CRCGN011_HEPG2_24H:I05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methapyrilene 1.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

79 genes differentially expressed following the CRCGN011_HEPG2_24H:I05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RPP38 ribonuclease P/MRP 38kDa subunit 5.75385
BACE2 beta-site APP-cleaving enzyme 2 5.099
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.94545
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.90175
CCL2 chemokine (C-C motif) ligand 2 4.7269
CARMIL1 capping protein regulator and myosin 1 linker 1 4.658
CCDC85B coiled-coil domain containing 85B 3.9407
MICALL1 MICAL-like 1 3.86382
MAP7 microtubule-associated protein 7 3.73547
MEST mesoderm specific transcript 3.64455
HOXA10 homeobox A10 3.3712
ABHD6 abhydrolase domain containing 6 3.3509
CHEK2 checkpoint kinase 2 3.2898
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.22518
GPER1 G protein-coupled estrogen receptor 1 3.20447
KIN Kin17 DNA and RNA binding protein 2.98545
SSBP2 single-stranded DNA binding protein 2 2.9086
GPATCH8 G patch domain containing 8 2.83138
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.74345
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.73572
JADE2 jade family PHD finger 2 2.61475
CRELD2 cysteine-rich with EGF-like domains 2 2.42865
MMP2 matrix metallopeptidase 2 2.42735
F5 coagulation factor V (proaccelerin, labile factor) 2.41782
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.417
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.40545
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.37345
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.33355
A1CF APOBEC1 complementation factor 2.3015
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) 2.296
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.28745
RXYLT1 ribitol xylosyltransferase 1 2.25875
XDH xanthine dehydrogenase 2.2585
TMEM165 transmembrane protein 165 2.2229
CTAGE8 CTAGE family, member 8 2.19763
COIL coilin 2.19025
ARHGAP12 Rho GTPase activating protein 12 2.18995
CNTRL centriolin 2.1758
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.1615
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.10615
GCHFR GTP cyclohydrolase I feedback regulator 2.0992
ATP5F1C ATP synthase F1 subunit gamma 2.0904
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.07068
CASP8AP2 caspase 8 associated protein 2 2.0698
ADGRG6 adhesion G protein-coupled receptor G6 2.0418
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.03995
VTA1 vesicle (multivesicular body) trafficking 1 2.02925
CRHBP corticotropin releasing hormone binding protein 2.02905
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.0105
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 2.0038

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -7.00635
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
GDF15 growth differentiation factor 15 -5.0
CDC20 cell division cycle 20 -5.0
HMG20B high mobility group 20B -4.42033
FBXL12 F-box and leucine-rich repeat protein 12 -4.4072
ANKRD10 ankyrin repeat domain 10 -4.3243
GRWD1 glutamate-rich WD repeat containing 1 -4.2938
CD320 CD320 molecule -4.2487
MALT1 MALT1 paracaspase -3.17722
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.9452
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.83225
PRPF4 pre-mRNA processing factor 4 -2.72055
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.54097
WT1 Wilms tumor 1 -2.41345
CAB39 calcium binding protein 39 -2.39195
HEATR1 HEAT repeat containing 1 -2.33335
ITGB1BP1 integrin beta 1 binding protein 1 -2.32673
GLOD4 glyoxalase domain containing 4 -2.20815
SMPX small muscle protein, X-linked -2.19195
PCCA propionyl CoA carboxylase, alpha polypeptide -2.1838
KIAA0232 KIAA0232 -2.1242
MMP23B matrix metallopeptidase 23B -2.1175
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) -2.07377
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -2.05632
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.05195
FBXL8 F-box and leucine-rich repeat protein 8 -2.03745
FLNA filamin A, alpha -2.01228