CRCGN011_HEPG2_24H:H22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description triamcinolone 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

146 genes differentially expressed following the CRCGN011_HEPG2_24H:H22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 10.0
LCN2 lipocalin 2 5.3197
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.28187
MYLK myosin light chain kinase 5.23035
CDPF1 cysteine-rich, DPF motif domain containing 1 5.15745
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.99045
ABHD6 abhydrolase domain containing 6 4.25093
CCL2 chemokine (C-C motif) ligand 2 4.11165
E2F2 E2F transcription factor 2 4.0639
SNAP25 synaptosomal-associated protein, 25kDa 3.7771
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.5102
GATA3 GATA binding protein 3 3.49717
SSBP2 single-stranded DNA binding protein 2 3.32072
TERF2 telomeric repeat binding factor 2 3.2892
RAG1 recombination activating gene 1 3.17265
EVL Enah/Vasp-like 2.9419
STAG3 stromal antigen 3 2.9093
FHIT fragile histidine triad 2.8678
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.86285
DDIT4 DNA-damage-inducible transcript 4 2.8579
DOCK2 dedicator of cytokinesis 2 2.8556
CEP57 centrosomal protein 57kDa 2.79217
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.68815
BIRC2 baculoviral IAP repeat containing 2 2.65185
GFI1 growth factor independent 1 transcription repressor 2.6376
CIDEB cell death-inducing DFFA-like effector b 2.60585
KIF5C kinesin family member 5C 2.5711
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.56905
HPS4 Hermansky-Pudlak syndrome 4 2.5397
CDH4 cadherin 4, type 1, R-cadherin (retinal) 2.5033
SLC75A1 solute carrier family 75 member 1 2.4897
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.46895
KLHL9 kelch-like family member 9 2.46392
FPGS folylpolyglutamate synthase 2.4507
POU4F1 POU class 4 homeobox 1 2.449
GPER1 G protein-coupled estrogen receptor 1 2.44798
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.43702
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.3708
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.3429
TFF2 trefoil factor 2 2.3166
MSRB1 methionine sulfoxide reductase B1 2.31245
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 2.3058
IRS1 insulin receptor substrate 1 2.29875
HOXC8 homeobox C8 2.29605
BMP4 bone morphogenetic protein 4 2.2719
TMEM131L transmembrane 131 like 2.26595
CEPT1 choline/ethanolamine phosphotransferase 1 2.2613
CLCN5 chloride channel, voltage-sensitive 5 2.25095
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 2.24633
BCR breakpoint cluster region 2.24575
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.22533
STK32B serine/threonine kinase 32B 2.2101
AZU1 azurocidin 1 2.201
TUBGCP4 tubulin, gamma complex associated protein 4 2.19945
MAK16 MAK16 homolog (S. cerevisiae) 2.1801
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 2.1681
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 2.15525
NUPR1 nuclear protein, transcriptional regulator, 1 2.1512
TSPAN5 tetraspanin 5 2.14085
TCL1B T-cell leukemia/lymphoma 1B 2.14085
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.13565
SNX2 sorting nexin 2 2.13235
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.1159
CD19 CD19 molecule 2.089
DOK7 docking protein 7 2.08763
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.0836
CLINT1 clathrin interactor 1 2.0771
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.07575
ADRA2C adrenoceptor alpha 2C 2.0666
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 2.05778
VNN1 vanin 1 2.0489
CLK3 CDC-like kinase 3 2.04775
CAV2 caveolin 2 2.0446
DNMBP dynamin binding protein 2.03575
NCOA3 nuclear receptor coactivator 3 2.02599
COL5A2 collagen, type V, alpha 2 2.02135
EPCIP exosomal polycystin 1 interacting protein 2.019
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.01645
TM7SF3 transmembrane 7 superfamily member 3 2.01555
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.01435
MID1IP1 MID1 interacting protein 1 2.01325
PEF1 penta-EF-hand domain containing 1 2.00835

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.28815
FABP5 fatty acid binding protein 5 (psoriasis-associated) -6.65485
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.44845
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.38555
LAP3 leucine aminopeptidase 3 -5.34725
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.18105
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.0122
HMG20B high mobility group 20B -4.99325
PUF60 poly-U binding splicing factor 60KDa -4.8985
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.736
CD320 CD320 molecule -4.61695
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.6109
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.96555
PCNA proliferating cell nuclear antigen -3.861
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.77572
RHEB Ras homolog enriched in brain -3.498
SCRIB scribbled planar cell polarity protein -3.42685
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -3.19585
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.15792
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.7512
CX3CL1 chemokine (C-X3-C motif) ligand 1 -2.6293
WASF1 WAS protein family, member 1 -2.6164
VASH1 vasohibin 1 -2.6037
MXD1 MAX dimerization protein 1 -2.5548
MYO1D myosin ID -2.5532
PAIP1 poly(A) binding protein interacting protein 1 -2.50015
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 -2.446
PHC1 polyhomeotic homolog 1 (Drosophila) -2.4311
BTG3 BTG family, member 3 -2.4265
STIP1 stress-induced phosphoprotein 1 -2.40205
TNS2 tensin 2 -2.3808
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.35363
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.35155
GPM6B glycoprotein M6B -2.3174
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.29795
RNF167 ring finger protein 167 -2.2488
ZW10 zw10 kinetochore protein -2.24735
KLHDC3 kelch domain containing 3 -2.24722
PCDH12 protocadherin 12 -2.2349
HOXD1 homeobox D1 -2.2073
GDF15 growth differentiation factor 15 -2.1862
HMGN3 high mobility group nucleosomal binding domain 3 -2.149
NCOA6 nuclear receptor coactivator 6 -2.14655
PHTF1 putative homeodomain transcription factor 1 -2.14093
CXADR coxsackie virus and adenovirus receptor -2.1376
SOX17 SRY (sex determining region Y)-box 17 -2.13205
TMEM184B transmembrane protein 184B -2.1193
CTSV cathepsin V -2.11535
NCKAP1 NCK-associated protein 1 -2.1143
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.10695
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -2.0932
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.06585
RAP2A RAP2A, member of RAS oncogene family -2.06505
U2AF2 U2 small nuclear RNA auxiliary factor 2 -2.065
OSBPL10 oxysterol binding protein-like 10 -2.06
ABR active BCR-related -2.0526
LY6E lymphocyte antigen 6 complex, locus E -2.04675
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.0394
CIC capicua transcriptional repressor -2.0376
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.0315
ADGRF5 adhesion G protein-coupled receptor F5 -2.0246
EDNRB endothelin receptor type B -2.0222
WDR26 WD repeat domain 26 -2.0065
YIPF3 Yip1 domain family, member 3 -2.00475