CRCGN011_HEPG2_24H:I10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 2.62 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

147 genes differentially expressed following the CRCGN011_HEPG2_24H:I10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PFKL phosphofructokinase, liver 6.78833
MSRA methionine sulfoxide reductase A 5.69285
MOK MOK protein kinase 5.5379
BZW2 basic leucine zipper and W2 domains 2 5.21905
PPARG peroxisome proliferator-activated receptor gamma 4.97135
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.9642
CARMIL1 capping protein regulator and myosin 1 linker 1 4.8453
CBR1 carbonyl reductase 1 4.66685
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.6357
MYLK myosin light chain kinase 4.62395
RPP38 ribonuclease P/MRP 38kDa subunit 4.4838
SNAP25 synaptosomal-associated protein, 25kDa 3.84897
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 3.771
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.74635
PRAF2 PRA1 domain family, member 2 3.71425
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.70968
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.67345
BIRC2 baculoviral IAP repeat containing 2 3.4662
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.4031
VAT1 vesicle amine transport 1 3.3046
GATD3 glutamine amidotransferase class 1 domain containing 3 3.12213
GSTZ1 glutathione S-transferase zeta 1 3.1001
RAB21 RAB21, member RAS oncogene family 3.0664
CHN1 chimerin 1 2.91645
ARHGAP4 Rho GTPase activating protein 4 2.8877
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.84085
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.8055
MVP major vault protein 2.74265
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.71393
PLSCR3 phospholipid scramblase 3 2.706
MZT2B mitotic spindle organizing protein 2B 2.6843
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.66365
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.6285
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.46615
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.4384
MZT2A mitotic spindle organizing protein 2A 2.435
ADGRE5 adhesion G protein-coupled receptor E5 2.40545
HSPA14 heat shock 70kDa protein 14 2.3247
KCTD5 potassium channel tetramerization domain containing 5 2.29605
PCNT pericentrin 2.26885
ANXA4 annexin A4 2.25833
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.24575
IFI35 interferon-induced protein 35 2.2286
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.2266
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 2.197
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.1874
NMU neuromedin U 2.14745
CAMK1 calcium/calmodulin-dependent protein kinase I 2.1436
SMIM29 small integral membrane protein 29 2.1347
IGFLR1 IGF-like family receptor 1 2.12045
PTPRK protein tyrosine phosphatase, receptor type, K 2.1183
TESK1 testis-specific kinase 1 2.11485
ZFP36 ZFP36 ring finger protein 2.11125
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.08145
CTSL cathepsin L 2.06385
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 2.0585
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.03005
RFXANK regulatory factor X-associated ankyrin-containing protein 2.02925
NOSIP nitric oxide synthase interacting protein 2.0278
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.00885
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.0083
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.0031
MTMR14 myotubularin related protein 14 2.0016

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -5.51155
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.4865
PSRC1 proline/serine-rich coiled-coil 1 -5.4309
FASTKD5 FAST kinase domains 5 -5.34585
ARFIP2 ADP-ribosylation factor interacting protein 2 -5.34215
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.29775
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.91645
DNM1L dynamin 1-like -4.90535
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.51385
EIF5 eukaryotic translation initiation factor 5 -4.42583
ADI1 acireductone dioxygenase 1 -4.0859
GNAS GNAS complex locus -3.77767
PDHX pyruvate dehydrogenase complex, component X -3.75197
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.63002
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.37567
PCNA proliferating cell nuclear antigen -3.324
VDAC1 voltage-dependent anion channel 1 -2.93827
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.8061
GAGE1 G antigen 1 -2.73065
PHF21A PHD finger protein 21A -2.66555
PREB prolactin regulatory element binding -2.60375
APIP APAF1 interacting protein -2.59995
GPR22 G protein-coupled receptor 22 -2.58675
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -2.57755
RERGL RERG/RAS-like -2.52745
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.5248
EHF ets homologous factor -2.46205
KIAA1549L KIAA1549-like -2.4348
TRIM49D2 tripartite motif containing 49D2 -2.36235
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.3589
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 -2.34215
C1RL complement component 1, r subcomponent-like -2.342
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.33865
LRRC32 leucine rich repeat containing 32 -2.3284
STRA6 stimulated by retinoic acid 6 -2.3268
QSER1 glutamine and serine rich 1 -2.3033
CAPRIN1 cell cycle associated protein 1 -2.29548
NBPF19 neuroblastoma breakpoint family, member 19 -2.2842
ITGB1BP1 integrin beta 1 binding protein 1 -2.2714
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.2693
PUM2 pumilio RNA-binding family member 2 -2.25093
FPGT-TNNI3K FPGT-TNNI3K readthrough -2.2475
EXT2 exostosin glycosyltransferase 2 -2.23373
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -2.232
MAGEA11 melanoma antigen family A11 -2.2285
ANKRD17 ankyrin repeat domain 17 -2.22645
CDH10 cadherin 10, type 2 (T2-cadherin) -2.2231
NBPF10 neuroblastoma breakpoint family, member 10 -2.2023
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -2.2023
RAD51C RAD51 paralog C -2.1993
CCN5 cellular communication network factor 5 -2.1946
CLCN6 chloride channel, voltage-sensitive 6 -2.18595
HEATR1 HEAT repeat containing 1 -2.17685
TTBK2 tau tubulin kinase 2 -2.1634
KRT12 keratin 12, type I -2.1601
CDH9 cadherin 9, type 2 (T1-cadherin) -2.1485
ECM2 extracellular matrix protein 2, female organ and adipocyte specific -2.1453
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -2.1437
NAT10 N-acetyltransferase 10 (GCN5-related) -2.1434
SAGE1 sarcoma antigen 1 -2.12615
FRRS1L ferric-chelate reductase 1-like -2.1152
WDR19 WD repeat domain 19 -2.11235
PALMD palmdelphin -2.11075
OSBPL9 oxysterol binding protein-like 9 -2.1024
NCOA6 nuclear receptor coactivator 6 -2.0688
BCR breakpoint cluster region -2.0665
FGF7 fibroblast growth factor 7 -2.06375
TSPAN5 tetraspanin 5 -2.0625
CDH20 cadherin 20, type 2 -2.0564
TRIM44 tripartite motif containing 44 -2.05582
SMAD2 SMAD family member 2 -2.05552
FBXO3 F-box protein 3 -2.0484
RNFT2 ring finger protein, transmembrane 2 -2.03928
ZNF529 zinc finger protein 529 -2.0284
NFIB nuclear factor I/B -2.02599
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.02555
MSH4 mutS homolog 4 -2.0227
PDGFRB platelet-derived growth factor receptor, beta polypeptide -2.01655
GPR85 G protein-coupled receptor 85 -2.011
FAM53C family with sequence similarity 53, member C -2.00765
MTUS1 microtubule associated tumor suppressor 1 -2.00518
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.0051
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.00353