| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4,8-dihydroxy-2-quinolinecarboxylic acid 1.27 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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70 genes differentially expressed following the CRCGN011_HEPG2_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TAC4 | tachykinin 4 (hemokinin) | 5.56945 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 5.35145 |
| UBQLN2 | ubiquilin 2 | 5.3091 |
| MOK | MOK protein kinase | 5.1511 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.8687 |
| PNKP | polynucleotide kinase 3'-phosphatase | 4.86695 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 4.768 |
| ADRB2 | adrenoceptor beta 2, surface | 4.66275 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 4.51055 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.50725 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.86212 |
| MICALL1 | MICAL-like 1 | 3.84538 |
| MEST | mesoderm specific transcript | 3.4345 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 3.3746 |
| TLR4 | toll-like receptor 4 | 3.25665 |
| GPATCH8 | G patch domain containing 8 | 2.9713 |
| MELK | maternal embryonic leucine zipper kinase | 2.96865 |
| PIH1D1 | PIH1 domain containing 1 | 2.88685 |
| PLSCR3 | phospholipid scramblase 3 | 2.82372 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 2.72255 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.42185 |
| METRN | meteorin, glial cell differentiation regulator | 2.3918 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 2.3273 |
| SELENOW | selenoprotein W | 2.29955 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 2.27975 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.15975 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 2.15435 |
| PLXNB2 | plexin B2 | 2.1535 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.13018 |
| CIDEB | cell death-inducing DFFA-like effector b | 2.1236 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.10865 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 2.1012 |
| KLHL9 | kelch-like family member 9 | 2.08687 |
| TRIM6-TRIM34 | TRIM6-TRIM34 readthrough | 2.055 |
| XAF1 | XIAP associated factor 1 | 2.0178 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.01635 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -7.8814 |
| UGDH | UDP-glucose 6-dehydrogenase | -5.067 |
| GDF15 | growth differentiation factor 15 | -5.0 |
| LDHD | lactate dehydrogenase D | -4.80655 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.6559 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.3377 |
| SLC35F2 | solute carrier family 35, member F2 | -4.3348 |
| MAP7 | microtubule-associated protein 7 | -4.02897 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.4708 |
| GNAS | GNAS complex locus | -3.44875 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -3.24005 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -3.23515 |
| VDAC1 | voltage-dependent anion channel 1 | -2.74472 |
| RBM15B | RNA binding motif protein 15B | -2.5082 |
| RGS2 | regulator of G-protein signaling 2 | -2.50355 |
| DDX43 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 | -2.47305 |
| PRPF4 | pre-mRNA processing factor 4 | -2.43523 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.41515 |
| USP22 | ubiquitin specific peptidase 22 | -2.39095 |
| LGMN | legumain | -2.35095 |
| RNF167 | ring finger protein 167 | -2.29355 |
| KIAA0232 | KIAA0232 | -2.2839 |
| FAM168B | family with sequence similarity 168, member B | -2.26265 |
| APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 | -2.2393 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.19502 |
| ZNF84 | zinc finger protein 84 | -2.19435 |
| SESN1 | sestrin 1 | -2.1699 |
| RPH3A | rabphilin 3A | -2.13535 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | -2.0892 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.0635 |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) | -2.05935 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | -2.05405 |
| TCEA2 | transcription elongation factor A (SII), 2 | -2.0444 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.0323 |
