| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | withaferin-a 0.62 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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184 genes differentially expressed following the CRCGN011_HEPG2_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SNAP25 | synaptosomal-associated protein, 25kDa | 8.05902 |
| HMOX1 | heme oxygenase 1 | 7.6643 |
| HSPA1A | heat shock 70kDa protein 1A | 7.0759 |
| TXNRD1 | thioredoxin reductase 1 | 6.7639 |
| FOSL1 | FOS-like antigen 1 | 5.7949 |
| ABHD4 | abhydrolase domain containing 4 | 5.6986 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 5.34048 |
| E2F2 | E2F transcription factor 2 | 5.2534 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 5.24305 |
| NOSIP | nitric oxide synthase interacting protein | 5.2397 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 5.0765 |
| KLHL21 | kelch-like family member 21 | 4.9591 |
| TLR4 | toll-like receptor 4 | 4.8055 |
| UGDH | UDP-glucose 6-dehydrogenase | 4.4907 |
| LCN2 | lipocalin 2 | 4.0021 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 3.85585 |
| SQSTM1 | sequestosome 1 | 3.85418 |
| MCOLN1 | mucolipin 1 | 3.79585 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 3.6808 |
| KEAP1 | kelch-like ECH-associated protein 1 | 3.55125 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 3.42568 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | 3.4068 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 3.3323 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 3.28575 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.268 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 3.18915 |
| TATDN2 | TatD DNase domain containing 2 | 3.1475 |
| FASTKD5 | FAST kinase domains 5 | 3.0617 |
| BIRC2 | baculoviral IAP repeat containing 2 | 3.0527 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.99235 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.94855 |
| SNX7 | sorting nexin 7 | 2.92385 |
| C5 | complement component 5 | 2.89505 |
| CBR1 | carbonyl reductase 1 | 2.88125 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 2.874 |
| JADE2 | jade family PHD finger 2 | 2.79367 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.71985 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.7059 |
| TPD52L2 | tumor protein D52-like 2 | 2.62125 |
| LSG1 | large 60S subunit nuclear export GTPase 1 | 2.60335 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 2.5955 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 2.5831 |
| FPGS | folylpolyglutamate synthase | 2.5643 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 2.52925 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | 2.4808 |
| MRGBP | MRG/MORF4L binding protein | 2.4568 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 2.4516 |
| KDM3A | lysine (K)-specific demethylase 3A | 2.41815 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 2.416 |
| EPPK1 | epiplakin 1 | 2.3827 |
| NEFL | neurofilament, light polypeptide | 2.3731 |
| JMJD6 | jumonji domain containing 6 | 2.36872 |
| MMP1 | matrix metallopeptidase 1 | 2.3663 |
| CCNF | cyclin F | 2.35763 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.33945 |
| MUC7 | mucin 7, secreted | 2.3369 |
| CCDC92 | coiled-coil domain containing 92 | 2.3319 |
| LPO | lactoperoxidase | 2.3276 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 2.32377 |
| MAGEA4 | melanoma antigen family A4 | 2.3096 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 2.2874 |
| TTBK2 | tau tubulin kinase 2 | 2.274 |
| ANKRD12 | ankyrin repeat domain 12 | 2.25953 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 2.24745 |
| RPAP2 | RNA polymerase II associated protein 2 | 2.2376 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 2.2294 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 2.22885 |
| TMEM109 | transmembrane protein 109 | 2.21335 |
| CTSL | cathepsin L | 2.19445 |
| SUSD5 | sushi domain containing 5 | 2.19425 |
| GSR | glutathione reductase | 2.1915 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 2.186 |
| EMC3 | ER membrane protein complex subunit 3 | 2.16455 |
| EPHA3 | EPH receptor A3 | 2.16195 |
| AIM2 | absent in melanoma 2 | 2.15965 |
| PCDHB16 | protocadherin beta 16 | 2.15055 |
| BLM | Bloom syndrome, RecQ helicase-like | 2.14205 |
| NRXN1 | neurexin 1 | 2.14095 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.12672 |
| H2BC12 | H2B clustered histone 12 | 2.11767 |
| OTUD3 | OTU deubiquitinase 3 | 2.11725 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.09955 |
| HAL | histidine ammonia-lyase | 2.09365 |
| GLRB | glycine receptor, beta | 2.0876 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 2.0864 |
| MDN1 | MDN1, midasin homolog (yeast) | 2.0752 |
| SMR3B | submaxillary gland androgen regulated protein 3B | 2.0731 |
| NOX4 | NADPH oxidase 4 | 2.06435 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.05925 |
| GRIA1 | glutamate receptor, ionotropic, AMPA 1 | 2.03312 |
| HSPA1B | heat shock 70kDa protein 1B | 2.0321 |
| NEFM | neurofilament, medium polypeptide | 2.0292 |
| PMM2 | phosphomannomutase 2 | 2.0263 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 2.0193 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 | 2.0122 |
| MVP | major vault protein | 2.0074 |
| SH3GL2 | SH3-domain GRB2-like 2 | 2.00565 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -8.5773 |
| CCNB2 | cyclin B2 | -7.60465 |
| COG2 | component of oligomeric golgi complex 2 | -6.00145 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.52725 |
| LDHD | lactate dehydrogenase D | -5.36565 |
| DSG2 | desmoglein 2 | -5.222 |
| TUBB6 | tubulin, beta 6 class V | -5.10685 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.8242 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.56978 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -4.46105 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.4436 |
| ADI1 | acireductone dioxygenase 1 | -4.19055 |
| PGM1 | phosphoglucomutase 1 | -4.0993 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -3.85165 |
| CDC20 | cell division cycle 20 | -3.84315 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -3.81865 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.5458 |
| RHEB | Ras homolog enriched in brain | -3.51673 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.4404 |
| INTS3 | integrator complex subunit 3 | -3.40535 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.27375 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -3.25305 |
| TRAPPC3 | trafficking protein particle complex 3 | -3.23623 |
| GNAS | GNAS complex locus | -3.17447 |
| ACTR1B | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | -3.1542 |
| STAMBP | STAM binding protein | -3.08875 |
| TRIM13 | tripartite motif containing 13 | -3.04395 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -3.0354 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.87208 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -2.8684 |
| TSPAN4 | tetraspanin 4 | -2.86777 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.86707 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.76463 |
| CDK5 | cyclin-dependent kinase 5 | -2.73165 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -2.7291 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.68215 |
| RNF167 | ring finger protein 167 | -2.62205 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -2.6035 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -2.5821 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | -2.57843 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -2.54453 |
| PEG10 | paternally expressed 10 | -2.5 |
| HADH | hydroxyacyl-CoA dehydrogenase | -2.48208 |
| F7 | coagulation factor VII (serum prothrombin conversion accelerator) | -2.4546 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.44307 |
| KLHDC2 | kelch domain containing 2 | -2.44235 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.43275 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.3836 |
| DCK | deoxycytidine kinase | -2.3815 |
| PDE9A | phosphodiesterase 9A | -2.37045 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -2.3538 |
| PRR5L | proline rich 5 like | -2.34555 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.3328 |
| RPS5 | ribosomal protein S5 | -2.32445 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -2.2964 |
| HMGA2 | high mobility group AT-hook 2 | -2.2757 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -2.25275 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -2.2421 |
| MIS12 | MIS12 kinetochore complex component | -2.2397 |
| DNALI1 | dynein, axonemal, light intermediate chain 1 | -2.2347 |
| HMG20B | high mobility group 20B | -2.2342 |
| TRMT61B | tRNA methyltransferase 61B | -2.22775 |
| FASTK | Fas-activated serine/threonine kinase | -2.2243 |
| IPO13 | importin 13 | -2.19875 |
| PPCS | phosphopantothenoylcysteine synthetase | -2.19735 |
| NIT1 | nitrilase 1 | -2.16475 |
| MTMR4 | myotubularin related protein 4 | -2.16223 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -2.15355 |
| DYNC2I1 | dynein 2 intermediate chain 1 | -2.15145 |
| NPY1R | neuropeptide Y receptor Y1 | -2.1503 |
| PIMREG | PICALM interacting mitotic regulator | -2.1501 |
| PDZRN3 | PDZ domain containing ring finger 3 | -2.1195 |
| TRAP1 | TNF receptor-associated protein 1 | -2.1182 |
| NRTN | neurturin | -2.11605 |
| CRYL1 | crystallin, lambda 1 | -2.1108 |
| PNKP | polynucleotide kinase 3'-phosphatase | -2.0846 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -2.0622 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -2.06155 |
| NOP53 | NOP53 ribosome biogenesis factor | -2.051 |
| NNT | nicotinamide nucleotide transhydrogenase | -2.03677 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.0303 |
| PDHB | pyruvate dehydrogenase (lipoamide) beta | -2.02775 |
| TTLL3 | tubulin tyrosine ligase-like family member 3 | -2.02492 |
| MDH1 | malate dehydrogenase 1, NAD (soluble) | -2.0237 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -2.0228 |
| TSC22D1 | TSC22 domain family, member 1 | -2.0176 |
| IGF2 | insulin-like growth factor 2 | -2.0005 |
