CRCGN011_HEPG2_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 10.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN011_HEPG2_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AURKB aurora kinase B 5.7519
PLS1 plastin 1 5.734
PPARG peroxisome proliferator-activated receptor gamma 5.705
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 5.68495
NMU neuromedin U 5.55205
SQOR sulfide quinone oxidoreductase 4.8225
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.66275
TLR4 toll-like receptor 4 4.55995
PMM2 phosphomannomutase 2 4.104
CDC45 cell division cycle 45 3.9161
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.72315
MVP major vault protein 3.7127
VAT1 vesicle amine transport 1 3.61065
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.4739
STIMATE STIM activating enhancer 3.4288
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.4279
STAP2 signal transducing adaptor family member 2 3.3692
SHB Src homology 2 domain containing adaptor protein B 3.34473
TESK1 testis-specific kinase 1 3.30525
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.21385
GATA3 GATA binding protein 3 3.11973
PIH1D1 PIH1 domain containing 1 3.06965
DYNLT3 dynein, light chain, Tctex-type 3 3.065
RNF167 ring finger protein 167 2.96275
VGLL4 vestigial-like family member 4 2.8935
NENF neudesin neurotrophic factor 2.85092
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.77295
KIFBP kinesin family binding protein 2.69765
SCML1 sex comb on midleg-like 1 (Drosophila) 2.679
EPHA3 EPH receptor A3 2.64557
CGRRF1 cell growth regulator with ring finger domain 1 2.57855
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.534
MOCS2 molybdenum cofactor synthesis 2 2.4555
SCRN1 secernin 1 2.4134
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.41265
MMP2 matrix metallopeptidase 2 2.4121
JADE2 jade family PHD finger 2 2.352
FPGS folylpolyglutamate synthase 2.31725
RAI14 retinoic acid induced 14 2.2938
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.29005
CBR1 carbonyl reductase 1 2.2431
EPS8 epidermal growth factor receptor pathway substrate 8 2.22145
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.19165
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.1688
PTK2 protein tyrosine kinase 2 2.16855
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.1537
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.13685
EDN3 endothelin 3 2.1107
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.09995
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.09905
IL1B interleukin 1, beta 2.07543
SNAP29 synaptosomal-associated protein, 29kDa 2.06635
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 2.0607
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.03805
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.0246
SBSPON somatomedin B and thrombospondin, type 1 domain containing 2.02425
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.022
CEMIP2 cell migration inducing hyaluronidase 2 2.02095
AICDA activation-induced cytidine deaminase 2.0188
ZNF362 zinc finger protein 362 2.01595
CNPY3 canopy FGF signaling regulator 3 2.0

decreased expression

Symbol Name Standardized Value
ARFIP2 ADP-ribosylation factor interacting protein 2 -5.33385
FASTKD5 FAST kinase domains 5 -5.21675
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0381
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.957
CHMP4B charged multivesicular body protein 4B -4.72328
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.45065
TLCD3A TLC domain containing 3A -4.3991
KDM3A lysine (K)-specific demethylase 3A -4.3847
DDIT4 DNA-damage-inducible transcript 4 -4.1271
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.7981
LOC124907782 dual specificity protein phosphatase 22 -3.6858
IFRD2 interferon-related developmental regulator 2 -3.559
PCNA proliferating cell nuclear antigen -3.4523
HEATR1 HEAT repeat containing 1 -3.41147
UBE2C ubiquitin-conjugating enzyme E2C -3.3985
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.39653
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.36285
PSRC1 proline/serine-rich coiled-coil 1 -3.0949
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.8202
PHF21A PHD finger protein 21A -2.63195
KIF14 kinesin family member 14 -2.61195
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.59485
SPAG4 sperm associated antigen 4 -2.52405
TCERG1 transcription elongation regulator 1 -2.46885
RPS5 ribosomal protein S5 -2.43905
XPO7 exportin 7 -2.42112
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.37995
FOXJ1 forkhead box J1 -2.36095
HBQ1 hemoglobin, theta 1 -2.34425
MTA1 metastasis associated 1 -2.29717
WASHC4 WASH complex subunit 4 -2.28
PLK1 polo-like kinase 1 -2.2055
WDR7 WD repeat domain 7 -2.16935
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.16902
TRAP1 TNF receptor-associated protein 1 -2.1207
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.11895
SOAT2 sterol O-acyltransferase 2 -2.11735
AEN apoptosis enhancing nuclease -2.117
ANAPC1 anaphase promoting complex subunit 1 -2.10465
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -2.0588
ZNF274 zinc finger protein 274 -2.05015
WEE1 WEE1 G2 checkpoint kinase -2.04597
HLA-DMA major histocompatibility complex, class II, DM alpha -2.04155
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.03505
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.01693
PMP2 peripheral myelin protein 2 -2.0034
SLC35F2 solute carrier family 35, member F2 -2.0024