CRCGN011_HEPG2_24H:G23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description quinapril 1.34 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

144 genes differentially expressed following the CRCGN011_HEPG2_24H:G23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 5.70205
TLR4 toll-like receptor 4 5.392
SPTAN1 spectrin, alpha, non-erythrocytic 1 5.38165
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.25991
RPL39L ribosomal protein L39-like 5.0832
CXCL2 chemokine (C-X-C motif) ligand 2 5.05845
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.04195
PRKCD protein kinase C, delta 4.9946
CSK c-src tyrosine kinase 4.66275
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.65615
PPARG peroxisome proliferator-activated receptor gamma 4.63975
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.63215
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.6224
EPHA3 EPH receptor A3 4.6141
CIAO3 cytosolic iron-sulfur assembly component 3 4.4626
CDC45 cell division cycle 45 4.4347
STIMATE STIM activating enhancer 4.43095
PEX11A peroxisomal biogenesis factor 11 alpha 4.28247
IDE insulin-degrading enzyme 4.19708
GPER1 G protein-coupled estrogen receptor 1 3.5488
WDTC1 WD and tetratricopeptide repeats 1 3.29227
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.975
AICDA activation-induced cytidine deaminase 2.8434
SKIC2 SKI2 subunit of superkiller complex 2.7515
MAGEA11 melanoma antigen family A11 2.69275
SOCS2 suppressor of cytokine signaling 2 2.65558
LMCD1 LIM and cysteine-rich domains 1 2.6193
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.6121
COL11A1 collagen, type XI, alpha 1 2.56257
CLEC4E C-type lectin domain family 4, member E 2.4912
RNF13 ring finger protein 13 2.48927
DEFB126 defensin, beta 126 2.48595
GALR1 galanin receptor 1 2.48365
DAND5 DAN domain family member 5, BMP antagonist 2.4759
RYR1 ryanodine receptor 1 (skeletal) 2.37175
COL8A1 collagen, type VIII, alpha 1 2.36855
RIT2 Ras-like without CAAX 2 2.3639
RGSL1 regulator of G-protein signaling like 1 2.34855
SRP9 signal recognition particle 9kDa 2.3413
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.32155
TNIP1 TNFAIP3 interacting protein 1 2.31715
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.29625
CDO1 cysteine dioxygenase type 1 2.29205
ZNF804A zinc finger protein 804A 2.2869
ALPL alkaline phosphatase, liver/bone/kidney 2.2689
FOXN2 forkhead box N2 2.2686
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 2.2581
SLC30A3 solute carrier family 30 (zinc transporter), member 3 2.2498
WWC2 WW and C2 domain containing 2 2.24885
CD40 CD40 molecule, TNF receptor superfamily member 5 2.22596
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 2.22417
MTNAP1 mitochondrial nucleoid associated protein 1 2.21545
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 2.21005
FPR2 formyl peptide receptor 2 2.20948
S100A5 S100 calcium binding protein A5 2.1948
MDM4 MDM4, p53 regulator 2.1927
TMEM94 transmembrane protein 94 2.18785
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 2.1846
SPIN2A spindlin family, member 2A 2.1846
KRT37 keratin 37, type I 2.1738
KLHL9 kelch-like family member 9 2.16157
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.1579
ATP13A3 ATPase type 13A3 2.15468
LIMD2 LIM domain containing 2 2.15405
MARCHF2 membrane associated ring-CH-type finger 2 2.1492
GRIA4 glutamate receptor, ionotropic, AMPA 4 2.14525
TGFA transforming growth factor, alpha 2.14067
MAT1A methionine adenosyltransferase I, alpha 2.12795
TBCCD1 TBCC domain containing 1 2.12745
G6PC2 glucose-6-phosphatase, catalytic, 2 2.12565
F9 coagulation factor IX 2.1149
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.11425
CTPS2 CTP synthase 2 2.1128
FMO3 flavin containing monooxygenase 3 2.11238
GRM6 glutamate receptor, metabotropic 6 2.1123
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.1037
LDHC lactate dehydrogenase C 2.10115
MEFV Mediterranean fever 2.09475
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.0929
SLC49A3 solute carrier family 49 member 3 2.0857
COQ8A coenzyme Q8A 2.0847
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.08135
GDI1 GDP dissociation inhibitor 1 2.0799
GPX5 glutathione peroxidase 5 2.07687
TXLNG taxilin gamma 2.0736
WRNIP1 Werner helicase interacting protein 1 2.07165
KCTD14 potassium channel tetramerization domain containing 14 2.0675
PEDS1 plasmanylethanolamine desaturase 1 2.06255
CEP57 centrosomal protein 57kDa 2.06068
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 2.05938
TAS2R7 taste receptor, type 2, member 7 2.0592
DUOX2 dual oxidase 2 2.05135
PHTF1 putative homeodomain transcription factor 1 2.03955
KRT32 keratin 32, type I 2.0386
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2.03423
PRRX1 paired related homeobox 1 2.03405
TLR8 toll-like receptor 8 2.01565
TGFBR1 transforming growth factor, beta receptor 1 2.01135
SCYL2 SCY1-like 2 (S. cerevisiae) 2.01125
MAGEB4 melanoma antigen family B4 2.0105
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.00895
CCNF cyclin F 2.0044
GABPA GA binding protein transcription factor, alpha subunit 60kDa 2.0016

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.19525
DNM1L dynamin 1-like -5.95275
PLK1 polo-like kinase 1 -5.75255
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.42035
C2CD5 C2 calcium-dependent domain containing 5 -5.3246
COG7 component of oligomeric golgi complex 7 -5.31675
CDC20 cell division cycle 20 -5.31545
LDHD lactate dehydrogenase D -5.1124
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0
MRPS2 mitochondrial ribosomal protein S2 -4.8297
VAT1 vesicle amine transport 1 -4.7964
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.21285
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.95245
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.47015
DERA deoxyribose-phosphate aldolase (putative) -3.38795
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.3274
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.31574
OXA1L oxidase (cytochrome c) assembly 1-like -3.01445
DCTN5 dynactin 5 (p25) -2.73295
GALP galanin-like peptide -2.61375
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.53824
PAEP progestagen-associated endometrial protein -2.49225
ZBTB24 zinc finger and BTB domain containing 24 -2.42705
FCGBP Fc fragment of IgG binding protein -2.35835
CDC25B cell division cycle 25B -2.3347
SLC35F2 solute carrier family 35, member F2 -2.2726
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.26455
MED21 mediator complex subunit 21 -2.1565
CLASRP CLK4-associating serine/arginine rich protein -2.1188
PROS1 protein S (alpha) -2.1153
IGLL1 immunoglobulin lambda-like polypeptide 1 -2.104
NSF N-ethylmaleimide-sensitive factor -2.0947
HEATR1 HEAT repeat containing 1 -2.0939
ZCCHC10 zinc finger, CCHC domain containing 10 -2.07075
TBC1D13 TBC1 domain family, member 13 -2.0389
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.0264
MPHOSPH6 M-phase phosphoprotein 6 -2.0242
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.0237
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.01297
STX18 syntaxin 18 -2.007
UBFD1 ubiquitin family domain containing 1 -2.0018