CRCGN011_HEPG2_24H:H05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminoanthraquinone 2.46 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN011_HEPG2_24H:H05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.01665
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.9466
STK10 serine/threonine kinase 10 4.256
SQOR sulfide quinone oxidoreductase 4.24795
NMU neuromedin U 4.1307
MEST mesoderm specific transcript 3.70345
PMM2 phosphomannomutase 2 3.40515
TENT4A terminal nucleotidyltransferase 4A 3.32025
GSTZ1 glutathione S-transferase zeta 1 3.14185
PLSCR3 phospholipid scramblase 3 3.01627
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.8625
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.8336
SSBP2 single-stranded DNA binding protein 2 2.69012
JADE2 jade family PHD finger 2 2.53575
CHN1 chimerin 1 2.3707
GPATCH8 G patch domain containing 8 2.3636
EPHA3 EPH receptor A3 2.34045
CCNF cyclin F 2.22432
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.1892
MTMR11 myotubularin related protein 11 2.1743
CYCS cytochrome c, somatic 2.1701
TCEAL2 transcription elongation factor A (SII)-like 2 2.0695
CBR4 carbonyl reductase 4 2.0215
GGTLC1 gamma-glutamyltransferase light chain 1 2.0202
GATA2 GATA binding protein 2 2.0055

decreased expression

Symbol Name Standardized Value
CCDC86 coiled-coil domain containing 86 -10.0
LDHD lactate dehydrogenase D -10.0
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.2061
MAPK13 mitogen-activated protein kinase 13 -5.20043
KDM3A lysine (K)-specific demethylase 3A -4.87635
MRPS2 mitochondrial ribosomal protein S2 -4.87075
ZNF586 zinc finger protein 586 -4.8127
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.7771
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.68205
MAP7 microtubule-associated protein 7 -4.53523
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.3256
ADI1 acireductone dioxygenase 1 -4.3021
GRWD1 glutamate-rich WD repeat containing 1 -3.94035
TCTN1 tectonic family member 1 -3.42375
GNAS GNAS complex locus -3.41097
OXA1L oxidase (cytochrome c) assembly 1-like -3.15565
HLA-DMA major histocompatibility complex, class II, DM alpha -3.1504
CCNB2 cyclin B2 -3.05005
TES testin LIM domain protein -2.84343
ZNF134 zinc finger protein 134 -2.7669
PCNA proliferating cell nuclear antigen -2.6794
LZTFL1 leucine zipper transcription factor-like 1 -2.48835
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.46535
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.4635
CMC2 C-x(9)-C motif containing 2 -2.36065
ACAA1 acetyl-CoA acyltransferase 1 -2.3598
GDF15 growth differentiation factor 15 -2.3265
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.29285
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -2.25625
FBXO7 F-box protein 7 -2.1987
FBXL12 F-box and leucine-rich repeat protein 12 -2.1932
TLCD3A TLC domain containing 3A -2.1854
ITGB1BP1 integrin beta 1 binding protein 1 -2.1498
VDAC3 voltage-dependent anion channel 3 -2.14532
TUBB4A tubulin, beta 4A class IVa -2.1294
COQ6 coenzyme Q6 monooxygenase -2.0666
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.03375
GIPC1 GIPC PDZ domain containing family, member 1 -2.0333
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.0251