CRCGN011_HEPG2_24H:H06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminoanthraquinone 1.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

168 genes differentially expressed following the CRCGN011_HEPG2_24H:H06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
E2F2 E2F transcription factor 2 5.14585
BACE2 beta-site APP-cleaving enzyme 2 5.09285
SNAP25 synaptosomal-associated protein, 25kDa 5.0687
CSK c-src tyrosine kinase 4.91515
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.85225
NMU neuromedin U 4.5674
PPARG peroxisome proliferator-activated receptor gamma 4.4464
CARMIL1 capping protein regulator and myosin 1 linker 1 4.2139
LCN2 lipocalin 2 3.7303
MEST mesoderm specific transcript 3.6887
CYCS cytochrome c, somatic 3.6217
CKMT1A creatine kinase, mitochondrial 1A 3.3894
TLR4 toll-like receptor 4 3.35925
TIAM1 T-cell lymphoma invasion and metastasis 1 3.35203
IDE insulin-degrading enzyme 3.32407
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.23715
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.2071
SHB Src homology 2 domain containing adaptor protein B 3.19908
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.15703
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.14455
SPINK5 serine peptidase inhibitor, Kazal type 5 3.1174
VGLL4 vestigial-like family member 4 2.89017
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.79155
KIAA0408 KIAA0408 2.7286
FAM76A family with sequence similarity 76, member A 2.72195
TACR2 tachykinin receptor 2 2.72115
ADTRP androgen-dependent TFPI-regulating protein 2.71045
DYNLT3 dynein, light chain, Tctex-type 3 2.7066
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.6837
WNT3 wingless-type MMTV integration site family, member 3 2.68215
SPIN2A spindlin family, member 2A 2.62105
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.59842
INSM1 insulinoma-associated 1 2.5943
KRT35 keratin 35, type I 2.57035
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.56205
KRT2 keratin 2, type II 2.5278
DIPK1A divergent protein kinase domain 1A 2.52577
PAX6 paired box 6 2.5179
ARSL arylsulfatase L 2.4927
GPATCH8 G patch domain containing 8 2.489
USH2A Usher syndrome 2A (autosomal recessive, mild) 2.4745
FGF22 fibroblast growth factor 22 2.47035
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.4683
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.43985
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.4352
ZNF507 zinc finger protein 507 2.39035
GRM6 glutamate receptor, metabotropic 6 2.38605
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.3814
NOL10 nucleolar protein 10 2.37095
PKD2L2 polycystic kidney disease 2-like 2 2.366
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.36495
MAB21L1 mab-21-like 1 (C. elegans) 2.36055
DHDDS dehydrodolichyl diphosphate synthase 2.3557
PDE7B phosphodiesterase 7B 2.34675
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.34375
CATSPERB catsper channel auxiliary subunit beta 2.3411
PLA2G2E phospholipase A2, group IIE 2.3348
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.33065
TAS2R4 taste receptor, type 2, member 4 2.32265
CRELD2 cysteine-rich with EGF-like domains 2 2.32035
COQ8A coenzyme Q8A 2.31635
MYH15 myosin, heavy chain 15 2.3137
PGLYRP4 peptidoglycan recognition protein 4 2.31175
EDN1 endothelin 1 2.30525
TMEM254 transmembrane protein 254 2.29485
SSTR2 somatostatin receptor 2 2.28625
CCL27 chemokine (C-C motif) ligand 27 2.2797
ANO2 anoctamin 2, calcium activated chloride channel 2.2789
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 2.2763
STMN2 stathmin 2 2.24358
LALBA lactalbumin, alpha- 2.2298
CA4 carbonic anhydrase IV 2.22918
CARD14 caspase recruitment domain family, member 14 2.22213
LORICRIN loricrin cornified envelope precursor protein 2.22005
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 2.2088
HOXA4 homeobox A4 2.2064
PCDHA9 protocadherin alpha 9 2.2051
GPX5 glutathione peroxidase 5 2.1962
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.18525
C18ORF25 chromosome 18 open reading frame 25 2.1842
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.17895
KRTAP2-3 keratin associated protein 2-3 2.17795
ADAM20 ADAM metallopeptidase domain 20 2.17405
NPVF neuropeptide VF precursor 2.17095
EN2 engrailed homeobox 2 2.16715
A4GNT alpha-1,4-N-acetylglucosaminyltransferase 2.1554
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 2.15372
CRYGA crystallin, gamma A 2.14795
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.1477
LAMB4 laminin, beta 4 2.1428
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.1301
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 2.12125
ARSF arylsulfatase F 2.11265
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.11245
CCDC28A coiled-coil domain containing 28A 2.10935
ANKRD34C ankyrin repeat domain 34C 2.10485
NHLH2 nescient helix loop helix 2 2.10427
TRIM46 tripartite motif containing 46 2.1026
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.10085
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.1007
BRS3 bombesin-like receptor 3 2.10015
ANKEF1 ankyrin repeat and EF-hand domain containing 1 2.09985
JPH2 junctophilin 2 2.09865
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.09575
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.0954
SH2D3C SH2 domain containing 3C 2.0897
MSH4 mutS homolog 4 2.0874
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) 2.0789
CIDEA cell death-inducing DFFA-like effector a 2.07725
PRDM9 PR domain containing 9 2.07715
NEUROG1 neurogenin 1 2.06885
PLSCR3 phospholipid scramblase 3 2.06765
OR10H3 olfactory receptor, family 10, subfamily H, member 3 2.06525
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.06525
TCP10L t-complex 10-like 2.0652
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 2.06235
TMEM151B transmembrane protein 151B 2.05985
LHCGR luteinizing hormone/choriogonadotropin receptor 2.05945
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 2.0577
IFNA7 interferon, alpha 7 2.0551
MYH4 myosin, heavy chain 4, skeletal muscle 2.0543
RTN1 reticulon 1 2.05002
ZNF343 zinc finger protein 343 2.0462
MEIS2 Meis homeobox 2 2.04145
LAMA4 laminin, alpha 4 2.03935
KLK5 kallikrein-related peptidase 5 2.03825
TRHR thyrotropin-releasing hormone receptor 2.03615
PAPOLB poly(A) polymerase beta (testis specific) 2.0354
ZNF219 zinc finger protein 219 2.0302
AQP8 aquaporin 8 2.0279
PLAGL1 pleiomorphic adenoma gene-like 1 2.02735
CD207 CD207 molecule, langerin 2.0244
ACAD10 acyl-CoA dehydrogenase family, member 10 2.02345
ADAM7 ADAM metallopeptidase domain 7 2.02273
DSG1 desmoglein 1 2.02155
NEUROD2 neuronal differentiation 2 2.0158
GPR50 G protein-coupled receptor 50 2.01525
ARL4C ADP-ribosylation factor-like 4C 2.01513
LOC100652777 group 10 secretory phospholipase A2-like 2.0137
MCHR1 melanin-concentrating hormone receptor 1 2.0136
PBOV1 prostate and breast cancer overexpressed 1 2.013
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2.0113
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.01025
MAGIX MAGI family member, X-linked 2.0084
KLF8 Kruppel-like factor 8 2.00495
OPRPN opiorphin prepropeptide 2.00045
KRT32 keratin 32, type I 2.0002

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -5.70855
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0854
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.39915
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.6706
GFUS GDP-L-fucose synthase -2.9512
HEATR1 HEAT repeat containing 1 -2.92702
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.7489
YME1L1 YME1-like 1 ATPase -2.57892
RCL1 RNA terminal phosphate cyclase-like 1 -2.40995
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.31247
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.24975
MSL1 male-specific lethal 1 homolog (Drosophila) -2.15655
ADSS2 adenylosuccinate synthase 2 -2.15265
YTHDC1 YTH domain containing 1 -2.13325
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.12095
GGNBP2 gametogenetin binding protein 2 -2.0893
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.0603
DUSP14 dual specificity phosphatase 14 -2.04645
MNT MAX network transcriptional repressor -2.01235
KRI1 KRI1 homolog (S. cerevisiae) -2.0119