CRCGN011_HEPG2_24H:I13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 20.38 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

328 genes differentially expressed following the CRCGN011_HEPG2_24H:I13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 8.535
COQ8A coenzyme Q8A 8.338
BTK Bruton agammaglobulinemia tyrosine kinase 7.5161
MAP7 microtubule-associated protein 7 7.4487
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 7.2805
GATA3 GATA binding protein 3 6.891
CGRRF1 cell growth regulator with ring finger domain 1 6.2932
GPATCH8 G patch domain containing 8 5.4699
CSK c-src tyrosine kinase 4.7633
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.5091
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 3.4339
RPL39L ribosomal protein L39-like 3.4289
GLB1 galactosidase, beta 1 3.3807
HSPE1 heat shock 10kDa protein 1 3.1688
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 3.1158
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 3.1051
SYNGAP1 synaptic Ras GTPase activating protein 1 3.08235
GSTO1 glutathione S-transferase omega 1 3.0469
DCTN3 dynactin 3 (p22) 3.0448
TMED3 transmembrane emp24 protein transport domain containing 3 2.9986
MFF mitochondrial fission factor 2.9896
TRAM2 translocation associated membrane protein 2 2.9671
MZT2B mitotic spindle organizing protein 2B 2.9297
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.8995
CD37 CD37 molecule 2.8797
CBR3 carbonyl reductase 3 2.8314
SF3B5 splicing factor 3b, subunit 5, 10kDa 2.8153
KRT10 keratin 10, type I 2.79333
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.7866
HMOX1 heme oxygenase 1 2.7672
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.761
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.7414
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.7036
GOLT1B golgi transport 1B 2.7003
RWDD1 RWD domain containing 1 2.6831
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.677
EVI2A ecotropic viral integration site 2A 2.6623
ZNHIT3 zinc finger, HIT-type containing 3 2.655
LYRM4 LYR motif containing 4 2.6468
CETN3 centrin, EF-hand protein, 3 2.6427
HSPA14 heat shock 70kDa protein 14 2.6411
SLN sarcolipin 2.6171
EXOC1 exocyst complex component 1 2.6124
GMFG glia maturation factor, gamma 2.6084
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.5898
UBE2D2 ubiquitin-conjugating enzyme E2D 2 2.5818
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2.5805
SNRPG small nuclear ribonucleoprotein polypeptide G 2.5728
HINT1 histidine triad nucleotide binding protein 1 2.57067
DYNLL1 dynein, light chain, LC8-type 1 2.5652
FTL ferritin, light polypeptide 2.56065
CRH corticotropin releasing hormone 2.55875
RNASE6 ribonuclease, RNase A family, k6 2.5315
ADAM9 ADAM metallopeptidase domain 9 2.5189
HOPX HOP homeobox 2.4972
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.4872
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.4871
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2.4774
PECR peroxisomal trans-2-enoyl-CoA reductase 2.4766
KRT7 keratin 7, type II 2.469
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.45485
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.4472
VAMP8 vesicle-associated membrane protein 8 2.4403
RAB5IF RAB5 interacting factor 2.4216
BGLAP bone gamma-carboxyglutamate (gla) protein 2.4067
STX1A syntaxin 1A (brain) 2.4005
MZT2A mitotic spindle organizing protein 2A 2.3839
SASH3 SAM and SH3 domain containing 3 2.3826
DUT deoxyuridine triphosphatase 2.3697
HDAC2 histone deacetylase 2 2.3668
RPS19 ribosomal protein S19 2.35915
ATP5ME ATP synthase membrane subunit e 2.3533
HPGDS hematopoietic prostaglandin D synthase 2.3422
LSP1 lymphocyte-specific protein 1 2.3417
BUD31 BUD31 homolog (S. cerevisiae) 2.3375
EIF4A2 eukaryotic translation initiation factor 4A2 2.3367
ASF1A anti-silencing function 1A histone chaperone 2.32775
MTX2 metaxin 2 2.326
HLA-DMB major histocompatibility complex, class II, DM beta 2.3249
ICAM3 intercellular adhesion molecule 3 2.3236
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.3196
SLC38A6 solute carrier family 38, member 6 2.3137
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.3101
RAB32 RAB32, member RAS oncogene family 2.3042
RPS27L ribosomal protein S27-like 2.2986
USP9Y ubiquitin specific peptidase 9, Y-linked 2.2806
CKS2 CDC28 protein kinase regulatory subunit 2 2.2788
ADRB2 adrenoceptor beta 2, surface 2.2785
CPAP centrosome assembly and centriole elongation protein 2.278
LYPLA1 lysophospholipase I 2.2761
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.2751
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.274
TMEM33 transmembrane protein 33 2.2717
CKS1B CDC28 protein kinase regulatory subunit 1B 2.2641
ADCY7 adenylate cyclase 7 2.2607
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.2529
ACYP2 acylphosphatase 2, muscle type 2.2524
MED23 mediator complex subunit 23 2.2452
DCP2 decapping mRNA 2 2.242
PFDN1 prefoldin subunit 1 2.2398
SPAG16 sperm associated antigen 16 2.2358
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.2177
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.2159
WFDC1 WAP four-disulfide core domain 1 2.2015
RAI14 retinoic acid induced 14 2.1939
NUP43 nucleoporin 43kDa 2.1929
LOC124900388 uncharacterized LOC124900388 2.1922
NOP10 NOP10 ribonucleoprotein 2.1893
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 2.1808
SNRPF small nuclear ribonucleoprotein polypeptide F 2.1799
SNX3 sorting nexin 3 2.1793
RAB33A RAB33A, member RAS oncogene family 2.1754
SH3GL1 SH3-domain GRB2-like 1 2.1722
NXT1 nuclear transport factor 2-like export factor 1 2.162
MREG melanoregulin 2.1617
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.1593
SDF2 stromal cell-derived factor 2 2.1587
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 2.1581
MAN1C1 mannosidase, alpha, class 1C, member 1 2.1535
COX7C cytochrome c oxidase subunit VIIc 2.14245
COMMD10 COMM domain containing 10 2.1395
PMF1-BGLAP PMF1-BGLAP readthrough 2.1348
CTBP2 C-terminal binding protein 2 2.132
TUBA4A tubulin, alpha 4a 2.1258
PDCD6 programmed cell death 6 2.1256
CLOCK clock circadian regulator 2.1256
CAPN1 calpain 1, (mu/I) large subunit 2.1195
DLK1 delta-like 1 homolog (Drosophila) 2.1144
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.1132
BID BH3 interacting domain death agonist 2.1115
INSM1 insulinoma-associated 1 2.1075
WDR11 WD repeat domain 11 2.1024
SFXN3 sideroflexin 3 2.10115
MPC1 mitochondrial pyruvate carrier 1 2.0998
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.0976
GPX3 glutathione peroxidase 3 2.09465
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.0932
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.0892
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.0867
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 2.0843
RBX1 ring-box 1, E3 ubiquitin protein ligase 2.08
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 2.0794
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 2.0765
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.0719
SUB1 SUB1 homolog (S. cerevisiae) 2.0669
TYROBP TYRO protein tyrosine kinase binding protein 2.0594
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.0594
CTSC cathepsin C 2.0585
ACTL6B actin-like 6B 2.0561
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.0551
RBPJ recombination signal binding protein for immunoglobulin kappa J region 2.0515
NCF4 neutrophil cytosolic factor 4, 40kDa 2.05045
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.0501
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.04005
BAD BCL2-associated agonist of cell death 2.0398
USP2 ubiquitin specific peptidase 2 2.039
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.0379
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 2.0368
GYG1 glycogenin 1 2.0362
KDM5D lysine (K)-specific demethylase 5D 2.0356
NPPA natriuretic peptide A 2.0352
DCLRE1A DNA cross-link repair 1A 2.0348
TZMP1 transition zone microprotein 1 2.02875
PPARG peroxisome proliferator-activated receptor gamma 2.0286
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 2.0273
NME5 NME/NM23 family member 5 2.0256
TBCB tubulin folding cofactor B 2.02477
MTMR14 myotubularin related protein 14 2.0206
LYRM1 LYR motif containing 1 2.0204
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2.0149
RPL27 ribosomal protein L27 2.0072
OAZ1 ornithine decarboxylase antizyme 1 2.00635
STAU2 staufen double-stranded RNA binding protein 2 2.0048
YJU2 YJU2 splicing factor homolog 2.0041
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.0025
RPL18A ribosomal protein L18a 2.0009

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
LDHD lactate dehydrogenase D -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.71
IFRD2 interferon-related developmental regulator 2 -5.97615
TBC1D31 TBC1 domain family, member 31 -4.7224
IL23A interleukin 23, alpha subunit p19 -4.0278
FCHO1 FCH domain only 1 -3.8626
TRAP1 TNF receptor-associated protein 1 -3.7669
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -3.6866
ACADVL acyl-CoA dehydrogenase, very long chain -3.6552
STAT1 signal transducer and activator of transcription 1, 91kDa -3.56168
NPDC1 neural proliferation, differentiation and control, 1 -3.5483
CDKN2A cyclin-dependent kinase inhibitor 2A -3.3183
ZNF586 zinc finger protein 586 -3.1876
ZW10 zw10 kinetochore protein -3.077
RECQL4 RecQ protein-like 4 -3.0252
BPHL biphenyl hydrolase-like (serine hydrolase) -3.0206
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.9773
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.8987
TMEM115 transmembrane protein 115 -2.8761
MCOLN3 mucolipin 3 -2.849
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -2.8451
DDR1 discoidin domain receptor tyrosine kinase 1 -2.81107
MAPKBP1 mitogen-activated protein kinase binding protein 1 -2.8087
CAPN15 calpain 15 -2.8072
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.7868
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.7459
ENPEP glutamyl aminopeptidase (aminopeptidase A) -2.74185
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.7286
DIXDC1 DIX domain containing 1 -2.6919
MSH5 mutS homolog 5 -2.6881
PCSK5 proprotein convertase subtilisin/kexin type 5 -2.68723
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.66865
MACF1 microtubule-actin crosslinking factor 1 -2.66666
ZPR1 ZPR1 zinc finger -2.6532
APEH acylaminoacyl-peptide hydrolase -2.6246
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.6191
ARCN1 archain 1 -2.6089
OSR2 odd-skipped related transciption factor 2 -2.6088
NINL ninein-like -2.5851
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.5434
BLTP3B bridge-like lipid transfer protein family member 3B -2.5343
SZT2 seizure threshold 2 homolog (mouse) -2.52305
ODR4 odr-4 GPCR localization factor homolog -2.5051
KCTD3 potassium channel tetramerization domain containing 3 -2.5016
TKFC triokinase/FMN cyclase -2.4821
GPATCH2 G patch domain containing 2 -2.475
ARID5B AT rich interactive domain 5B (MRF1-like) -2.4741
KLHL12 kelch-like family member 12 -2.4352
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.4349
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.4261
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 -2.41675
COQ6 coenzyme Q6 monooxygenase -2.4164
RNF123 ring finger protein 123 -2.4151
ECH1 enoyl CoA hydratase 1, peroxisomal -2.4023
TESK2 testis-specific kinase 2 -2.402
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.3976
MYO5C myosin VC -2.3972
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.386
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.3793
FBXL12 F-box and leucine-rich repeat protein 12 -2.3398
USP6NL USP6 N-terminal like -2.328
HCFC2 host cell factor C2 -2.3206
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -2.31823
ZNF276 zinc finger protein 276 -2.3166
MYCT1 myc target 1 -2.3163
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.315
FAN1 FANCD2/FANCI-associated nuclease 1 -2.3105
ATP4B ATPase, H+/K+ exchanging, beta polypeptide -2.3021
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.2856
AXIN1 axin 1 -2.2851
FGFBP1 fibroblast growth factor binding protein 1 -2.2807
PAAF1 proteasomal ATPase-associated factor 1 -2.2774
RAG2 recombination activating gene 2 -2.275
RBKS ribokinase -2.2749
SEMG2 semenogelin II -2.2655
YAP1 Yes-associated protein 1 -2.2549
MYRIP myosin VIIA and Rab interacting protein -2.2525
NLRX1 NLR family member X1 -2.2521
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.251
LAS1L LAS1-like (S. cerevisiae) -2.2498
SOX17 SRY (sex determining region Y)-box 17 -2.2495
SCYL3 SCY1-like 3 (S. cerevisiae) -2.2455
CNN1 calponin 1, basic, smooth muscle -2.2419
STON1 stonin 1 -2.2394
BBS7 Bardet-Biedl syndrome 7 -2.2365
TKTL1 transketolase-like 1 -2.23365
KIFC1 kinesin family member C1 -2.2321
USPL1 ubiquitin specific peptidase like 1 -2.2231
SNX17 sorting nexin 17 -2.2181
GPR161 G protein-coupled receptor 161 -2.2177
WSB1 WD repeat and SOCS box containing 1 -2.2082
AIDA axin interactor, dorsalization associated -2.2071
ACOD1 aconitate decarboxylase 1 -2.1881
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.1724
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.1597
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -2.1548
COL5A3 collagen, type V, alpha 3 -2.1482
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.1433
CXCL5 chemokine (C-X-C motif) ligand 5 -2.14035
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.1348
SMTN smoothelin -2.1338
JMJD4 jumonji domain containing 4 -2.1332
ANPEP alanyl (membrane) aminopeptidase -2.1246
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.1242
CD200 CD200 molecule -2.1215
PPT1 palmitoyl-protein thioesterase 1 -2.1158
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.1135
COL9A1 collagen, type IX, alpha 1 -2.1126
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.11
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.1068
ZNF672 zinc finger protein 672 -2.1066
NID1 nidogen 1 -2.1037
RPAP2 RNA polymerase II associated protein 2 -2.1015
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.1013
IL17B interleukin 17B -2.1013
FZD4 frizzled class receptor 4 -2.095
EDNRB endothelin receptor type B -2.0929
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like -2.0903
GPR4 G protein-coupled receptor 4 -2.08965
GREM1 gremlin 1, DAN family BMP antagonist -2.08865
PMPCA peptidase (mitochondrial processing) alpha -2.0729
MAGEA11 melanoma antigen family A11 -2.0698
MFAP5 microfibrillar associated protein 5 -2.0671
CAPN10 calpain 10 -2.0649
CHEK1 checkpoint kinase 1 -2.06135
FBXL6 F-box and leucine-rich repeat protein 6 -2.0546
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.0538
SERINC5 serine incorporator 5 -2.0493
HOXC13 homeobox C13 -2.0463
TGM4 transglutaminase 4 -2.0458
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.0435
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 -2.0417
PLXNB3 plexin B3 -2.0396
PLA2G12A phospholipase A2, group XIIA -2.037
HOXB8 homeobox B8 -2.0367
ZNF232 zinc finger protein 232 -2.033
EBLN2 endogenous Bornavirus-like nucleoprotein 2 -2.0327
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.0327
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.0307
DDB1 damage-specific DNA binding protein 1, 127kDa -2.0258
PKP1 plakophilin 1 -2.0244
IL36G interleukin 36, gamma -2.0214
DMRT1 doublesex and mab-3 related transcription factor 1 -2.0182
TMEM131L transmembrane 131 like -2.0168
MDFI MyoD family inhibitor -2.0163
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.0106
CERS6 ceramide synthase 6 -2.0099
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.0062
SV2C synaptic vesicle glycoprotein 2C -2.0037
RBM41 RNA binding motif protein 41 -2.0029