CRCGN011_HEPG2_24H:I15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 5.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

167 genes differentially expressed following the CRCGN011_HEPG2_24H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 7.3034
CYCS cytochrome c, somatic 6.2858
UBQLN2 ubiquilin 2 5.23375
SQOR sulfide quinone oxidoreductase 4.9513
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.49555
MEST mesoderm specific transcript 4.4538
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 4.40075
BTK Bruton agammaglobulinemia tyrosine kinase 3.82555
ABHD6 abhydrolase domain containing 6 3.82535
CDPF1 cysteine-rich, DPF motif domain containing 1 3.8161
SHB Src homology 2 domain containing adaptor protein B 3.6734
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.5117
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.40185
FZD1 frizzled class receptor 1 3.30785
NOSIP nitric oxide synthase interacting protein 3.2176
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 3.20905
DMAP1 DNA methyltransferase 1 associated protein 1 3.1844
EVI2A ecotropic viral integration site 2A 3.09005
TRIM13 tripartite motif containing 13 3.05365
DIPK1A divergent protein kinase domain 1A 2.82083
SKIC8 SKI8 subunit of superkiller complex 2.77312
CD180 CD180 molecule 2.7731
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.70907
EDN1 endothelin 1 2.7007
EXOC1 exocyst complex component 1 2.6611
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.64175
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.61378
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 2.6131
CYTIP cytohesin 1 interacting protein 2.5721
H2BC12 H2B clustered histone 12 2.55078
COPS4 COP9 signalosome subunit 4 2.50825
RAI14 retinoic acid induced 14 2.4925
CHN1 chimerin 1 2.48385
SATB1 SATB homeobox 1 2.4685
ZNF318 zinc finger protein 318 2.46685
RAB33A RAB33A, member RAS oncogene family 2.45835
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.4096
MTRF1 mitochondrial translational release factor 1 2.37965
TREM2 triggering receptor expressed on myeloid cells 2 2.3751
HEBP1 heme binding protein 1 2.35595
FSHB follicle stimulating hormone, beta polypeptide 2.303
SH3YL1 SH3 and SYLF domain containing 1 2.2913
CCL2 chemokine (C-C motif) ligand 2 2.27635
BDKRB1 bradykinin receptor B1 2.2557
COL11A1 collagen, type XI, alpha 1 2.25402
MRPL34 mitochondrial ribosomal protein L34 2.24885
TFEC transcription factor EC 2.24585
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.23835
CLN3 ceroid-lipofuscinosis, neuronal 3 2.2376
RFTN1 raftlin, lipid raft linker 1 2.2326
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 2.2229
CUX2 cut-like homeobox 2 2.21865
DOC2A double C2-like domains, alpha 2.1968
CBR3 carbonyl reductase 3 2.18715
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 2.18295
GPATCH8 G patch domain containing 8 2.14328
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.14037
JADE2 jade family PHD finger 2 2.13828
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 2.1187
IRF8 interferon regulatory factor 8 2.10875
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 2.1046
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.10455
LYSET lysosomal enzyme trafficking factor 2.0981
KATNBL1 katanin p80 subunit B-like 1 2.0907
PGK1 phosphoglycerate kinase 1 2.08502
EVI2B ecotropic viral integration site 2B 2.07685
COPS7A COP9 signalosome subunit 7A 2.0672
CIAO3 cytosolic iron-sulfur assembly component 3 2.0624
LRRK1 leucine-rich repeat kinase 1 2.05125
RHOG ras homolog family member G 2.0262
MAPK7 mitogen-activated protein kinase 7 2.0117
KCTD13 potassium channel tetramerization domain containing 13 2.00915
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.00485
GAS6 growth arrest-specific 6 2.00388
PRDX4 peroxiredoxin 4 2.0019
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.00065

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -9.12485
CHMP4B charged multivesicular body protein 4B -9.10995
GNAS GNAS complex locus -7.13724
GDF15 growth differentiation factor 15 -7.10105
TM9SF3 transmembrane 9 superfamily member 3 -5.70415
TSPAN4 tetraspanin 4 -5.1923
ZW10 zw10 kinetochore protein -5.1068
CD320 CD320 molecule -5.0381
PCNA proliferating cell nuclear antigen -5.0
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.96235
TUBB6 tubulin, beta 6 class V -4.51275
TLCD3A TLC domain containing 3A -4.283
TRIB3 tribbles pseudokinase 3 -4.23255
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -4.1225
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.03205
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.733
ACAA1 acetyl-CoA acyltransferase 1 -3.2248
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.17585
CLTC clathrin, heavy chain (Hc) -3.0444
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.84165
ZMIZ1 zinc finger, MIZ-type containing 1 -2.82805
SYNM synemin, intermediate filament protein -2.7521
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -2.75165
RBM15B RNA binding motif protein 15B -2.72115
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.69145
AARS1 alanyl-tRNA synthetase 1 -2.69115
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.68255
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.6143
RLIM ring finger protein, LIM domain interacting -2.5774
KCTD14 potassium channel tetramerization domain containing 14 -2.56728
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -2.5335
REEP5 receptor accessory protein 5 -2.48225
NRSN2 neurensin 2 -2.4789
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.4282
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.42375
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.39975
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -2.389
SSUH2 ssu-2 homolog (C. elegans) -2.37475
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.3534
TUBB2B tubulin, beta 2B class IIb -2.3353
MIA melanoma inhibitory activity -2.32505
SOX12 SRY (sex determining region Y)-box 12 -2.31665
HELZ helicase with zinc finger -2.304
DSG2 desmoglein 2 -2.2937
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.27435
MACROH2A2 macroH2A.2 histone -2.2678
PROS1 protein S (alpha) -2.23685
GTF2IRD1 GTF2I repeat domain containing 1 -2.23465
MXRA7 matrix-remodelling associated 7 -2.2338
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.23038
TAC1 tachykinin, precursor 1 -2.23
SCTR secretin receptor -2.2204
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.22005
CD151 CD151 molecule (Raph blood group) -2.2187
HOXC11 homeobox C11 -2.21315
ATG9A autophagy related 9A -2.20855
HOXC13 homeobox C13 -2.2024
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.1953
MAPK13 mitogen-activated protein kinase 13 -2.1908
ANGPTL7 angiopoietin-like 7 -2.18905
HOXC10 homeobox C10 -2.18865
NTM neurotrimin -2.1793
ADAMTSL3 ADAMTS-like 3 -2.1679
SAFB scaffold attachment factor B -2.15782
KIF11 kinesin family member 11 -2.1556
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -2.1356
COL9A3 collagen, type IX, alpha 3 -2.12455
BPHL biphenyl hydrolase-like (serine hydrolase) -2.11365
KDM3B lysine (K)-specific demethylase 3B -2.11172
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.10683
HDAC1 histone deacetylase 1 -2.1049
SLC35F2 solute carrier family 35, member F2 -2.1034
FOS FBJ murine osteosarcoma viral oncogene homolog -2.10085
SV2C synaptic vesicle glycoprotein 2C -2.0897
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.06835
FKBP10 FK506 binding protein 10, 65 kDa -2.065
GAA glucosidase, alpha; acid -2.0602
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -2.04865
DDRGK1 DDRGK domain containing 1 -2.04595
PHKB phosphorylase kinase, beta -2.04072
PPP1R9A protein phosphatase 1, regulatory subunit 9A -2.0391
COCH cochlin -2.0375
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.0351
WDR7 WD repeat domain 7 -2.03485
EPHA2 EPH receptor A2 -2.02385
NLRP4 NLR family, pyrin domain containing 4 -2.0228
ARHGAP19 Rho GTPase activating protein 19 -2.01265
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.0096
TDG thymine-DNA glycosylase -2.0059
CBFB core-binding factor, beta subunit -2.00262
OXA1L oxidase (cytochrome c) assembly 1-like -2.00125