CRCGN011_HEPG2_24H:H10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description doxylamine 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

97 genes differentially expressed following the CRCGN011_HEPG2_24H:H10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 9.2279
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.1479
TIAM1 T-cell lymphoma invasion and metastasis 1 6.48845
GSTZ1 glutathione S-transferase zeta 1 6.1363
CXCL2 chemokine (C-X-C motif) ligand 2 5.3271
UBQLN2 ubiquilin 2 5.17795
PPARG peroxisome proliferator-activated receptor gamma 4.77435
AMDHD2 amidohydrolase domain containing 2 4.69085
NMU neuromedin U 4.4705
C2CD2 C2 calcium-dependent domain containing 2 4.38725
BACE2 beta-site APP-cleaving enzyme 2 4.3855
STK10 serine/threonine kinase 10 4.24945
PRR15L proline rich 15-like 4.1429
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.11525
TCEA2 transcription elongation factor A (SII), 2 3.93375
INTS3 integrator complex subunit 3 3.90225
SSBP2 single-stranded DNA binding protein 2 3.73665
PLSCR3 phospholipid scramblase 3 3.73368
MAP7 microtubule-associated protein 7 3.68373
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.61955
VAV3 vav 3 guanine nucleotide exchange factor 3.52285
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.03375
MICALL1 MICAL-like 1 2.9064
RAB21 RAB21, member RAS oncogene family 2.8139
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 2.7545
HOOK2 hook microtubule-tethering protein 2 2.7188
EDN1 endothelin 1 2.59795
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.59645
TMEM109 transmembrane protein 109 2.53475
PAX6 paired box 6 2.30125
LMO3 LIM domain only 3 (rhombotin-like 2) 2.2635
TPH1 tryptophan hydroxylase 1 2.25295
PNLIPRP2 pancreatic lipase-related protein 2 2.2362
PDZRN3 PDZ domain containing ring finger 3 2.1885
PTPN21 protein tyrosine phosphatase, non-receptor type 21 2.15317
GMFG glia maturation factor, gamma 2.1422
CPA1 carboxypeptidase A1 (pancreatic) 2.1421
CLDN7 claudin 7 2.13975
CELA2A chymotrypsin-like elastase family, member 2A 2.1316
CELA2B chymotrypsin-like elastase family, member 2B 2.1242
TESK1 testis-specific kinase 1 2.1203
RNF103 ring finger protein 103 2.11405
CPA2 carboxypeptidase A2 (pancreatic) 2.10825
CLIC3 chloride intracellular channel 3 2.08205
ANKRD46 ankyrin repeat domain 46 2.07175
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.00805

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.64195
TRIB3 tribbles pseudokinase 3 -5.14015
GDF15 growth differentiation factor 15 -5.0
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.9719
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.9619
CHMP4B charged multivesicular body protein 4B -4.6798
VAT1 vesicle amine transport 1 -4.45425
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.9299
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.71146
MAPK13 mitogen-activated protein kinase 13 -3.59923
WASHC4 WASH complex subunit 4 -3.32783
ADI1 acireductone dioxygenase 1 -3.2956
PCNA proliferating cell nuclear antigen -3.1873
HEATR1 HEAT repeat containing 1 -3.05142
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.988
OXA1L oxidase (cytochrome c) assembly 1-like -2.9806
HLA-DMA major histocompatibility complex, class II, DM alpha -2.93045
PRPF4 pre-mRNA processing factor 4 -2.78807
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.61845
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.61505
ZNF134 zinc finger protein 134 -2.5241
ZNF587 zinc finger protein 587 -2.503
ZNF671 zinc finger protein 671 -2.4217
ZNF304 zinc finger protein 304 -2.38765
MEAF6 MYST/Esa1-associated factor 6 -2.33285
ZNF587B zinc finger protein 587B -2.3193
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.3061
UGCG UDP-glucose ceramide glucosyltransferase -2.29235
RHOB ras homolog family member B -2.2625
ZNF211 zinc finger protein 211 -2.242
ARL4D ADP-ribosylation factor-like 4D -2.24185
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.23995
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.21465
ZNF551 zinc finger protein 551 -2.19665
NOCT nocturnin -2.19495
FCGRT Fc fragment of IgG, receptor, transporter, alpha -2.18945
LOC128125814 uncharacterized LOC128125814 -2.1758
STX18 syntaxin 18 -2.1344
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.12795
GAS6 growth arrest-specific 6 -2.12635
ITGB1BP1 integrin beta 1 binding protein 1 -2.10707
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.08365
NEFH neurofilament, heavy polypeptide -2.07767
EMP3 epithelial membrane protein 3 -2.0628
ASRGL1 asparaginase like 1 -2.06125
ZNF544 zinc finger protein 544 -2.04275
ZNF761 zinc finger protein 761 -2.0425
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -2.02865
RNF2 ring finger protein 2 -2.01545
OSBP oxysterol binding protein -2.01393
PRSS21 protease, serine, 21 (testisin) -2.0062