CRCGN011_HEPG2_24H:H12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description doxylamine 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

155 genes differentially expressed following the CRCGN011_HEPG2_24H:H12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 9.35135
UBQLN2 ubiquilin 2 5.40425
SQOR sulfide quinone oxidoreductase 5.0912
LCN2 lipocalin 2 5.0
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.9771
CARMIL1 capping protein regulator and myosin 1 linker 1 4.8611
MCOLN1 mucolipin 1 4.7971
CHMP6 charged multivesicular body protein 6 4.6742
STK10 serine/threonine kinase 10 4.4478
HYOU1 hypoxia up-regulated 1 4.3945
GSTZ1 glutathione S-transferase zeta 1 4.2817
PLS1 plastin 1 4.21855
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.2182
PRKCH protein kinase C, eta 4.016
CYCS cytochrome c, somatic 3.73485
GPER1 G protein-coupled estrogen receptor 1 3.51863
KIF5C kinesin family member 5C 3.49253
VAV3 vav 3 guanine nucleotide exchange factor 3.47135
ABHD6 abhydrolase domain containing 6 3.28805
SPC25 SPC25, NDC80 kinetochore complex component 3.2581
PFKL phosphofructokinase, liver 3.22743
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.94493
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.8114
JADE2 jade family PHD finger 2 2.78645
KLHL9 kelch-like family member 9 2.77905
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.7591
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.747
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.74265
APRT adenine phosphoribosyltransferase 2.6882
DIPK1A divergent protein kinase domain 1A 2.67855
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.67202
CHN1 chimerin 1 2.56385
ILF2 interleukin enhancer binding factor 2 2.53095
PNPLA6 patatin-like phospholipase domain containing 6 2.5259
ATP11B ATPase, class VI, type 11B 2.5007
BBLN bublin coiled coil protein 2.49005
COQ8A coenzyme Q8A 2.48155
ZNF557 zinc finger protein 557 2.4801
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.45275
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.4432
FBXL6 F-box and leucine-rich repeat protein 6 2.43975
CNOT1 CCR4-NOT transcription complex, subunit 1 2.41262
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.37657
RPL8 ribosomal protein L8 2.3722
NUP133 nucleoporin 133kDa 2.3624
RNF43 ring finger protein 43 2.3314
FLOT2 flotillin 2 2.31647
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.31045
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.30375
KDM5C lysine (K)-specific demethylase 5C 2.28455
APP amyloid beta (A4) precursor protein 2.25073
GIPC2 GIPC PDZ domain containing family, member 2 2.24675
USP21 ubiquitin specific peptidase 21 2.2409
WASF3 WAS protein family, member 3 2.23975
TSPAN14 tetraspanin 14 2.23605
MMP10 matrix metallopeptidase 10 2.2208
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 2.21755
WDTC1 WD and tetratricopeptide repeats 1 2.2137
NDC80 NDC80 kinetochore complex component 2.1984
CTAG2 cancer/testis antigen 2 2.19416
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.1898
EDN1 endothelin 1 2.18815
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 2.17753
STC1 stanniocalcin 1 2.16595
FKRP fukutin related protein 2.1524
CD5 CD5 molecule 2.14775
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.14525
CIB2 calcium and integrin binding family member 2 2.14332
PGLS 6-phosphogluconolactonase 2.12398
ACVRL1 activin A receptor type II-like 1 2.12025
GPR176 G protein-coupled receptor 176 2.11425
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.1068
IL23A interleukin 23, alpha subunit p19 2.1065
USB1 U6 snRNA biogenesis 1 2.10525
CD7 CD7 molecule 2.08015
EMCN endomucin 2.0702
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.05925
AP5M1 adaptor-related protein complex 5, mu 1 subunit 2.0538
CENPQ centromere protein Q 2.0491
ACAA2 acetyl-CoA acyltransferase 2 2.0449
DDB1 damage-specific DNA binding protein 1, 127kDa 2.0437
RLIM ring finger protein, LIM domain interacting 2.04025
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.0335
ZBTB5 zinc finger and BTB domain containing 5 2.02545
TLN1 talin 1 2.01965
LIME1 Lck interacting transmembrane adaptor 1 2.009
ZFP36 ZFP36 ring finger protein 2.0076

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -8.45585
CCNB2 cyclin B2 -6.6854
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
COG7 component of oligomeric golgi complex 7 -5.0
KDM3A lysine (K)-specific demethylase 3A -4.97835
C2CD5 C2 calcium-dependent domain containing 5 -4.9636
LDHD lactate dehydrogenase D -4.7459
CCNB1 cyclin B1 -4.62515
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.40045
MAP7 microtubule-associated protein 7 -4.06655
GNAS GNAS complex locus -3.39392
SLC35F2 solute carrier family 35, member F2 -3.353
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.23828
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -3.18445
PCNA proliferating cell nuclear antigen -3.17715
NPIPA6 nuclear pore complex interacting protein family, member A6 -3.0191
HMOX2 heme oxygenase 2 -2.94217
DERA deoxyribose-phosphate aldolase (putative) -2.8936
WASHC4 WASH complex subunit 4 -2.8358
PROS1 protein S (alpha) -2.82885
BFAR bifunctional apoptosis regulator -2.8161
METTL22 methyltransferase like 22 -2.7271
VDAC1 voltage-dependent anion channel 1 -2.67672
HEATR1 HEAT repeat containing 1 -2.6732
NUP62 nucleoporin 62kDa -2.64873
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.63735
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.6331
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.55385
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.53465
MARF1 meiosis regulator and mRNA stability factor 1 -2.5275
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.52253
MRPL17 mitochondrial ribosomal protein L17 -2.50225
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.49505
CASP8AP2 caspase 8 associated protein 2 -2.47765
ZNF500 zinc finger protein 500 -2.46403
SNX3 sorting nexin 3 -2.4526
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.44535
DUSP14 dual specificity phosphatase 14 -2.4011
UNKL unkempt family zinc finger-like -2.3907
PARN poly(A)-specific ribonuclease -2.37765
MDN1 MDN1, midasin homolog (yeast) -2.35125
RAD54L RAD54-like (S. cerevisiae) -2.33065
HIRIP3 HIRA interacting protein 3 -2.3014
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.2852
FNBP4 formin binding protein 4 -2.23865
IRF7 interferon regulatory factor 7 -2.2074
ATAD2B ATPase family, AAA domain containing 2B -2.1868
MORC2 MORC family CW-type zinc finger 2 -2.1564
E4F1 E4F transcription factor 1 -2.15525
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.154
SNUPN snurportin 1 -2.1141
CDCA8 cell division cycle associated 8 -2.10305
MPHOSPH8 M-phase phosphoprotein 8 -2.0933
MSL2 male-specific lethal 2 homolog (Drosophila) -2.08325
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.0798
AKIP1 A kinase (PRKA) interacting protein 1 -2.06855
ZNF263 zinc finger protein 263 -2.0638
PCTP phosphatidylcholine transfer protein -2.06285
TASOR2 transcription activation suppressor family member 2 -2.0616
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.0472
VEZT vezatin, adherens junctions transmembrane protein -2.0386
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.0337
ITGB1BP1 integrin beta 1 binding protein 1 -2.0322
ERGIC2 ERGIC and golgi 2 -2.028
TALDO1 transaldolase 1 -2.0262
PIGK phosphatidylinositol glycan anchor biosynthesis, class K -2.026
NPY neuropeptide Y -2.00895