CRCGN011_HEPG2_24H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 20.96 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

104 genes differentially expressed following the CRCGN011_HEPG2_24H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIFBP kinesin family binding protein 7.40505
CNPY3 canopy FGF signaling regulator 3 5.40285
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.1559
E2F2 E2F transcription factor 2 5.07845
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.4838
PRR15L proline rich 15-like 4.3167
MAP7 microtubule-associated protein 7 4.17025
VAT1 vesicle amine transport 1 4.03155
CXCL2 chemokine (C-X-C motif) ligand 2 3.99605
VAV3 vav 3 guanine nucleotide exchange factor 3.84667
MEST mesoderm specific transcript 3.73215
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.6456
SQOR sulfide quinone oxidoreductase 3.56805
MVP major vault protein 3.53715
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.23125
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.212
WDTC1 WD and tetratricopeptide repeats 1 3.05707
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.913
STAP2 signal transducing adaptor family member 2 2.84575
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.814
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.65167
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 2.5959
MMP2 matrix metallopeptidase 2 2.59515
TBXA2R thromboxane A2 receptor 2.50526
H2AP H2A.P histone 2.5037
GATA2 GATA binding protein 2 2.48133
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2.45445
H2BC21 H2B clustered histone 21 2.4274
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.36815
EDN1 endothelin 1 2.34875
BTNL8 butyrophilin-like 8 2.29175
ACOT9 acyl-CoA thioesterase 9 2.2866
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.2754
GLRX glutaredoxin (thioltransferase) 2.27503
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.2619
EFCC1 EF-hand and coiled-coil domain containing 1 2.2586
ETFB electron-transfer-flavoprotein, beta polypeptide 2.2572
WNT11 wingless-type MMTV integration site family, member 11 2.23945
PSG6 pregnancy specific beta-1-glycoprotein 6 2.22818
HPGDS hematopoietic prostaglandin D synthase 2.2198
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.2074
BPY2B basic charge, Y-linked, 2B 2.20265
TH tyrosine hydroxylase 2.2016
MICU2 mitochondrial calcium uptake 2 2.19495
ZFP36 ZFP36 ring finger protein 2.16745
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.1554
PSG9 pregnancy specific beta-1-glycoprotein 9 2.14963
SNX7 sorting nexin 7 2.147
BMP10 bone morphogenetic protein 10 2.11445
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2.11215
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.10445
PSG5 pregnancy specific beta-1-glycoprotein 5 2.0908
CCDC87 coiled-coil domain containing 87 2.0887
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.0851
STN1 STN1 subunit of CST complex 2.0634
OR2H1 olfactory receptor, family 2, subfamily H, member 1 2.06235
PLSCR2 phospholipid scramblase 2 2.0603
SYNGAP1 synaptic Ras GTPase activating protein 1 2.05552
SPRYD7 SPRY domain containing 7 2.04175
TRIM2 tripartite motif containing 2 2.03969
TEP1 telomerase-associated protein 1 2.033
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.03025
H1-3 H1.3 linker histone, cluster member 2.0191
IFNA21 interferon, alpha 21 2.01745
CCR3 chemokine (C-C motif) receptor 3 2.01275
DNAH2 dynein, axonemal, heavy chain 2 2.00715

decreased expression

Symbol Name Standardized Value
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -7.5785
LOC124907782 dual specificity protein phosphatase 22 -5.89435
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.44745
LDHD lactate dehydrogenase D -5.08555
FBXL12 F-box and leucine-rich repeat protein 12 -4.7667
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.44115
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.25935
GOLT1B golgi transport 1B -4.14355
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.0188
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.8643
CCNB2 cyclin B2 -3.7493
GNAS GNAS complex locus -3.58409
VDAC1 voltage-dependent anion channel 1 -3.38758
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.96095
RNF167 ring finger protein 167 -2.884
FHL2 four and a half LIM domains 2 -2.73315
LBR lamin B receptor -2.6544
PLK1 polo-like kinase 1 -2.64015
TYK2 tyrosine kinase 2 -2.58245
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 -2.55268
NRIP1 nuclear receptor interacting protein 1 -2.53755
NUP62 nucleoporin 62kDa -2.49013
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.4862
TCERG1 transcription elongation regulator 1 -2.42535
EIF5 eukaryotic translation initiation factor 5 -2.40477
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.3813
HEATR1 HEAT repeat containing 1 -2.35532
C5 complement component 5 -2.29655
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.1627
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.15035
RPS5 ribosomal protein S5 -2.1282
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.11795
CDKN2A cyclin-dependent kinase inhibitor 2A -2.0926
TCEAL4 transcription elongation factor A (SII)-like 4 -2.0484
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.02645
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.01585
SLC35B1 solute carrier family 35, member B1 -2.0131
HEATR3 HEAT repeat containing 3 -2.0013