CRCGN011_HEPG2_24H:I03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methapyrilene 5.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

163 genes differentially expressed following the CRCGN011_HEPG2_24H:I03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 5.9583
STAP2 signal transducing adaptor family member 2 5.43335
UBQLN2 ubiquilin 2 5.17445
PPARG peroxisome proliferator-activated receptor gamma 4.78145
CARMIL1 capping protein regulator and myosin 1 linker 1 4.74135
PEX11A peroxisomal biogenesis factor 11 alpha 4.44193
AMDHD2 amidohydrolase domain containing 2 4.0708
CYCS cytochrome c, somatic 3.4409
PRR15L proline rich 15-like 3.37675
TLR4 toll-like receptor 4 3.35415
WDTC1 WD and tetratricopeptide repeats 1 3.15815
COL11A1 collagen, type XI, alpha 1 3.1273
SNX7 sorting nexin 7 3.0024
PCDHB11 protocadherin beta 11 2.88071
SP3 Sp3 transcription factor 2.81555
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.78995
JADE2 jade family PHD finger 2 2.77588
TIAM1 T-cell lymphoma invasion and metastasis 1 2.70973
GPER1 G protein-coupled estrogen receptor 1 2.7078
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 2.68907
ANGPTL4 angiopoietin-like 4 2.6623
TTC33 tetratricopeptide repeat domain 33 2.64965
TCF20 transcription factor 20 (AR1) 2.6289
MZB1 marginal zone B and B1 cell-specific protein 2.5539
PMM2 phosphomannomutase 2 2.553
ZC4H2 zinc finger, C4H2 domain containing 2.52165
DIPK1A divergent protein kinase domain 1A 2.4942
GPATCH8 G patch domain containing 8 2.48843
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.4392
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.42025
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.38905
CST4 cystatin S 2.35195
CENPQ centromere protein Q 2.2896
CCNF cyclin F 2.2817
SUB1 SUB1 homolog (S. cerevisiae) 2.26508
TMEM106B transmembrane protein 106B 2.2497
DMXL1 Dmx-like 1 2.2379
KIF4A kinesin family member 4A 2.23625
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.22945
TPD52L2 tumor protein D52-like 2 2.22555
CEP55 centrosomal protein 55kDa 2.22055
UST uronyl-2-sulfotransferase 2.2131
EMP3 epithelial membrane protein 3 2.20805
BLTP3B bridge-like lipid transfer protein family member 3B 2.2045
GALR3 galanin receptor 3 2.2017
KCTD5 potassium channel tetramerization domain containing 5 2.19105
TENT4A terminal nucleotidyltransferase 4A 2.1668
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 2.1479
EDN2 endothelin 2 2.11825
LMBRD1 LMBR1 domain containing 1 2.11335
L1TD1 LINE-1 type transposase domain containing 1 2.10215
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.0801
MEP1B meprin A, beta 2.07875
LGALS4 lectin, galactoside-binding, soluble, 4 2.06575
AADAC arylacetamide deacetylase 2.06225
TECR trans-2,3-enoyl-CoA reductase 2.0568
PAOX polyamine oxidase (exo-N4-amino) 2.0479
KRT20 keratin 20, type I 2.0478
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.0452
CRELD2 cysteine-rich with EGF-like domains 2 2.0443
TCTN2 tectonic family member 2 2.03465
HAS2 hyaluronan synthase 2 2.031
TFF3 trefoil factor 3 (intestinal) 2.0284
CHMP1A charged multivesicular body protein 1A 2.01645
PIBF1 progesterone immunomodulatory binding factor 1 2.0033

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -10.0
ADI1 acireductone dioxygenase 1 -8.003
GNAS GNAS complex locus -7.14376
GDF15 growth differentiation factor 15 -6.4085
COG7 component of oligomeric golgi complex 7 -5.98265
PECR peroxisomal trans-2-enoyl-CoA reductase -5.16325
NT5DC2 5'-nucleotidase domain containing 2 -5.0
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.8267
LDHD lactate dehydrogenase D -4.66275
LAP3 leucine aminopeptidase 3 -4.6368
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -4.56405
TRIB3 tribbles pseudokinase 3 -4.54085
RPIA ribose 5-phosphate isomerase A -4.29535
MAP7 microtubule-associated protein 7 -4.28037
EIF5 eukaryotic translation initiation factor 5 -3.9824
OXA1L oxidase (cytochrome c) assembly 1-like -3.51915
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.40695
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.25805
ZNF652 zinc finger protein 652 -2.963
RAB5IF RAB5 interacting factor -2.9123
HAUS3 HAUS augmin-like complex, subunit 3 -2.8006
ZNF276 zinc finger protein 276 -2.77155
UBFD1 ubiquitin family domain containing 1 -2.7048
PRPF4 pre-mRNA processing factor 4 -2.69707
NCALD neurocalcin delta -2.6903
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.674
RMDN3 regulator of microtubule dynamics 3 -2.6224
STX18 syntaxin 18 -2.6221
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.5931
HTD2 hydroxyacyl-thioester dehydratase type 2 -2.591
ITGB1BP1 integrin beta 1 binding protein 1 -2.51857
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.51587
NGRN neugrin, neurite outgrowth associated -2.4924
FOS FBJ murine osteosarcoma viral oncogene homolog -2.4548
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.4436
CCNB2 cyclin B2 -2.43335
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.42825
MAEA macrophage erythroblast attacher -2.35655
MED28 mediator complex subunit 28 -2.3446
AVEN apoptosis, caspase activation inhibitor -2.3019
METTL9 methyltransferase like 9 -2.2971
DYSF dysferlin -2.29665
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.28075
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -2.27898
CLSTN3 calsyntenin 3 -2.27395
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.2709
ASB8 ankyrin repeat and SOCS box containing 8 -2.2566
LMO2 LIM domain only 2 (rhombotin-like 1) -2.241
IFT22 intraflagellar transport 22 -2.23715
SNX3 sorting nexin 3 -2.23272
GPS1 G protein pathway suppressor 1 -2.2275
RPL27A ribosomal protein L27a -2.2249
GLRX5 glutaredoxin 5 -2.2168
SUOX sulfite oxidase -2.21415
MITF microphthalmia-associated transcription factor -2.2122
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.2102
TSPYL4 TSPY-like 4 -2.207
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.2022
MYH10 myosin, heavy chain 10, non-muscle -2.19648
LDHB lactate dehydrogenase B -2.18587
MTA1 metastasis associated 1 -2.18488
LMAN2L lectin, mannose-binding 2-like -2.1785
LOC128125814 uncharacterized LOC128125814 -2.1658
MSTO1 misato 1, mitochondrial distribution and morphology regulator -2.1657
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -2.1648
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -2.16055
EDC3 enhancer of mRNA decapping 3 -2.1565
DCAF16 DDB1 and CUL4 associated factor 16 -2.1548
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.1506
RSRP1 arginine/serine-rich protein 1 -2.15058
FAM107A family with sequence similarity 107, member A -2.14805
USP39 ubiquitin specific peptidase 39 -2.128
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.1258
MEIS1 Meis homeobox 1 -2.12255
NTM neurotrimin -2.1108
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.10045
LYRM9 LYR motif containing 9 -2.0977
CIAO1 cytosolic iron-sulfur assembly component 1 -2.09168
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin -2.0902
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) -2.08795
RFXANK regulatory factor X-associated ankyrin-containing protein -2.0806
SLC44A1 solute carrier family 44 (choline transporter), member 1 -2.068
RPS11 ribosomal protein S11 -2.06545
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.0559
RSRC2 arginine/serine-rich coiled-coil 2 -2.05342
GAK cyclin G associated kinase -2.05067
PCNT pericentrin -2.0385
A2M alpha-2-macroglobulin -2.0385
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.03565
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -2.02815
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) -2.0272
HMBOX1 homeobox containing 1 -2.026
ASB7 ankyrin repeat and SOCS box containing 7 -2.0244
CDV3 CDV3 homolog (mouse) -2.0243
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.023
FLCN folliculin -2.02145
HOXB2 homeobox B2 -2.02115
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 -2.02087