CRCGN011_HEPG2_24H:G22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description quinapril 2.68 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN011_HEPG2_24H:G22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 5.26895
EVL Enah/Vasp-like 5.175
ATP11B ATPase, class VI, type 11B 4.7957
CCL2 chemokine (C-C motif) ligand 2 4.6943
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.483
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.36455
MSRA methionine sulfoxide reductase A 4.28355
ABHD6 abhydrolase domain containing 6 4.26743
GPER1 G protein-coupled estrogen receptor 1 3.87672
MAP7 microtubule-associated protein 7 3.2704
CYCS cytochrome c, somatic 3.13535
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.92427
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.8509
KLHL9 kelch-like family member 9 2.8308
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.75695
TRIM13 tripartite motif containing 13 2.57785
LOC122526780 uncharacterized LOC122526780 2.46975
ZNF589 zinc finger protein 589 2.45537
LCN2 lipocalin 2 2.32765
EPHA3 EPH receptor A3 2.31515
DRC3 dynein regulatory complex subunit 3 2.206
IMPACT impact RWD domain protein 2.1427
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.12695
GSR glutathione reductase 2.1044
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 2.04605

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -7.57925
HAT1 histone acetyltransferase 1 -5.87025
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.86935
KDM3A lysine (K)-specific demethylase 3A -5.33725
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.95525
BLVRA biliverdin reductase A -4.87182
GOLT1B golgi transport 1B -4.7153
COG2 component of oligomeric golgi complex 2 -4.70595
VAT1 vesicle amine transport 1 -4.5528
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.31245
DDIT4 DNA-damage-inducible transcript 4 -4.225
CDC25B cell division cycle 25B -4.1366
CCNB2 cyclin B2 -3.97485
ADI1 acireductone dioxygenase 1 -3.9439
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.73518
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.62515
TLCD3A TLC domain containing 3A -3.55705
GNAS GNAS complex locus -3.37458
PCNA proliferating cell nuclear antigen -3.26925
GDF15 growth differentiation factor 15 -3.24075
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.1743
RNF167 ring finger protein 167 -3.16875
SNX11 sorting nexin 11 -2.6612
CD58 CD58 molecule -2.4394
CAMK1D calcium/calmodulin-dependent protein kinase ID -2.39015
ZHX2 zinc fingers and homeoboxes 2 -2.31095
CCNH cyclin H -2.3042
INPP5K inositol polyphosphate-5-phosphatase K -2.25437
NPDC1 neural proliferation, differentiation and control, 1 -2.25305
HTRA2 HtrA serine peptidase 2 -2.22552
GRB7 growth factor receptor-bound protein 7 -2.17885
YIPF3 Yip1 domain family, member 3 -2.1736
BFAR bifunctional apoptosis regulator -2.10285
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.10225
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.0325
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 -2.01185