.1686
TMPRSS5 transmembrane protease, serine 5 -2.16435
MTERF3 mitochondrial transcription termination factor 3 -2.15925
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.15815
PCP4 Purkinje cell protein 4 -2.1511
FHIT fragile histidine triad -2.1495
KIAA1549L KIAA1549-like -2.14755
GPR22 G protein-coupled receptor 22 -2.14095
MYO3A myosin IIIA -2.13615
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.13465
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.13385
CCS copper chaperone for superoxide dismutase -2.12755
BHLHE40 basic helix-loop-helix family, member e40 -2.12367
CRELD1 cysteine-rich with EGF-like domains 1 -2.12275
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -2.11902
RABL6 RAB, member RAS oncogene family-like 6 -2.1177
TRIM13 tripartite motif containing 13 -2.1065
SRSF7 serine/arginine-rich splicing factor 7 -2.09388
SYN1 synapsin I -2.0868
OR7A5 olfactory receptor, family 7, subfamily A, member 5 -2.0867
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.08665
SECTM1 secreted and transmembrane 1 -2.082
SV2B synaptic vesicle glycoprotein 2B -2.0815
SIPA1L1 signal-induced proliferation-associated 1 like 1 -2.07955
RGS4 regulator of G-protein signaling 4 -2.06912
RGS5 regulator of G-protein signaling 5 -2.06908
TSPAN6 tetraspanin 6 -2.06628
PDHB pyruvate dehydrogenase (lipoamide) beta -2.06507
GTF3A general transcription factor IIIA -2.06265
GSTCD glutathione S-transferase, C-terminal domain containing -2.05915
ATRNL1 attractin-like 1 -2.05445
NNT nicotinamide nucleotide transhydrogenase -2.0442
EVL Enah/Vasp-like -2.0337
MAPK10 mitogen-activated protein kinase 10 -2.0303
DENND2D DENN/MADD domain containing 2D -2.0274
PRAF2 PRA1 domain family, member 2 -2.0244
NHLRC2 NHL repeat containing 2 -2.02235
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.01995
MYLK3 myosin light chain kinase 3 -2.01865
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -2.01863
TFB1M transcription factor B1, mitochondrial -2.0177
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.01695
PLP1 proteolipid protein 1 -2.0162
DCAF13 DDB1 and CUL4 associated factor 13 -2.0149
PCYOX1 prenylcysteine oxidase 1 -2.008
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.00735
GUSB glucuronidase, beta -2.00425
RASL10A RAS-like, family 10, member A -2.0035