CRCGN011_HEPG2_24H:I02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methapyrilene 10.41 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

134 genes differentially expressed following the CRCGN011_HEPG2_24H:I02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
LCN2 lipocalin 2 8.4443
PLS1 plastin 1 6.3523
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.6169
CSK c-src tyrosine kinase 5.48555
EPHB2 EPH receptor B2 5.19518
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.0406
ADRB2 adrenoceptor beta 2, surface 4.9665
ADGRE5 adhesion G protein-coupled receptor E5 4.9631
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.4776
UBQLN2 ubiquilin 2 4.38965
HOXA10 homeobox A10 4.09035
MOK MOK protein kinase 3.96145
MAP7 microtubule-associated protein 7 3.6717
LOC122526780 uncharacterized LOC122526780 3.61215
GPER1 G protein-coupled estrogen receptor 1 3.5265
CHMP6 charged multivesicular body protein 6 3.46395
ADAT1 adenosine deaminase, tRNA-specific 1 3.33535
FASTKD5 FAST kinase domains 5 3.26875
CTSL cathepsin L 3.2622
SSBP2 single-stranded DNA binding protein 2 3.22445
HLA-DRA major histocompatibility complex, class II, DR alpha 2.89812
MAST2 microtubule associated serine/threonine kinase 2 2.85202
NMU neuromedin U 2.7976
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.6823
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.58203
HMGA2 high mobility group AT-hook 2 2.52425
GPATCH8 G patch domain containing 8 2.5118
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.49565
PIH1D1 PIH1 domain containing 1 2.4875
CEMIP2 cell migration inducing hyaluronidase 2 2.47425
CHN1 chimerin 1 2.4502
ANGPT4 angiopoietin 4 2.4373
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.40816
CAAP1 caspase activity and apoptosis inhibitor 1 2.37955
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.34443
ZNHIT2 zinc finger, HIT-type containing 2 2.3039
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.28395
CYCS cytochrome c, somatic 2.2796
CDX1 caudal type homeobox 1 2.2672
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.25525
BICRAL BICRA like chromatin remodeling complex associated protein 2.24898
FGFBP1 fibroblast growth factor binding protein 1 2.2475
TEX28 testis expressed 28 2.2129
CD33 CD33 molecule 2.209
SHH sonic hedgehog 2.20115
ZNF589 zinc finger protein 589 2.1676
F5 coagulation factor V (proaccelerin, labile factor) 2.16552
TMPRSS6 transmembrane protease, serine 6 2.16095
INTS14 integrator complex subunit 14 2.1557
GJA3 gap junction protein, alpha 3, 46kDa 2.1513
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.1442
POC1B-GALNT4 POC1B-GALNT4 readthrough 2.12895
PMM2 phosphomannomutase 2 2.1176
PRB2 proline-rich protein BstNI subfamily 2 2.11217
MEF2B myocyte enhancer factor 2B 2.11215
WNT7A wingless-type MMTV integration site family, member 7A 2.11125
ATOH1 atonal homolog 1 (Drosophila) 2.1096
CCL24 chemokine (C-C motif) ligand 24 2.1063
CCNA1 cyclin A1 2.1031
SCRT1 scratch family zinc finger 1 2.09245
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.09055
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.0852
GPR27 G protein-coupled receptor 27 2.08155
KLHL9 kelch-like family member 9 2.07842
PEX2 peroxisomal biogenesis factor 2 2.064
HOXA11 homeobox A11 2.05708
ZNF280D zinc finger protein 280D 2.05585
RCVRN recoverin 2.04785
MCM3 minichromosome maintenance complex component 3 2.03935
CSDC2 cold shock domain containing C2, RNA binding 2.0345
PRAMEF10 PRAME family member 10 2.03025
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.0248
FOXL2 forkhead box L2 2.019
PPME1 protein phosphatase methylesterase 1 2.01367
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.00915
CRIPTO3 cripto, EGF-CFC family member 3 2.00605

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -10.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.5345
MRPS2 mitochondrial ribosomal protein S2 -5.3627
ARID5B AT rich interactive domain 5B (MRF1-like) -5.3198
ADI1 acireductone dioxygenase 1 -4.8371
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.83565
LDHD lactate dehydrogenase D -4.66975
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.65675
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.60715
RHEB Ras homolog enriched in brain -4.51903
CHMP4B charged multivesicular body protein 4B -4.35588
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.1535
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.97425
HMG20B high mobility group 20B -3.8367
GNAS GNAS complex locus -3.56422
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.49905
MAPK13 mitogen-activated protein kinase 13 -3.35075
GRWD1 glutamate-rich WD repeat containing 1 -3.20135
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.82965
ZNF274 zinc finger protein 274 -2.80845
LRRC41 leucine rich repeat containing 41 -2.71493
SCML1 sex comb on midleg-like 1 (Drosophila) -2.56325
NELFB negative elongation factor complex member B -2.55285
RGS2 regulator of G-protein signaling 2 -2.4832
FASTK Fas-activated serine/threonine kinase -2.45372
MGST3 microsomal glutathione S-transferase 3 -2.4319
STX4 syntaxin 4 -2.39155
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -2.3763
GPX4 glutathione peroxidase 4 -2.37525
DSN1 DSN1, MIS12 kinetochore complex component -2.3599
SRI sorcin -2.34273
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 -2.33428
PILRB paired immunoglobin-like type 2 receptor beta -2.3305
PDCD5 programmed cell death 5 -2.3251
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.31888
TRADD TNFRSF1A-associated via death domain -2.28207
ABHD17A abhydrolase domain containing 17A -2.2756
CHEK1 checkpoint kinase 1 -2.24555
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.2033
DENND5A DENN/MADD domain containing 5A -2.19685
COBL cordon-bleu WH2 repeat protein -2.1768
CD207 CD207 molecule, langerin -2.1764
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -2.17035
SMYD5 SMYD family member 5 -2.14585
NRIP1 nuclear receptor interacting protein 1 -2.14145
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.13685
MADD MAP-kinase activating death domain -2.13637
RPS5 ribosomal protein S5 -2.13425
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.11555
ZNF646 zinc finger protein 646 -2.1118
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.10572
GTPBP2 GTP binding protein 2 -2.0954
TUFM Tu translation elongation factor, mitochondrial -2.04465
PPIF peptidylprolyl isomerase F -2.03785
SELENOW selenoprotein W -2.01485
RNF13 ring finger protein 13 -2.00525
THOP1 thimet oligopeptidase 1 -2.00035