CRCGN011_HEPG2_24H:I12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ITE 0.65 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

109 genes differentially expressed following the CRCGN011_HEPG2_24H:I12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 10.0
SNAP25 synaptosomal-associated protein, 25kDa 8.8735
LCN2 lipocalin 2 5.6539
E2F2 E2F transcription factor 2 4.9504
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.86025
HDGFL3 HDGF like 3 4.812
MOK MOK protein kinase 4.79765
CIAO3 cytosolic iron-sulfur assembly component 3 4.71165
CSK c-src tyrosine kinase 4.66275
RPL39L ribosomal protein L39-like 4.65695
CNPY3 canopy FGF signaling regulator 3 4.453
INTS3 integrator complex subunit 3 4.32705
CXCL2 chemokine (C-X-C motif) ligand 2 4.00955
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.8941
GPER1 G protein-coupled estrogen receptor 1 3.77063
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.4464
KLHL9 kelch-like family member 9 3.1299
CBR1 carbonyl reductase 1 2.9878
SSBP2 single-stranded DNA binding protein 2 2.89087
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.88415
STMN2 stathmin 2 2.7055
MAGEH1 melanoma antigen family H1 2.69955
VGLL4 vestigial-like family member 4 2.68882
CEP15 centrosomal protein 15 2.6696
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.63085
SV2B synaptic vesicle glycoprotein 2B 2.5713
CD40 CD40 molecule, TNF receptor superfamily member 5 2.53137
SYN1 synapsin I 2.4725
SCG3 secretogranin III 2.46995
RGCC regulator of cell cycle 2.4611
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.4001
TAGLN3 transgelin 3 2.38015
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.37645
SLITRK2 SLIT and NTRK-like family, member 2 2.33425
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.3211
LGI1 leucine-rich, glioma inactivated 1 2.31715
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.30775
INA internexin neuronal intermediate filament protein, alpha 2.3038
RUNDC3A RUN domain containing 3A 2.296
AICDA activation-induced cytidine deaminase 2.2476
ADGRB3 adhesion G protein-coupled receptor B3 2.2441
MED4 mediator complex subunit 4 2.23545
VTCN1 V-set domain containing T cell activation inhibitor 1 2.23455
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.2177
KRT5 keratin 5, type II 2.21555
VSNL1 visinin-like 1 2.20257
ZNF589 zinc finger protein 589 2.19062
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.15585
SNAP91 synaptosomal-associated protein, 91kDa 2.15115
CYCS cytochrome c, somatic 2.14555
NSG2 neuronal vesicle trafficking associated 2 2.1149
WASF3 WAS protein family, member 3 2.11465
ARMCX2 armadillo repeat containing, X-linked 2 2.09695
NEFL neurofilament, light polypeptide 2.0889
CP ceruloplasmin (ferroxidase) 2.07245
ARMCX1 armadillo repeat containing, X-linked 1 2.0699
TSPYL5 TSPY-like 5 2.06575
KRT15 keratin 15, type I 2.0591
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.0528
PDE4B phosphodiesterase 4B, cAMP-specific 2.05172
CCL22 chemokine (C-C motif) ligand 22 2.0367
SYT1 synaptotagmin I 2.0335
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.02255
PCSK2 proprotein convertase subtilisin/kexin type 2 2.0223
BICDL1 BICD family like cargo adaptor 1 2.0197
CHN1 chimerin 1 2.0063
KRT14 keratin 14, type I 2.0006

decreased expression

Symbol Name Standardized Value
SCAND1 SCAN domain containing 1 -4.88955
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.82655
DNM1L dynamin 1-like -4.8234
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8192
MAP7 microtubule-associated protein 7 -4.73778
CCNB2 cyclin B2 -4.6951
CCNB1 cyclin B1 -4.6351
SLC35F2 solute carrier family 35, member F2 -4.53085
KDM3A lysine (K)-specific demethylase 3A -4.3255
FGFR4 fibroblast growth factor receptor 4 -4.2026
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.1907
GDF15 growth differentiation factor 15 -4.0414
FHL2 four and a half LIM domains 2 -3.99235
TCTN1 tectonic family member 1 -3.82555
MTFR1 mitochondrial fission regulator 1 -3.6284
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.24475
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.14725
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.93302
HLA-DMA major histocompatibility complex, class II, DM alpha -2.78845
NCOA6 nuclear receptor coactivator 6 -2.6911
CD58 CD58 molecule -2.6546
RAI14 retinoic acid induced 14 -2.6406
SNX11 sorting nexin 11 -2.61315
ACY1 aminoacylase 1 -2.59735
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.43825
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.253
AURKA aurora kinase A -2.245
RNF167 ring finger protein 167 -2.2047
TMEM94 transmembrane protein 94 -2.19775
CAB39 calcium binding protein 39 -2.19055
CEMIP2 cell migration inducing hyaluronidase 2 -2.1775
BPHL biphenyl hydrolase-like (serine hydrolase) -2.16095
SCAMP4 secretory carrier membrane protein 4 -2.1495
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.1352
ELL2 elongation factor, RNA polymerase II, 2 -2.12145
RNF123 ring finger protein 123 -2.109
NFE2L1 nuclear factor, erythroid 2-like 1 -2.09725
KLHL21 kelch-like family member 21 -2.0873
WFDC1 WAP four-disulfide core domain 1 -2.059
CYBRD1 cytochrome b reductase 1 -2.0118
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.0117
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.01125