CRCGN011_HEPG2_24H:H18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description malathion 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN011_HEPG2_24H:H18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 4.787
EAPP E2F-associated phosphoprotein 4.5936
TLR4 toll-like receptor 4 4.3818
CHN1 chimerin 1 4.33
MAMLD1 mastermind-like domain containing 1 4.14695
CXCL2 chemokine (C-X-C motif) ligand 2 4.13995
LCN2 lipocalin 2 4.06615
HDGFL3 HDGF like 3 3.94392
ABHD6 abhydrolase domain containing 6 3.63733
CYCS cytochrome c, somatic 3.38355
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.1206
GARRE1 granule associated Rac and RHOG effector 1 2.9337
TREM1 triggering receptor expressed on myeloid cells 1 2.4646
GPC1 glypican 1 2.40447
ARMC6 armadillo repeat containing 6 2.33575
BPHL biphenyl hydrolase-like (serine hydrolase) 2.24015
PRKCD protein kinase C, delta 2.2228
PGM3 phosphoglucomutase 3 2.17995
COL11A1 collagen, type XI, alpha 1 2.13132
SCYL3 SCY1-like 3 (S. cerevisiae) 2.1275
ZNF85 zinc finger protein 85 2.1143
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.11005
MAP9 microtubule-associated protein 9 2.031

decreased expression

Symbol Name Standardized Value
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -7.73625
ZDHHC6 zinc finger, DHHC-type containing 6 -5.325
LDHD lactate dehydrogenase D -5.25395
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.0737
GDF15 growth differentiation factor 15 -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.86735
SLC35F2 solute carrier family 35, member F2 -3.95225
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.8188
SPAG4 sperm associated antigen 4 -3.5163
CDC25B cell division cycle 25B -3.5113
NGRN neugrin, neurite outgrowth associated -3.48775
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.37315
TLCD3A TLC domain containing 3A -3.14675
RGS2 regulator of G-protein signaling 2 -2.9787
RFC2 replication factor C (activator 1) 2, 40kDa -2.5111
TGFB3 transforming growth factor, beta 3 -2.33015
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.30365
ANXA10 annexin A10 -2.2524
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit -2.1287
JMJD7 jumonji domain containing 7 -2.12205
ACTL7A actin-like 7A -2.06075
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.05785
ZNHIT1 zinc finger, HIT-type containing 1 -2.02715
MTA1 metastasis associated 1 -2.01315
IL10RA interleukin 10 receptor, alpha -2.0099
NPDC1 neural proliferation, differentiation and control, 1 -2.0045