CRCGN011_HEPG2_24H:H08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description doxylamine 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN011_HEPG2_24H:H08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 9.09925
STIMATE STIM activating enhancer 8.94975
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.44215
AMDHD2 amidohydrolase domain containing 2 5.31805
E2F2 E2F transcription factor 2 5.2772
PLS1 plastin 1 4.9293
UBQLN2 ubiquilin 2 4.5246
ADRB2 adrenoceptor beta 2, surface 4.4721
PRR15L proline rich 15-like 4.12575
ATP11B ATPase, class VI, type 11B 3.82225
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.7324
CYCS cytochrome c, somatic 3.43875
TIAM1 T-cell lymphoma invasion and metastasis 1 3.13828
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.9818
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.91485
JADE2 jade family PHD finger 2 2.7196
DIPK1A divergent protein kinase domain 1A 2.62507
SST somatostatin 2.54165
EPHA3 EPH receptor A3 2.52573
PLSCR3 phospholipid scramblase 3 2.49043
LDOC1 leucine zipper, down-regulated in cancer 1 2.4555
CGRRF1 cell growth regulator with ring finger domain 1 2.432
VGLL4 vestigial-like family member 4 2.42515
TRMT61B tRNA methyltransferase 61B 2.3668
TSLIG3A tRNA splicing ligase complex subunit 3A 2.3362
APOC3 apolipoprotein C-III 2.17725
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.1278
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.1205
IRF9 interferon regulatory factor 9 2.08465
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.0563
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.05387
APH1B APH1B gamma secretase subunit 2.0377

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCDC86 coiled-coil domain containing 86 -5.9223
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.31665
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.1329
LOC124907782 dual specificity protein phosphatase 22 -5.08395
TRIB3 tribbles pseudokinase 3 -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8422
KDM3A lysine (K)-specific demethylase 3A -4.74675
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.89038
GNAS GNAS complex locus -3.56579
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.5015
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.25798
TCTN1 tectonic family member 1 -3.21745
HEATR1 HEAT repeat containing 1 -3.20473
TLCD3A TLC domain containing 3A -3.17165
PCNA proliferating cell nuclear antigen -2.9806
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.9409
FOS FBJ murine osteosarcoma viral oncogene homolog -2.9185
JAK1 Janus kinase 1 -2.832
TRAP1 TNF receptor-associated protein 1 -2.7369
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -2.72922
FCHO1 FCH domain only 1 -2.65595
LZTR1 leucine-zipper-like transcription regulator 1 -2.5217
GDF15 growth differentiation factor 15 -2.515
PRAME preferentially expressed antigen in melanoma -2.4987
SORD sorbitol dehydrogenase -2.49258
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.452
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -2.44655
TSFM Ts translation elongation factor, mitochondrial -2.38173
NAMPT nicotinamide phosphoribosyltransferase -2.32562
STAT5A signal transducer and activator of transcription 5A -2.26895
CHI3L2 chitinase 3-like 2 -2.25235
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.2455
MACIR macrophage immunometabolism regulator -2.22515
THAP7 THAP domain containing 7 -2.21915
FAR2 fatty acyl CoA reductase 2 -2.145
MACROD1 MACRO domain containing 1 -2.13015
IMMT inner membrane protein, mitochondrial -2.1096
SETX senataxin -2.10932
GCC1 GRIP and coiled-coil domain containing 1 -2.1064
CAB39 calcium binding protein 39 -2.09375
GHR growth hormone receptor -2.085
CDKN2A cyclin-dependent kinase inhibitor 2A -2.05183