| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-aminoanthraquinone 39.4 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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122 genes differentially expressed following the CRCGN011_HEPG2_24H:H01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 10.0 |
| PPARG | peroxisome proliferator-activated receptor gamma | 6.7254 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 6.20425 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 5.5276 |
| MAMLD1 | mastermind-like domain containing 1 | 5.1051 |
| CCDC85B | coiled-coil domain containing 85B | 5.0245 |
| CBR3 | carbonyl reductase 3 | 4.82105 |
| LOXL1 | lysyl oxidase-like 1 | 4.66275 |
| E2F2 | E2F transcription factor 2 | 4.5396 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.3029 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 4.16195 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.96835 |
| TXNRD1 | thioredoxin reductase 1 | 3.5514 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 3.5197 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.5192 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 3.5159 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.24133 |
| FASTKD5 | FAST kinase domains 5 | 3.14725 |
| JADE2 | jade family PHD finger 2 | 3.11285 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.06985 |
| PRKCH | protein kinase C, eta | 3.03115 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.99455 |
| LCN2 | lipocalin 2 | 2.93035 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 2.91595 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.8671 |
| RXYLT1 | ribitol xylosyltransferase 1 | 2.825 |
| ANAPC1 | anaphase promoting complex subunit 1 | 2.80775 |
| CTSL | cathepsin L | 2.75795 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.65285 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 2.61415 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.59115 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 2.52585 |
| PLS1 | plastin 1 | 2.4924 |
| LOC124907782 | dual specificity protein phosphatase 22 | 2.42715 |
| CCND1 | cyclin D1 | 2.4038 |
| PHGDH | phosphoglycerate dehydrogenase | 2.3999 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.39195 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 2.37805 |
| STAT5A | signal transducer and activator of transcription 5A | 2.20075 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 2.19077 |
| CHN1 | chimerin 1 | 2.1772 |
| CCNF | cyclin F | 2.15307 |
| MCM3 | minichromosome maintenance complex component 3 | 2.13165 |
| IFI27 | interferon, alpha-inducible protein 27 | 2.12245 |
| AHR | aryl hydrocarbon receptor | 2.10355 |
| ABHD4 | abhydrolase domain containing 4 | 2.099 |
| ZNF318 | zinc finger protein 318 | 2.09138 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | 2.0892 |
| BAD | BCL2-associated agonist of cell death | 2.08005 |
| SLC43A1 | solute carrier family 43 (amino acid system L transporter), member 1 | 2.07945 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 2.0776 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 2.0505 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 2.03085 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 2.0303 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 2.0215 |
| GAA | glucosidase, alpha; acid | 2.0212 |
| SLC30A10 | solute carrier family 30, member 10 | 2.0082 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ANKRD10 | ankyrin repeat domain 10 | -5.7026 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -5.64105 |
| PLK1 | polo-like kinase 1 | -5.04795 |
| ADI1 | acireductone dioxygenase 1 | -5.01055 |
| SLC35F2 | solute carrier family 35, member F2 | -4.8746 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -4.83585 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -4.6256 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.61 |
| LDHD | lactate dehydrogenase D | -4.6028 |
| PCNA | proliferating cell nuclear antigen | -4.553 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -4.48295 |
| RGS2 | regulator of G-protein signaling 2 | -4.4739 |
| ZNF274 | zinc finger protein 274 | -3.98325 |
| DSG2 | desmoglein 2 | -3.9317 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.7696 |
| TCTN1 | tectonic family member 1 | -3.7611 |
| CHMP4B | charged multivesicular body protein 4B | -3.75655 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.74105 |
| GNAS | GNAS complex locus | -3.64576 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.4409 |
| CAB39 | calcium binding protein 39 | -3.24565 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -3.1624 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -3.09757 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -3.0593 |
| ZW10 | zw10 kinetochore protein | -3.0369 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.89365 |
| BZW2 | basic leucine zipper and W2 domains 2 | -2.7485 |
| NMRK2 | nicotinamide riboside kinase 2 | -2.6801 |
| SHARPIN | SHANK-associated RH domain interactor | -2.6754 |
| WDR76 | WD repeat domain 76 | -2.66385 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -2.6474 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -2.62715 |
| THAP1 | THAP domain containing, apoptosis associated protein 1 | -2.5108 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | -2.5065 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -2.49465 |
| SQOR | sulfide quinone oxidoreductase | -2.48275 |
| KLHL21 | kelch-like family member 21 | -2.4616 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.42595 |
| STAMBP | STAM binding protein | -2.4117 |
| CENPT | centromere protein T | -2.37535 |
| CDC42SE1 | CDC42 small effector 1 | -2.3682 |
| RNF167 | ring finger protein 167 | -2.32775 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.3223 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -2.3162 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -2.3038 |
| SPAG4 | sperm associated antigen 4 | -2.27545 |
| BAK1 | BCL2-antagonist/killer 1 | -2.24085 |
| ZNF816 | zinc finger protein 816 | -2.1802 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.1761 |
| PMCH | pro-melanin-concentrating hormone | -2.16885 |
| HEMK2 | HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine | -2.15815 |
| CCDC106 | coiled-coil domain containing 106 | -2.1486 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | -2.13995 |
| CYB561D2 | cytochrome b561 family, member D2 | -2.138 |
| CNOT3 | CCR4-NOT transcription complex, subunit 3 | -2.13347 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -2.12345 |
| MRPL44 | mitochondrial ribosomal protein L44 | -2.1097 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.0721 |
| CDCP1 | CUB domain containing protein 1 | -2.06855 |
| DERL2 | derlin 2 | -2.03955 |
| GRINA | glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) | -2.0334 |
| RBM48 | RNA binding motif protein 48 | -2.027 |
| PFKP | phosphofructokinase, platelet | -2.02635 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | -2.01865 |
| CRIPT | cysteine-rich PDZ-binding protein | -2.0145 |
