CRCGN011_HEPG2_24H:I11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 1.31 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN011_HEPG2_24H:I11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.0
SHB Src homology 2 domain containing adaptor protein B 4.88208
MYLK myosin light chain kinase 4.62395
PPARG peroxisome proliferator-activated receptor gamma 4.6179
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.61455
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.35595
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.1191
CDPF1 cysteine-rich, DPF motif domain containing 1 4.0531
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.03187
STIMATE STIM activating enhancer 4.01585
ATP11B ATPase, class VI, type 11B 3.9976
GPER1 G protein-coupled estrogen receptor 1 3.98193
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.87617
MAP7 microtubule-associated protein 7 3.81303
SSBP2 single-stranded DNA binding protein 2 3.71387
DYNLT3 dynein, light chain, Tctex-type 3 3.64955
SOCS2 suppressor of cytokine signaling 2 3.19837
CHMP6 charged multivesicular body protein 6 3.14415
RAI14 retinoic acid induced 14 3.102
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.0424
COQ8A coenzyme Q8A 2.9012
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.8876
CKMT1A creatine kinase, mitochondrial 1A 2.84645
FAIM Fas apoptotic inhibitory molecule 2.84145
PIH1D1 PIH1 domain containing 1 2.76655
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.73082
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.71905
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.5822
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.5666
JADE2 jade family PHD finger 2 2.53285
LOC122526780 uncharacterized LOC122526780 2.43975
GPATCH8 G patch domain containing 8 2.41478
CTBP2 C-terminal binding protein 2 2.38555
SPATA7 spermatogenesis associated 7 2.3803
RGCC regulator of cell cycle 2.2509
IMPACT impact RWD domain protein 2.2072
ECI1 enoyl-CoA delta isomerase 1 2.18045
CYCS cytochrome c, somatic 2.17155
SNCAIP synuclein, alpha interacting protein 2.15835
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 2.14815
DNASE1L1 deoxyribonuclease I-like 1 2.1415
RNF115 ring finger protein 115 2.1409
NID2 nidogen 2 (osteonidogen) 2.12895
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.1239
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.1173
NUP133 nucleoporin 133kDa 2.11145
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 2.09495
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.0832
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.0684
CCNF cyclin F 2.0615
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.0313
DEPTOR DEP domain containing MTOR-interacting protein 2.01995
UNC13A unc-13 homolog A (C. elegans) 2.0149

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -10.0
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -7.87475
ZW10 zw10 kinetochore protein -5.37615
FBXL12 F-box and leucine-rich repeat protein 12 -5.27075
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.1645
DNM1L dynamin 1-like -4.547
GRWD1 glutamate-rich WD repeat containing 1 -4.3055
FGFR4 fibroblast growth factor receptor 4 -4.14433
TCTN1 tectonic family member 1 -3.96065
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.48605
CDKN2A cyclin-dependent kinase inhibitor 2A -3.41407
GNAS GNAS complex locus -3.20991
KIF14 kinesin family member 14 -2.8753
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.8283
SLC35F2 solute carrier family 35, member F2 -2.73785
HEATR1 HEAT repeat containing 1 -2.73187
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.71292
PROS1 protein S (alpha) -2.7079
BLMH bleomycin hydrolase -2.6681
XPO6 exportin 6 -2.57748
PCM1 pericentriolar material 1 -2.57
CAB39 calcium binding protein 39 -2.56555
CA5A carbonic anhydrase VA, mitochondrial -2.48685
PNPLA3 patatin-like phospholipase domain containing 3 -2.4559
PLK1 polo-like kinase 1 -2.42485
TRIP12 thyroid hormone receptor interactor 12 -2.42145
RNF167 ring finger protein 167 -2.3802
BCHE butyrylcholinesterase -2.37335
USP6NL USP6 N-terminal like -2.34275
SHCBP1 SHC SH2-domain binding protein 1 -2.33815
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -2.33798
ERGIC2 ERGIC and golgi 2 -2.31245
LPIN2 lipin 2 -2.29653
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.2166
NEK7 NIMA-related kinase 7 -2.2064
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.19795
GAA glucosidase, alpha; acid -2.18435
ZNF586 zinc finger protein 586 -2.09815
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.0828
ITCH itchy E3 ubiquitin protein ligase -2.04397
MTTP microsomal triglyceride transfer protein -2.02565
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.00165