CRCGN011_HEPG2_24H:H04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminoanthraquinone 4.92 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

296 genes differentially expressed following the CRCGN011_HEPG2_24H:H04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 6.61415
STIMATE STIM activating enhancer 5.94245
E2F2 E2F transcription factor 2 5.42755
MOK MOK protein kinase 5.41475
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.326
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.14285
TERT telomerase reverse transcriptase 5.1165
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 4.98785
PLS1 plastin 1 4.82435
CSK c-src tyrosine kinase 4.66275
NMU neuromedin U 4.64335
CXCR4 chemokine (C-X-C motif) receptor 4 4.41538
PEX11A peroxisomal biogenesis factor 11 alpha 4.15868
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.1219
MEST mesoderm specific transcript 4.11795
ADAT1 adenosine deaminase, tRNA-specific 1 4.0844
CXCL2 chemokine (C-X-C motif) ligand 2 4.0271
SNAP25 synaptosomal-associated protein, 25kDa 3.8565
CTSL cathepsin L 3.72265
MSRA methionine sulfoxide reductase A 3.65335
WDTC1 WD and tetratricopeptide repeats 1 3.60938
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.5712
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.56675
ZNF589 zinc finger protein 589 3.28947
PMM2 phosphomannomutase 2 3.262
CAPNS1 calpain, small subunit 1 3.18775
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.17025
ANO1 anoctamin 1, calcium activated chloride channel 3.11515
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.03835
NOSIP nitric oxide synthase interacting protein 2.99925
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.92975
NEMF nuclear export mediator factor 2.92925
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.9146
NHLRC2 NHL repeat containing 2 2.91055
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.88825
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.8651
KLHL21 kelch-like family member 21 2.82325
ETAA1 Ewing tumor-associated antigen 1 2.8003
CCP110 centriolar coiled coil protein 110kDa 2.7953
CCDC86 coiled-coil domain containing 86 2.79195
CYCS cytochrome c, somatic 2.7615
ABHD4 abhydrolase domain containing 4 2.7459
RRAGA Ras-related GTP binding A 2.74095
BAD BCL2-associated agonist of cell death 2.73378
PTK2 protein tyrosine kinase 2 2.68565
COG2 component of oligomeric golgi complex 2 2.6848
RTL8A retrotransposon Gag like 8A 2.6162
TREM2 triggering receptor expressed on myeloid cells 2 2.61485
SPRED2 sprouty-related, EVH1 domain containing 2 2.6106
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.5433
DNAH7 dynein, axonemal, heavy chain 7 2.5349
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 2.4975
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.46195
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.46165
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.4399
TSNAXIP1 translin-associated factor X interacting protein 1 2.4345
WNT16 wingless-type MMTV integration site family, member 16 2.43245
HAND1 heart and neural crest derivatives expressed 1 2.41685
WASF3 WAS protein family, member 3 2.4108
VAMP7 vesicle-associated membrane protein 7 2.3991
EVL Enah/Vasp-like 2.3938
SNX13 sorting nexin 13 2.38013
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.379
DTWD1 DTW domain containing 1 2.37875
MEOX2 mesenchyme homeobox 2 2.3773
SH3D19 SH3 domain containing 19 2.37367
TMOD1 tropomodulin 1 2.37245
LPAR3 lysophosphatidic acid receptor 3 2.3688
BCL9 B-cell CLL/lymphoma 9 2.34815
MBD5 methyl-CpG binding domain protein 5 2.34715
TRAPPC3 trafficking protein particle complex 3 2.3454
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.34265
PRAMEF10 PRAME family member 10 2.3371
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.3367
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.3339
ECD ecdysoneless homolog (Drosophila) 2.3314
PSG2 pregnancy specific beta-1-glycoprotein 2 2.3262
POPDC3 popeye domain containing 3 2.3243
CILK1 ciliogenesis associated kinase 1 2.3239
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.3233
CHN1 chimerin 1 2.32245
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 2.31735
PARG poly (ADP-ribose) glycohydrolase 2.312
BPHL biphenyl hydrolase-like (serine hydrolase) 2.3095
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 2.30925
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.3079
MEIS2 Meis homeobox 2 2.3007
TSGA10 testis specific, 10 2.28125
FXYD1 FXYD domain containing ion transport regulator 1 2.27735
DGCR6L DiGeorge syndrome critical region gene 6-like 2.27515
SMN2 survival of motor neuron 2, centromeric 2.2711
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.2711
MBNL2 muscleblind-like splicing regulator 2 2.27097
ATG14 autophagy related 14 2.26625
KLHDC3 kelch domain containing 3 2.25688
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.2541
RABL3 RAB, member of RAS oncogene family-like 3 2.25305
GATA2 GATA binding protein 2 2.24952
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.2413
FAM163A family with sequence similarity 163, member A 2.2395
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.2384
ZDHHC4 zinc finger, DHHC-type containing 4 2.23785
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.237
MYNN myoneurin 2.2321
ANKRD10 ankyrin repeat domain 10 2.231
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.22825
DENND2B DENN domain containing 2B 2.22755
LTA4H leukotriene A4 hydrolase 2.22735
DNAI7 dynein axonemal intermediate chain 7 2.22365
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.2228
CHST10 carbohydrate sulfotransferase 10 2.221
DNAH6 dynein, axonemal, heavy chain 6 2.22065
ATG4A autophagy related 4A, cysteine peptidase 2.22035
TRHDE thyrotropin-releasing hormone degrading enzyme 2.1989
HAUS6 HAUS augmin-like complex, subunit 6 2.19265
FPGS folylpolyglutamate synthase 2.1857
LOC102724428 serine/threonine-protein kinase SIK1 2.178
THAP10 THAP domain containing 10 2.17685
KRT75 keratin 75, type II 2.1741
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.174
FOXJ3 forkhead box J3 2.17107
DGKH diacylglycerol kinase, eta 2.15585
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.155
KRT9 keratin 9, type I 2.1549
MTERF3 mitochondrial transcription termination factor 3 2.1504
PRKCD protein kinase C, delta 2.1452
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.1315
CREG1 cellular repressor of E1A-stimulated genes 1 2.12925
NLRP2B NLR family pyrin domain containing 2B 2.12825
TEC tec protein tyrosine kinase 2.1181
ZNF274 zinc finger protein 274 2.1164
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.11595
CPOX coproporphyrinogen oxidase 2.1145
TTC21B tetratricopeptide repeat domain 21B 2.11215
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.1082
TUBA4B tubulin, alpha 4b 2.10165
KLF8 Kruppel-like factor 8 2.09905
PRMT8 protein arginine methyltransferase 8 2.09795
NKRF NFKB repressing factor 2.0921
DUSP8 dual specificity phosphatase 8 2.0916
OCRL oculocerebrorenal syndrome of Lowe 2.09135
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.0876
SYT1 synaptotagmin I 2.08757
SUMO4 small ubiquitin-like modifier 4 2.0843
PARP3 poly (ADP-ribose) polymerase family, member 3 2.08365
NIT1 nitrilase 1 2.08295
PFKM phosphofructokinase, muscle 2.08105
MAG myelin associated glycoprotein 2.0805
DRC9 dynein regulatory complex subunit 9 2.0752
HMG20B high mobility group 20B 2.07162
PAX9 paired box 9 2.071
DNALI1 dynein, axonemal, light intermediate chain 1 2.0693
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.06337
BARX2 BARX homeobox 2 2.06315
NCALD neurocalcin delta 2.0599
MFN2 mitofusin 2 2.05923
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.05235
HSPB3 heat shock 27kDa protein 3 2.0517
PLAC1 placenta-specific 1 2.04975
RTN1 reticulon 1 2.04953
IRGQ immunity-related GTPase family, Q 2.04943
MORC3 MORC family CW-type zinc finger 3 2.0475
FBXL7 F-box and leucine-rich repeat protein 7 2.0444
ISL1 ISL LIM homeobox 1 2.04385
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.0432
CFAP69 cilia and flagella associated protein 69 2.04315
CDC37 cell division cycle 37 2.04215
EPHA4 EPH receptor A4 2.0358
VCPKMT valosin containing protein lysine (K) methyltransferase 2.0332
AMPD3 adenosine monophosphate deaminase 3 2.03015
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.02835
LCN2 lipocalin 2 2.0275
SPRY4 sprouty homolog 4 (Drosophila) 2.0272
DUS2 dihydrouridine synthase 2 2.02533
SYNJ2BP synaptojanin 2 binding protein 2.0192
FBXO5 F-box protein 5 2.01505
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.0099
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.0096
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.00885
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.00775
ISCA1 iron-sulfur cluster assembly 1 2.00698
TYW2 tRNA wybutosine-synthesizing protein 2 2.00615
ZFP37 ZFP37 zinc finger protein 2.0016
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.00005

decreased expression

Symbol Name Standardized Value
TCTN1 tectonic family member 1 -6.9745
CDC20 cell division cycle 20 -5.5741
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.45365
TM9SF2 transmembrane 9 superfamily member 2 -5.43165
ACAA1 acetyl-CoA acyltransferase 1 -5.28193
TLCD3A TLC domain containing 3A -5.144
LAP3 leucine aminopeptidase 3 -5.0687
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -5.0569
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.89075
PCCB propionyl CoA carboxylase, beta polypeptide -4.84645
PCNA proliferating cell nuclear antigen -4.82295
CCNB1 cyclin B1 -4.68305
TRIB3 tribbles pseudokinase 3 -4.6649
ARID5B AT rich interactive domain 5B (MRF1-like) -4.5819
SCAND1 SCAN domain containing 1 -4.5591
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -4.5503
HAT1 histone acetyltransferase 1 -4.50755
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.46675
GRWD1 glutamate-rich WD repeat containing 1 -4.3654
FBXL12 F-box and leucine-rich repeat protein 12 -4.1192
CCNB2 cyclin B2 -3.9219
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.8279
NGRN neugrin, neurite outgrowth associated -3.76685
C5 complement component 5 -3.6598
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.61585
ZDHHC6 zinc finger, DHHC-type containing 6 -3.6102
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.51025
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.44907
RHEB Ras homolog enriched in brain -3.33538
GNAS GNAS complex locus -3.31623
STAMBP STAM binding protein -3.29485
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.2783
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.222
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.215
KIF2C kinesin family member 2C -3.1238
NUP93 nucleoporin 93kDa -3.06025
LIPG lipase, endothelial -3.0416
FOS FBJ murine osteosarcoma viral oncogene homolog -3.0379
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.0182
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.01687
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.9774
SOAT2 sterol O-acyltransferase 2 -2.97365
ZW10 zw10 kinetochore protein -2.9078
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.89097
GLOD4 glyoxalase domain containing 4 -2.8367
MTFR1 mitochondrial fission regulator 1 -2.72515
ZNF586 zinc finger protein 586 -2.71955
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.6613
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.64565
TXNDC15 thioredoxin domain containing 15 -2.6334
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.6299
GPX7 glutathione peroxidase 7 -2.532
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.5249
ATOX1 antioxidant 1 copper chaperone -2.51535
MALT1 MALT1 paracaspase -2.49253
VAT1 vesicle amine transport 1 -2.4902
NT5DC2 5'-nucleotidase domain containing 2 -2.44945
IGFLR1 IGF-like family receptor 1 -2.4418
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.4344
LRRC41 leucine rich repeat containing 41 -2.39048
KIFBP kinesin family binding protein -2.3851
MZB1 marginal zone B and B1 cell-specific protein -2.37005
HMGA2 high mobility group AT-hook 2 -2.3693
GFUS GDP-L-fucose synthase -2.35962
LOC112694756 uncharaterized LOC112694756 -2.3496
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.33525
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.3303
AKAP8 A kinase (PRKA) anchor protein 8 -2.3205
PRCP prolylcarboxypeptidase (angiotensinase C) -2.29875
GOLT1B golgi transport 1B -2.26315
SQOR sulfide quinone oxidoreductase -2.25505
ENOPH1 enolase-phosphatase 1 -2.24455
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -2.2407
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.23415
CDK4 cyclin-dependent kinase 4 -2.22855
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.22415
WASHC4 WASH complex subunit 4 -2.22338
CAB39 calcium binding protein 39 -2.22285
AATF apoptosis antagonizing transcription factor -2.21705
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.2116
CD180 CD180 molecule -2.21015
IFRD2 interferon-related developmental regulator 2 -2.18917
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.1867
LXN latexin -2.1851
STBD1 starch binding domain 1 -2.1736
SPAG4 sperm associated antigen 4 -2.17125
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.16405
EMD emerin -2.15225
TCERG1 transcription elongation regulator 1 -2.1502
ERCC1 excision repair cross-complementation group 1 -2.1475
CSF3 colony stimulating factor 3 (granulocyte) -2.1457
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.1191
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.11835
PRDX4 peroxiredoxin 4 -2.1023
CRYZ crystallin, zeta (quinone reductase) -2.09165
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound -2.08555
CHMP6 charged multivesicular body protein 6 -2.0819
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.07865
LAGE3 L antigen family, member 3 -2.07135
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.0673
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.0539
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.05155
PSPC1 paraspeckle component 1 -2.04465
FABP1 fatty acid binding protein 1, liver -2.0442
RBM14-RBM4 RBM14-RBM4 readthrough -2.0436
ERCC2 excision repair cross-complementation group 2 -2.0426
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -2.0284
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.02737
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.01555
PTTG1 pituitary tumor-transforming 1 -2.0114
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.0028
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.00185