CRCGN011_HEPG2_24H:G20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description quinapril 10.74 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN011_HEPG2_24H:G20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 10.0
CSK c-src tyrosine kinase 5.48555
MYLK myosin light chain kinase 5.17205
MAMLD1 mastermind-like domain containing 1 4.66275
STK10 serine/threonine kinase 10 4.62528
ADRB2 adrenoceptor beta 2, surface 4.59835
CIAO3 cytosolic iron-sulfur assembly component 3 4.36775
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.1508
SNAP25 synaptosomal-associated protein, 25kDa 4.04798
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.97755
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.64365
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.6175
SOCS2 suppressor of cytokine signaling 2 3.1653
IDE insulin-degrading enzyme 3.1285
NOSIP nitric oxide synthase interacting protein 2.80825
CGRRF1 cell growth regulator with ring finger domain 1 2.76885
HLA-DRA major histocompatibility complex, class II, DR alpha 2.7582
CEP57 centrosomal protein 57kDa 2.7539
FZD7 frizzled class receptor 7 2.72195
CHN1 chimerin 1 2.58025
CBR3 carbonyl reductase 3 2.54215
TBXA2R thromboxane A2 receptor 2.37875
ARID4A AT rich interactive domain 4A (RBP1-like) 2.34125
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.27315
HARS1 histidyl-tRNA synthetase 1 2.273
NMU neuromedin U 2.26735
SLC10A3 solute carrier family 10, member 3 2.26035
TPD52L2 tumor protein D52-like 2 2.23405
AKAP12 A kinase (PRKA) anchor protein 12 2.2295
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.20915
TWSG1 twisted gastrulation BMP signaling modulator 1 2.1312
DCP2 decapping mRNA 2 2.12885
SKIC8 SKI8 subunit of superkiller complex 2.12783
GATA2 GATA binding protein 2 2.1265
CRYAB crystallin, alpha B 2.12135
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 2.1082
FAM13B family with sequence similarity 13, member B 2.09505
TMEM45A transmembrane protein 45A 2.0686
ADGRE5 adhesion G protein-coupled receptor E5 2.06025
ZBTB35 zinc finger and BTB domain containing 35 2.04518
NMI N-myc (and STAT) interactor 2.03825
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 2.02303
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.0071

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.93925
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.9288
TRIB3 tribbles pseudokinase 3 -4.9053
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.86735
TRAP1 TNF receptor-associated protein 1 -4.82515
CCNB1 cyclin B1 -4.7964
CD320 CD320 molecule -4.69355
PECR peroxisomal trans-2-enoyl-CoA reductase -4.6246
MRPS16 mitochondrial ribosomal protein S16 -4.54295
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.07125
OXA1L oxidase (cytochrome c) assembly 1-like -4.0552
ZMIZ1 zinc finger, MIZ-type containing 1 -3.98905
ADI1 acireductone dioxygenase 1 -3.70265
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.28435
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.88367
HMG20B high mobility group 20B -2.72818
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 -2.5147
CFHR2 complement factor H-related 2 -2.4568
PPT1 palmitoyl-protein thioesterase 1 -2.3766
NKX3-2 NK3 homeobox 2 -2.3414
SHTN1 shootin 1 -2.3181
FGF21 fibroblast growth factor 21 -2.30275
FGL2 fibrinogen-like 2 -2.30245
CDK5RAP3 CDK5 regulatory subunit associated protein 3 -2.23115
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.22556
ITGB1BP1 integrin beta 1 binding protein 1 -2.21615
PCDH17 protocadherin 17 -2.1793
RBM34 RNA binding motif protein 34 -2.1607
TBC1D22B TBC1 domain family, member 22B -2.1523
MTOR mechanistic target of rapamycin (serine/threonine kinase) -2.1301
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.12605
MKS1 Meckel syndrome, type 1 -2.11785
PLVAP plasmalemma vesicle associated protein -2.1059
RING1 ring finger protein 1 -2.02248
NCSTN nicastrin -2.0193