CRCGN011_HEPG2_24H:I01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methapyrilene 20.82 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

139 genes differentially expressed following the CRCGN011_HEPG2_24H:I01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 5.90392
JADE2 jade family PHD finger 2 5.80595
AMDHD2 amidohydrolase domain containing 2 5.5681
TBPL1 TBP-like 1 5.35125
LCN2 lipocalin 2 5.0185
CBR3 carbonyl reductase 3 4.91485
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.6106
SQOR sulfide quinone oxidoreductase 4.45445
NOTCH1 notch 1 4.2239
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.10675
CCL2 chemokine (C-C motif) ligand 2 3.93105
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.5097
NDN necdin, melanoma antigen (MAGE) family member 3.39905
BIRC2 baculoviral IAP repeat containing 2 3.30825
SSBP2 single-stranded DNA binding protein 2 3.29908
NFIL3 nuclear factor, interleukin 3 regulated 3.27865
PFKL phosphofructokinase, liver 3.20392
ABHD4 abhydrolase domain containing 4 3.0441
ZNF589 zinc finger protein 589 2.99573
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.9296
INPP5F inositol polyphosphate-5-phosphatase F 2.9087
EMC2 ER membrane protein complex subunit 2 2.89645
SCRN1 secernin 1 2.7883
CEP192 centrosomal protein 192kDa 2.77415
HMGA2 high mobility group AT-hook 2 2.73185
RALB v-ral simian leukemia viral oncogene homolog B 2.69625
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.64265
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.6138
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.57082
MOK MOK protein kinase 2.56
FCHO1 FCH domain only 1 2.55645
CCNF cyclin F 2.53903
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.47075
CHEK2 checkpoint kinase 2 2.43318
MFAP1 microfibrillar-associated protein 1 2.39005
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 2.3766
PLPP3 phospholipid phosphatase 3 2.33397
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.2761
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.27265
RBM7 RNA binding motif protein 7 2.272
LASP1 LIM and SH3 protein 1 2.26625
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.2496
PLAGL1 pleiomorphic adenoma gene-like 1 2.24625
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 2.22585
RXYLT1 ribitol xylosyltransferase 1 2.20915
UBXN2B UBX domain protein 2B 2.1783
ARHGAP12 Rho GTPase activating protein 12 2.1765
DIPK1A divergent protein kinase domain 1A 2.16985
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.16502
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.1308
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 2.1178
SERINC5 serine incorporator 5 2.0957
STX10 syntaxin 10 2.088
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.08555
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.084
THY1 Thy-1 cell surface antigen 2.07548
TXNRD1 thioredoxin reductase 1 2.06555
NNT nicotinamide nucleotide transhydrogenase 2.0654
VTI1B vesicle transport through interaction with t-SNAREs 1B 2.0286
BANP BTG3 associated nuclear protein 2.0183
CKAP5 cytoskeleton associated protein 5 2.01445

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -10.0
SLC35F2 solute carrier family 35, member F2 -7.03355
PCCB propionyl CoA carboxylase, beta polypeptide -5.7942
KDM3A lysine (K)-specific demethylase 3A -5.47785
LAP3 leucine aminopeptidase 3 -5.32875
FAIM Fas apoptotic inhibitory molecule -4.99135
ZMIZ1 zinc finger, MIZ-type containing 1 -4.8239
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.62635
UBE3C ubiquitin protein ligase E3C -4.2247
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.1544
TCTN1 tectonic family member 1 -4.1173
ADI1 acireductone dioxygenase 1 -3.953
GRWD1 glutamate-rich WD repeat containing 1 -3.7178
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.69168
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.64635
GNAS GNAS complex locus -3.54189
NGRN neugrin, neurite outgrowth associated -3.363
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.01318
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.88317
RFC2 replication factor C (activator 1) 2, 40kDa -2.86955
ZNF274 zinc finger protein 274 -2.82975
RTN1 reticulon 1 -2.816
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.80505
TBC1D31 TBC1 domain family, member 31 -2.7558
IPO13 importin 13 -2.7373
SNX11 sorting nexin 11 -2.68415
LIMS2 LIM and senescent cell antigen-like domains 2 -2.6499
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.64722
SPEG SPEG complex locus -2.56125
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.4521
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.45035
BRSK2 BR serine/threonine kinase 2 -2.4255
PLA2G12A phospholipase A2, group XIIA -2.3973
TMEM14B transmembrane protein 14B -2.39515
RNF167 ring finger protein 167 -2.38145
NALF2 NALCN channel auxiliary factor 2 -2.37565
VPS9D1 VPS9 domain containing 1 -2.34705
SMAD9 SMAD family member 9 -2.3437
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -2.33975
SCN1B sodium channel, voltage gated, type I beta subunit -2.32835
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.3215
PNPO pyridoxamine 5'-phosphate oxidase -2.3138
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -2.3055
NPDC1 neural proliferation, differentiation and control, 1 -2.2757
PCGF1 polycomb group ring finger 1 -2.27527
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.275
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -2.2692
THADA thyroid adenoma associated -2.25672
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.24135
CBLN1 cerebellin 1 precursor -2.2394
ACTL6A actin-like 6A -2.23025
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.1943
C2CD2 C2 calcium-dependent domain containing 2 -2.1838
SCIN scinderin -2.1838
METTL2A methyltransferase like 2A -2.17817
NEUROD1 neuronal differentiation 1 -2.1779
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.1715
CHRNG cholinergic receptor, nicotinic, gamma (muscle) -2.1686
SPAG4 sperm associated antigen 4 -2.1568
GREB1L growth regulation by estrogen in breast cancer-like -2.14675
CCDC106 coiled-coil domain containing 106 -2.13625
UBFD1 ubiquitin family domain containing 1 -2.12565
EPHA7 EPH receptor A7 -2.1215
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.1115
RUSC2 RUN and SH3 domain containing 2 -2.11
DERL1 derlin 1 -2.0985
SLC66A2 solute carrier family 66 member 2 -2.0967
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D -2.0879
PCDHA9 protocadherin alpha 9 -2.0813
WBP2 WW domain binding protein 2 -2.07375
NRIP1 nuclear receptor interacting protein 1 -2.07178
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) -2.0632
ATP5ME ATP synthase membrane subunit e -2.04555
RAB36 RAB36, member RAS oncogene family -2.0417
NKX2-1 NK2 homeobox 1 -2.0256
ZNF212 zinc finger protein 212 -2.0241
SHARPIN SHANK-associated RH domain interactor -2.0176
PAQR3 progestin and adipoQ receptor family member III -2.0003