CRCGN011_HEPG2_24H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 2.55 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN011_HEPG2_24H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.57955
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.41195
GPATCH8 G patch domain containing 8 5.27058
CXCL2 chemokine (C-X-C motif) ligand 2 5.09515
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.96905
TLR4 toll-like receptor 4 4.5704
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.40205
STK10 serine/threonine kinase 10 4.31815
PPARG peroxisome proliferator-activated receptor gamma 4.0439
CCDC85B coiled-coil domain containing 85B 3.8972
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.71185
IDE insulin-degrading enzyme 3.62613
EPHB2 EPH receptor B2 3.48793
MEST mesoderm specific transcript 3.46355
FAIM Fas apoptotic inhibitory molecule 3.3714
KLHL9 kelch-like family member 9 3.08322
CHN1 chimerin 1 2.9299
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.9108
SSBP2 single-stranded DNA binding protein 2 2.74587
RAI14 retinoic acid induced 14 2.66045
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.4505
JADE2 jade family PHD finger 2 2.43267
HIKESHI heat shock protein nuclear import factor hikeshi 2.4154
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.33707
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.32275
EXOSC8 exosome component 8 2.2201
TBXA2R thromboxane A2 receptor 2.17346
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.11595
DYNLT3 dynein, light chain, Tctex-type 3 2.1041
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.04033
KANK1 KN motif and ankyrin repeat domains 1 2.03115
SH3GL2 SH3-domain GRB2-like 2 2.02535
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 2.02338
FANCF Fanconi anemia, complementation group F 2.02105
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.0183
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2.00105

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -5.34335
FBXL12 F-box and leucine-rich repeat protein 12 -5.0666
PCNA proliferating cell nuclear antigen -4.9283
LDHD lactate dehydrogenase D -4.82815
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8192
ANKRD10 ankyrin repeat domain 10 -4.64055
FGFR4 fibroblast growth factor receptor 4 -4.59473
MRPS2 mitochondrial ribosomal protein S2 -4.05495
ARID5B AT rich interactive domain 5B (MRF1-like) -3.71885
GNAS GNAS complex locus -3.54101
UBE3C ubiquitin protein ligase E3C -3.35165
CCNB2 cyclin B2 -3.22675
RNF167 ring finger protein 167 -2.92255
PROS1 protein S (alpha) -2.76375
OXA1L oxidase (cytochrome c) assembly 1-like -2.75465
HEATR1 HEAT repeat containing 1 -2.73475
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.6388
NUDCD3 NudC domain containing 3 -2.422
NRIP1 nuclear receptor interacting protein 1 -2.40167
CAB39 calcium binding protein 39 -2.1904
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.15695
ROM1 retinal outer segment membrane protein 1 -2.12845
BLMH bleomycin hydrolase -2.10215
HLA-DMA major histocompatibility complex, class II, DM alpha -2.08815
CDK6 cyclin-dependent kinase 6 -2.0133