CRCGN011_HEPG2_24H:I14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 10.19 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

109 genes differentially expressed following the CRCGN011_HEPG2_24H:I14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BTK Bruton agammaglobulinemia tyrosine kinase 6.1291
UBQLN2 ubiquilin 2 5.62725
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.3521
CSK c-src tyrosine kinase 5.21075
AMDHD2 amidohydrolase domain containing 2 5.03505
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9671
CARMIL1 capping protein regulator and myosin 1 linker 1 4.9324
MYLK myosin light chain kinase 4.8487
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.7672
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.7425
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.67805
ABHD4 abhydrolase domain containing 4 4.1272
CGRRF1 cell growth regulator with ring finger domain 1 3.85905
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.72995
VGLL4 vestigial-like family member 4 3.62865
TERT telomerase reverse transcriptase 3.61225
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.60815
PRR15L proline rich 15-like 3.5398
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.51555
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.35115
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.3477
ADAT1 adenosine deaminase, tRNA-specific 1 3.2392
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.06542
CCNF cyclin F 3.01982
MEST mesoderm specific transcript 2.96355
SOCS2 suppressor of cytokine signaling 2 2.96187
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.90435
JADE2 jade family PHD finger 2 2.90002
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.87895
TREM1 triggering receptor expressed on myeloid cells 1 2.8467
SSBP2 single-stranded DNA binding protein 2 2.56562
LAMP5 lysosomal-associated membrane protein family, member 5 2.5619
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.4884
DSN1 DSN1, MIS12 kinetochore complex component 2.4526
SH3D19 SH3 domain containing 19 2.38748
CD48 CD48 molecule 2.36095
PTK2 protein tyrosine kinase 2 2.34317
TPD52L2 tumor protein D52-like 2 2.3336
GTPBP8 GTP-binding protein 8 (putative) 2.3326
ECD ecdysoneless homolog (Drosophila) 2.2547
GSTA3 glutathione S-transferase alpha 3 2.25435
SUMO4 small ubiquitin-like modifier 4 2.25375
ZNF589 zinc finger protein 589 2.23333
SREK1IP1 SREK1-interacting protein 1 2.22715
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.2265
CHEK2 checkpoint kinase 2 2.1963
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 2.1766
LYN LYN proto-oncogene, Src family tyrosine kinase 2.16798
HAND1 heart and neural crest derivatives expressed 1 2.16665
WNT6 wingless-type MMTV integration site family, member 6 2.16535
LHFPL2 lipoma HMGIC fusion partner-like 2 2.1451
CENPM centromere protein M 2.1443
DCPH1 damage control phosphatase 1 2.1394
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 2.08425
PTCH2 patched 2 2.0804
CEP57 centrosomal protein 57kDa 2.05861
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.05655
ARID3B AT rich interactive domain 3B (BRIGHT-like) 2.0419

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -7.0547
HMG20B high mobility group 20B -6.10805
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.3226
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.24975
UBE3C ubiquitin protein ligase E3C -5.249
DNM1L dynamin 1-like -5.0184
ISOC1 isochorismatase domain containing 1 -4.94995
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.8956
TRIB3 tribbles pseudokinase 3 -4.771
CDC20 cell division cycle 20 -4.66275
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.5245
MAP7 microtubule-associated protein 7 -4.19652
WASHC4 WASH complex subunit 4 -3.68772
GNAS GNAS complex locus -3.68705
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.662
PCNA proliferating cell nuclear antigen -3.5658
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.56198
TCTN1 tectonic family member 1 -3.2123
HAT1 histone acetyltransferase 1 -3.2013
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.1045
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.74169
SIM1 single-minded family bHLH transcription factor 1 -2.6598
PRPF4 pre-mRNA processing factor 4 -2.64508
WRAP73 WD repeat containing, antisense to TP73 -2.6253
SH3TC1 SH3 domain and tetratricopeptide repeats 1 -2.6137
HDAC4 histone deacetylase 4 -2.58645
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.3338
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.29875
NGRN neugrin, neurite outgrowth associated -2.28645
TRAP1 TNF receptor-associated protein 1 -2.26255
LIG4 ligase IV, DNA, ATP-dependent -2.23715
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.2161
IMMT inner membrane protein, mitochondrial -2.2075
ANGPTL8 angiopoietin like 8 -2.13815
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -2.1314
ACSL3 acyl-CoA synthetase long-chain family member 3 -2.12378
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -2.12319
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -2.11765
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.1068
MACF1 microtubule-actin crosslinking factor 1 -2.10442
CD1B CD1b molecule -2.1001
HLA-DMA major histocompatibility complex, class II, DM alpha -2.09915
TCEAL4 transcription elongation factor A (SII)-like 4 -2.05465
NLRP4 NLR family, pyrin domain containing 4 -2.03945
AZU1 azurocidin 1 -2.0211
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.01705
FASTKD5 FAST kinase domains 5 -2.01275
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.00675
GAA glucosidase, alpha; acid -2.0052
BPGM 2,3-bisphosphoglycerate mutase -2.0048