CRCGN011_HEPG2_24H:I04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methapyrilene 2.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

123 genes differentially expressed following the CRCGN011_HEPG2_24H:I04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 10.0
UBQLN2 ubiquilin 2 10.0
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 10.0
GPATCH8 G patch domain containing 8 6.12485
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.4165
PNKP polynucleotide kinase 3'-phosphatase 4.8482
CARMIL1 capping protein regulator and myosin 1 linker 1 4.8434
MYLK myosin light chain kinase 4.8257
PPARG peroxisome proliferator-activated receptor gamma 4.8117
MINDY1 MINDY lysine 48 deubiquitinase 1 4.5977
NFIL3 nuclear factor, interleukin 3 regulated 4.5599
MCOLN1 mucolipin 1 4.44775
FZD7 frizzled class receptor 7 4.38905
PEX11A peroxisomal biogenesis factor 11 alpha 4.38865
NOTCH1 notch 1 4.20875
STIMATE STIM activating enhancer 4.01065
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.94453
ABHD6 abhydrolase domain containing 6 3.49752
SSBP2 single-stranded DNA binding protein 2 3.02813
ADGRE5 adhesion G protein-coupled receptor E5 3.02565
TIAM1 T-cell lymphoma invasion and metastasis 1 2.97843
SNX7 sorting nexin 7 2.91905
DYNLT3 dynein, light chain, Tctex-type 3 2.8579
PLSCR3 phospholipid scramblase 3 2.8508
CPNE3 copine III 2.8309
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.7764
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.76435
GYG2 glycogenin 2 2.72738
IGSF1 immunoglobulin superfamily, member 1 2.6366
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.552
IL11RA interleukin 11 receptor, alpha 2.5472
TSHB thyroid stimulating hormone, beta 2.5337
MXRA8 matrix-remodelling associated 8 2.5292
DUOX2 dual oxidase 2 2.5242
KRT75 keratin 75, type II 2.5181
LMO3 LIM domain only 3 (rhombotin-like 2) 2.4748
NUP133 nucleoporin 133kDa 2.44955
CCNF cyclin F 2.44252
COQ8A coenzyme Q8A 2.4187
MCTP2 multiple C2 domains, transmembrane 2 2.4181
EVL Enah/Vasp-like 2.41385
COG4 component of oligomeric golgi complex 4 2.41295
IL12RB2 interleukin 12 receptor, beta 2 2.407
KNTC1 kinetochore associated 1 2.3704
RXRG retinoid X receptor, gamma 2.35235
ADAT1 adenosine deaminase, tRNA-specific 1 2.3504
MEST mesoderm specific transcript 2.34905
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.33803
GAL3ST4 galactose-3-O-sulfotransferase 4 2.3138
ROPN1B rhophilin associated tail protein 1B 2.2758
TG thyroglobulin 2.27265
COL6A2 collagen, type VI, alpha 2 2.27105
ITGA9 integrin, alpha 9 2.2334
ACACB acetyl-CoA carboxylase beta 2.20712
GALR3 galanin receptor 3 2.20525
JADE2 jade family PHD finger 2 2.20162
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.1979
TRMT9B tRNA methyltransferase 9B (putative) 2.1978
S100B S100 calcium binding protein B 2.18555
CT55 cancer/testis antigen 55 2.15775
CNGA1 cyclic nucleotide gated channel alpha 1 2.1488
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.1393
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.13885
NMU neuromedin U 2.13715
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.12265
PARM1 prostate androgen-regulated mucin-like protein 1 2.1004
GHRHR growth hormone releasing hormone receptor 2.08463
PAX9 paired box 9 2.0826
ACBD3 acyl-CoA binding domain containing 3 2.0744
ZNF280A zinc finger protein 280A 2.0701
RANBP6 RAN binding protein 6 2.0637
BIN3 bridging integrator 3 2.05115
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 2.03775
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.0376
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.0345
GFRA2 GDNF family receptor alpha 2 2.0286
PLCD1 phospholipase C, delta 1 2.0284
HLA-DRA major histocompatibility complex, class II, DR alpha 2.02378
STAT4 signal transducer and activator of transcription 4 2.0228
COL5A3 collagen, type V, alpha 3 2.0225
COL11A1 collagen, type XI, alpha 1 2.02055
ARMCX3 armadillo repeat containing, X-linked 3 2.01745

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.85145
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.433
TRIB3 tribbles pseudokinase 3 -5.0
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.97945
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.9119
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.8803
NT5DC2 5'-nucleotidase domain containing 2 -4.87075
VAT1 vesicle amine transport 1 -4.86915
RGS2 regulator of G-protein signaling 2 -3.5322
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.2915
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -3.25645
PCNA proliferating cell nuclear antigen -2.97645
NPDC1 neural proliferation, differentiation and control, 1 -2.91325
TLCD3A TLC domain containing 3A -2.8129
C2CD2 C2 calcium-dependent domain containing 2 -2.75355
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.65913
RNF167 ring finger protein 167 -2.5727
WASHC4 WASH complex subunit 4 -2.54047
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.48225
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.45845
FBXL12 F-box and leucine-rich repeat protein 12 -2.4166
CD58 CD58 molecule -2.32233
DRAM1 DNA-damage regulated autophagy modulator 1 -2.2609
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.2333
BORCS6 BLOC-1 related complex subunit 6 -2.2275
BICD1 bicaudal D homolog 1 (Drosophila) -2.20105
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.19975
DCK deoxycytidine kinase -2.1826
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.1785
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1612
FIBP fibroblast growth factor (acidic) intracellular binding protein -2.0988
NIT2 nitrilase family, member 2 -2.0987
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -2.0923
SAC3D1 SAC3 domain containing 1 -2.086
NT5C 5', 3'-nucleotidase, cytosolic -2.0598
SAV1 salvador family WW domain containing protein 1 -2.04805
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.0246
CDR2L cerebellar degeneration-related protein 2-like -2.016
SOAT2 sterol O-acyltransferase 2 -2.01548
RFC2 replication factor C (activator 1) 2, 40kDa -2.00085
CUEDC2 CUE domain containing 2 -2.00055