CRCGN011_HEPG2_24H:H14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description malathion 10.59 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

185 genes differentially expressed following the CRCGN011_HEPG2_24H:H14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 10.0
BZW2 basic leucine zipper and W2 domains 2 6.10735
UBQLN2 ubiquilin 2 5.59025
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.4873
JADE2 jade family PHD finger 2 5.47547
TESK1 testis-specific kinase 1 5.41895
CHEK2 checkpoint kinase 2 5.30543
ADRB2 adrenoceptor beta 2, surface 5.2079
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8284
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.0902
ABHD4 abhydrolase domain containing 4 4.0845
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.9102
ABHD6 abhydrolase domain containing 6 3.71487
SSBP2 single-stranded DNA binding protein 2 3.58923
ADAT1 adenosine deaminase, tRNA-specific 1 3.54855
MAST2 microtubule associated serine/threonine kinase 2 3.50613
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.37365
VGLL4 vestigial-like family member 4 3.34405
TLR4 toll-like receptor 4 3.249
MEST mesoderm specific transcript 3.20475
HOOK2 hook microtubule-tethering protein 2 3.12403
DYNLT3 dynein, light chain, Tctex-type 3 2.93855
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.8339
CDC123 cell division cycle 123 2.7571
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.70695
PES1 pescadillo ribosomal biogenesis factor 1 2.6941
ZHX2 zinc fingers and homeoboxes 2 2.6798
CREB3L4 cAMP responsive element binding protein 3-like 4 2.6678
PRODH proline dehydrogenase (oxidase) 1 2.65885
MMP7 matrix metallopeptidase 7 2.62315
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.5775
MAN2A1 mannosidase, alpha, class 2A, member 1 2.5692
PFN2 profilin 2 2.5497
PER3 period circadian clock 3 2.54065
S100A2 S100 calcium binding protein A2 2.5389
CDC37L1 cell division cycle 37-like 1 2.5366
UFSP2 UFM1-specific peptidase 2 2.51265
PRR15L proline rich 15-like 2.4874
TIAM1 T-cell lymphoma invasion and metastasis 1 2.48725
FZD7 frizzled class receptor 7 2.48555
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.39913
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.3751
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.37405
HOOK1 hook microtubule-tethering protein 1 2.37255
HSPA14 heat shock 70kDa protein 14 2.37185
NOSIP nitric oxide synthase interacting protein 2.36385
ZNF232 zinc finger protein 232 2.35905
SEPHS1 selenophosphate synthetase 1 2.33973
LAMB3 laminin, beta 3 2.3202
RGPD1 RANBP2-like and GRIP domain containing 1 2.3134
IDO1 indoleamine 2,3-dioxygenase 1 2.2917
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.29152
CELA3B chymotrypsin-like elastase family, member 3B 2.2904
SLC12A9 solute carrier family 12, member 9 2.28755
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.2731
SYNGR3 synaptogyrin 3 2.2561
ZMYM2 zinc finger, MYM-type 2 2.25417
ZNF165 zinc finger protein 165 2.24655
CYB561 cytochrome b561 2.24454
INTS6 integrator complex subunit 6 2.23725
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.23415
ASF1A anti-silencing function 1A histone chaperone 2.23217
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.21615
CRELD2 cysteine-rich with EGF-like domains 2 2.2124
FPGS folylpolyglutamate synthase 2.1969
SKIC8 SKI8 subunit of superkiller complex 2.19423
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.1866
KIN Kin17 DNA and RNA binding protein 2.17095
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.16355
TPD52L1 tumor protein D52-like 1 2.13715
PRPF18 pre-mRNA processing factor 18 2.12845
CRABP1 cellular retinoic acid binding protein 1 2.11385
CDCP1 CUB domain containing protein 1 2.1019
TUBA4A tubulin, alpha 4a 2.0971
SOX11 SRY (sex determining region Y)-box 11 2.08535
SNX24 sorting nexin 24 2.0827
LIAS lipoic acid synthetase 2.0824
NDN necdin, melanoma antigen (MAGE) family member 2.04675
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 2.0446
UBXN7 UBX domain protein 7 2.0401
NKX2-2 NK2 homeobox 2 2.03485
SLC22A17 solute carrier family 22, member 17 2.02955
IL17RA interleukin 17 receptor A 2.0257
OSBPL10 oxysterol binding protein-like 10 2.0175

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -10.0
LDHD lactate dehydrogenase D -10.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -9.2329
ADI1 acireductone dioxygenase 1 -7.9883
HEATR1 HEAT repeat containing 1 -6.092
ZDHHC6 zinc finger, DHHC-type containing 6 -5.73065
NUP85 nucleoporin 85kDa -5.31885
THAP11 THAP domain containing 11 -5.2728
COG2 component of oligomeric golgi complex 2 -5.224
KDM3A lysine (K)-specific demethylase 3A -5.12845
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.9753
CCDC86 coiled-coil domain containing 86 -4.97235
DNM1L dynamin 1-like -4.90535
CCNB1 cyclin B1 -4.7964
RPIA ribose 5-phosphate isomerase A -4.70785
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.66345
GOLT1B golgi transport 1B -4.45535
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.29875
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.13732
CCNB2 cyclin B2 -3.81075
PCNA proliferating cell nuclear antigen -3.709
NRIP1 nuclear receptor interacting protein 1 -3.645
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.59842
RANBP10 RAN binding protein 10 -3.56255
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -3.47227
KLK11 kallikrein-related peptidase 11 -3.4514
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.0936
MRPS7 mitochondrial ribosomal protein S7 -2.8146
SNX11 sorting nexin 11 -2.77072
PCTP phosphatidylcholine transfer protein -2.7583
KCTD2 potassium channel tetramerization domain containing 2 -2.73552
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.7099
LRRC59 leucine rich repeat containing 59 -2.6517
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.5964
RCOR3 REST corepressor 3 -2.59395
XPO7 exportin 7 -2.58822
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -2.5207
RFPL2 ret finger protein-like 2 -2.45245
YOD1 YOD1 deubiquitinase -2.4374
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.43725
BAALC brain and acute leukemia, cytoplasmic -2.42405
TYR tyrosinase -2.42165
ALX1 ALX homeobox 1 -2.4204
XK X-linked Kx blood group -2.41735
FDXR ferredoxin reductase -2.41625
GRB2 growth factor receptor-bound protein 2 -2.4101
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I -2.38185
RGS2 regulator of G-protein signaling 2 -2.38105
CD58 CD58 molecule -2.37865
CDC23 cell division cycle 23 -2.3718
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.3502
ACTA2 actin, alpha 2, smooth muscle, aorta -2.3427
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -2.33345
KLHDC8A kelch domain containing 8A -2.3227
ZBTB39 zinc finger and BTB domain containing 39 -2.3212
POU4F1 POU class 4 homeobox 1 -2.3172
EXT1 exostosin glycosyltransferase 1 -2.3056
RECQL RecQ helicase-like -2.30297
MXI1 MAX interactor 1, dimerization protein -2.29735
SATB2 SATB homeobox 2 -2.2947
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.2771
PTDSS2 phosphatidylserine synthase 2 -2.2764
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.27395
HLA-DMA major histocompatibility complex, class II, DM alpha -2.2562
ZNF816 zinc finger protein 816 -2.2449
EMP3 epithelial membrane protein 3 -2.23405
PGLYRP4 peptidoglycan recognition protein 4 -2.218
CGGBP1 CGG triplet repeat binding protein 1 -2.21305
EPCIP exosomal polycystin 1 interacting protein -2.21135
WDR45B WD repeat domain 45B -2.2097
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 -2.1934
TSPAN7 tetraspanin 7 -2.1868
INKA2 inka box actin regulator 2 -2.18325
BTN2A1 butyrophilin, subfamily 2, member A1 -2.17542
SUMO4 small ubiquitin-like modifier 4 -2.17295
TMC5 transmembrane channel-like 5 -2.15835
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.13975
BMAL2 basic helix-loop-helix ARNT like 2 -2.1248
SLURP1 secreted LY6/PLAUR domain containing 1 -2.10965
FERMT1 fermitin family member 1 -2.10745
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 -2.1026
EN2 engrailed homeobox 2 -2.0992
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 -2.09735
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.09625
AKAP12 A kinase (PRKA) anchor protein 12 -2.09565
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.0919
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) -2.0905
PADI1 peptidyl arginine deiminase, type I -2.0804
CALCOCO2 calcium binding and coiled-coil domain 2 -2.056
GLO1 glyoxalase I -2.0507
KLHL3 kelch-like family member 3 -2.04995
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.0446
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.04
HPCAL1 hippocalcin-like 1 -2.03903
NXPE4 neurexophilin and PC-esterase domain family, member 4 -2.03575
ATL2 atlastin GTPase 2 -2.02995
MRPL58 mitochondrial ribosomal protein L58 -2.0193
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.01125
SCML2 sex comb on midleg-like 2 (Drosophila) -2.0104
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -2.0076