CRCGN011_HEPG2_24H:H20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triamcinolone 10.04 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN011_HEPG2_24H:H20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.7191
UBQLN2 ubiquilin 2 5.2647
C2CD2 C2 calcium-dependent domain containing 2 5.2198
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.84425
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.83395
MAGEA6 melanoma antigen family A6 3.7756
GSTZ1 glutathione S-transferase zeta 1 3.7485
TLR4 toll-like receptor 4 3.42025
CREB1 cAMP responsive element binding protein 1 3.36208
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.35745
CRTAP cartilage associated protein 3.3547
TRAK2 trafficking protein, kinesin binding 2 3.23355
DDIT4 DNA-damage-inducible transcript 4 3.20985
ATP11B ATPase, class VI, type 11B 3.12795
HMOX1 heme oxygenase 1 3.02145
SSBP2 single-stranded DNA binding protein 2 2.8874
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.8607
RNF167 ring finger protein 167 2.75655
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 2.7544
TPD52L2 tumor protein D52-like 2 2.62795
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.62608
JADE2 jade family PHD finger 2 2.57757
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 2.562
ARCN1 archain 1 2.5299
EVL Enah/Vasp-like 2.50875
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.5035
TRIM13 tripartite motif containing 13 2.471
PIH1D1 PIH1 domain containing 1 2.46275
AAMP angio-associated, migratory cell protein 2.45625
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.4475
TSG101 tumor susceptibility 101 2.43835
IFITM2 interferon induced transmembrane protein 2 2.4338
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.4132
GPER1 G protein-coupled estrogen receptor 1 2.39528
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.3453
GAMT guanidinoacetate N-methyltransferase 2.2731
RHOG ras homolog family member G 2.2715
SHCBP1 SHC SH2-domain binding protein 1 2.2571
LOC124908558 X antigen family member 1-like 2.18365
MYG1 MYG1 exonuclease 2.16695
NMU neuromedin U 2.1529
ILK integrin-linked kinase 2.14115
STK16 serine/threonine kinase 16 2.11925
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.10925
LOC105379278 uncharacterized LOC105379278 2.1011
ZFP36 ZFP36 ring finger protein 2.0983
RTN3 reticulon 3 2.0981
ZFP30 ZFP30 zinc finger protein 2.0946
MAGEA12 melanoma antigen family A12 2.09425
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.08751
SLC25A46 solute carrier family 25, member 46 2.0662
CDK19 cyclin-dependent kinase 19 2.04763
HPN hepsin 2.04595
RPLP1 ribosomal protein, large, P1 2.0387
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.01945
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.0182
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.01025

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
PCNA proliferating cell nuclear antigen -8.34865
THAP11 THAP domain containing 11 -5.37385
FASTKD5 FAST kinase domains 5 -5.23365
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.87215
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.71905
CDC20 cell division cycle 20 -4.66275
TUBB6 tubulin, beta 6 class V -4.6557
CHMP4B charged multivesicular body protein 4B -4.5507
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.46155
MAP7 microtubule-associated protein 7 -4.38593
HMG20B high mobility group 20B -4.15495
KDM3A lysine (K)-specific demethylase 3A -4.1398
FGFR4 fibroblast growth factor receptor 4 -4.1246
EIF5 eukaryotic translation initiation factor 5 -4.11373
CCNB2 cyclin B2 -4.02315
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.9371
TXNRD1 thioredoxin reductase 1 -2.9643
NVL nuclear VCP-like -2.85735
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.82795
FAT1 FAT atypical cadherin 1 -2.7882
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) -2.62375
MACF1 microtubule-actin crosslinking factor 1 -2.57453
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 -2.53387
PRR14 proline rich 14 -2.51023
TBC1D31 TBC1 domain family, member 31 -2.4306
VRK1 vaccinia related kinase 1 -2.3429
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.33925
CA2 carbonic anhydrase II -2.2842
ITGB1BP1 integrin beta 1 binding protein 1 -2.2739
INSIG1 insulin induced gene 1 -2.2415
MEP1A meprin A, alpha (PABA peptide hydrolase) -2.22185
NGRN neugrin, neurite outgrowth associated -2.214
GLOD4 glyoxalase domain containing 4 -2.20015
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.1653
YME1L1 YME1-like 1 ATPase -2.13335
MACROH2A2 macroH2A.2 histone -2.09425
LUM lumican -2.092
ETHE1 ethylmalonic encephalopathy 1 -2.088
TBX2 T-box 2 -2.0656
GUCY2C guanylate cyclase 2C -2.0597
TRIM9 tripartite motif containing 9 -2.0561
MKKS McKusick-Kaufman syndrome -2.0261
MAD2L1BP MAD2L1 binding protein -2.0168
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 -2.0077
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -2.00235