CRCGN011_HEPG2_24H:H17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description malathion 1.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN011_HEPG2_24H:H17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 5.98285
MNAT1 MNAT CDK-activating kinase assembly factor 1 5.3934
INTS3 integrator complex subunit 3 5.20065
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.9825
TLR4 toll-like receptor 4 4.94215
PPARG peroxisome proliferator-activated receptor gamma 4.8821
LAGE3 L antigen family, member 3 4.87095
STIMATE STIM activating enhancer 4.8488
ADRB2 adrenoceptor beta 2, surface 4.8384
CSK c-src tyrosine kinase 4.78885
PHKG2 phosphorylase kinase, gamma 2 (testis) 4.28435
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.114
CCL2 chemokine (C-C motif) ligand 2 3.9572
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.77992
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.7363
SSBP2 single-stranded DNA binding protein 2 2.97253
NMU neuromedin U 2.8998
RXYLT1 ribitol xylosyltransferase 1 2.88338
TEX10 testis expressed 10 2.8057
EVI2A ecotropic viral integration site 2A 2.6762
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.5513
ZNF589 zinc finger protein 589 2.44502
TLN1 talin 1 2.4357
BIRC2 baculoviral IAP repeat containing 2 2.4152
CHN1 chimerin 1 2.40055
EXOC2 exocyst complex component 2 2.39925
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.3597
C1QTNF3 C1q and tumor necrosis factor related protein 3 2.29235
LRRC49 leucine rich repeat containing 49 2.27835
PLPPR1 phospholipid phosphatase related 1 2.2417
WIF1 WNT inhibitory factor 1 2.23445
RAB26 RAB26, member RAS oncogene family 2.21305
NME7 NME/NM23 family member 7 2.2096
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.19472
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.16185
POLM polymerase (DNA directed), mu 2.12175
DUSP3 dual specificity phosphatase 3 2.10895
EPS8L2 EPS8-like 2 2.1069
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.09335
WASF1 WAS protein family, member 1 2.08805
TMEM47 transmembrane protein 47 2.0694
KCTD5 potassium channel tetramerization domain containing 5 2.05085
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.01828
HMOX1 heme oxygenase 1 2.0133
OMG oligodendrocyte myelin glycoprotein 2.0024

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -8.9646
SCAND1 SCAN domain containing 1 -5.5842
UGDH UDP-glucose 6-dehydrogenase -5.2085
ZDHHC6 zinc finger, DHHC-type containing 6 -5.20615
CD320 CD320 molecule -5.1796
PECR peroxisomal trans-2-enoyl-CoA reductase -5.0807
KDM3A lysine (K)-specific demethylase 3A -5.02695
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.9366
LDHD lactate dehydrogenase D -4.61705
CHMP4B charged multivesicular body protein 4B -4.55123
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.46035
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.36725
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.322
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.2042
MAPK13 mitogen-activated protein kinase 13 -3.97827
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.97095
PEG10 paternally expressed 10 -3.93397
EIF5 eukaryotic translation initiation factor 5 -3.70159
YME1L1 YME1-like 1 ATPase -3.67708
ADI1 acireductone dioxygenase 1 -3.53235
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.25565
CCNB2 cyclin B2 -3.13505
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.10595
FASTKD5 FAST kinase domains 5 -2.95315
VDAC1 voltage-dependent anion channel 1 -2.94533
HEATR1 HEAT repeat containing 1 -2.76837
GRN granulin -2.68883
ACO2 aconitase 2, mitochondrial -2.6787
CHIC2 cysteine-rich hydrophobic domain 2 -2.6
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.56175
PARM1 prostate androgen-regulated mucin-like protein 1 -2.46015
NID2 nidogen 2 (osteonidogen) -2.3615
STRA6 stimulated by retinoic acid 6 -2.32945
HMG20B high mobility group 20B -2.3157
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.3122
PRPF4 pre-mRNA processing factor 4 -2.30395
LGALS9C lectin, galactoside-binding, soluble, 9C -2.2294
SLC49A3 solute carrier family 49 member 3 -2.1913
BTG1 B-cell translocation gene 1, anti-proliferative -2.1781
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.1773
LOC124906748 beta-defensin 4A -2.1502
ACAA1 acetyl-CoA acyltransferase 1 -2.13005
KIF14 kinesin family member 14 -2.1286
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.12315
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.12125
VWA1 von Willebrand factor A domain containing 1 -2.09395
JOSD1 Josephin domain containing 1 -2.0799
TLCD3A TLC domain containing 3A -2.07415
ZNF506 zinc finger protein 506 -2.05355
SPRY4 sprouty homolog 4 (Drosophila) -2.0334
DUSP5 dual specificity phosphatase 5 -2.0233