CRCGN011_HEPG2_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description quinapril 21.47 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN011_HEPG2_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
JADE2 jade family PHD finger 2 5.54212
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.39385
MYLK myosin light chain kinase 4.92965
NOTCH1 notch 1 4.7229
GATA3 GATA binding protein 3 4.61098
SNAP25 synaptosomal-associated protein, 25kDa 4.39062
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.28705
KDM5A lysine (K)-specific demethylase 5A 4.0323
CXCL2 chemokine (C-X-C motif) ligand 2 3.9772
HDGFL3 HDGF like 3 3.96315
PCDHB11 protocadherin beta 11 3.94917
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.7013
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.52785
ZBTB38 zinc finger and BTB domain containing 38 2.6844
ZNF862 zinc finger protein 862 2.563
AQP2 aquaporin 2 (collecting duct) 2.3251
CTSL cathepsin L 2.3156
CGGBP1 CGG triplet repeat binding protein 1 2.27785
CYREN cell cycle regulator of NHEJ 2.2535
NUP205 nucleoporin 205kDa 2.23025
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.21565
UMOD uromodulin 2.1801
SMG8 SMG8 nonsense mediated mRNA decay factor 2.1779
GSK3B glycogen synthase kinase 3 beta 2.1778
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.1279
ADAM10 ADAM metallopeptidase domain 10 2.12352
CDKN3 cyclin-dependent kinase inhibitor 3 2.0673
CCNE2 cyclin E2 2.05085
CYCS cytochrome c, somatic 2.00675

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -5.8088
C2CD5 C2 calcium-dependent domain containing 5 -5.2534
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.80065
ZNF586 zinc finger protein 586 -4.66815
CHMP4B charged multivesicular body protein 4B -4.4072
FGFR4 fibroblast growth factor receptor 4 -4.01695
OXA1L oxidase (cytochrome c) assembly 1-like -3.718
ADI1 acireductone dioxygenase 1 -3.71585
PEG10 paternally expressed 10 -3.29725
WASHC4 WASH complex subunit 4 -3.21447
TM9SF2 transmembrane 9 superfamily member 2 -3.0883
PDZD2 PDZ domain containing 2 -3.02138
PCNA proliferating cell nuclear antigen -2.9303
RYR1 ryanodine receptor 1 (skeletal) -2.9216
ETNK1 ethanolamine kinase 1 -2.76288
SLC35F2 solute carrier family 35, member F2 -2.71895
EXT1 exostosin glycosyltransferase 1 -2.7144
AURKB aurora kinase B -2.6928
MACF1 microtubule-actin crosslinking factor 1 -2.67433
TBCB tubulin folding cofactor B -2.57105
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.55192
ZNF551 zinc finger protein 551 -2.4645
NT5C 5', 3'-nucleotidase, cytosolic -2.4529
TPM2 tropomyosin 2 (beta) -2.44963
CAPNS1 calpain, small subunit 1 -2.40065
VDAC1 voltage-dependent anion channel 1 -2.3878
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.30695
MIMS2 mitochondrial inner membrane scaffold 2 -2.2257
PSENEN presenilin enhancer gamma secretase subunit -2.2178
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.21365
MAG myelin associated glycoprotein -2.16175
ACVR2A activin A receptor, type IIA -2.11825
ZNF146 zinc finger protein 146 -2.0973
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.0877
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.0789
ARHGAP5 Rho GTPase activating protein 5 -2.0633
ZFYVE16 zinc finger, FYVE domain containing 16 -2.05585
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -2.00335